40% madzi sungunuka azelaic asidi

Malinga ndi gulu la mankhwala a FDA, asidi azelaic ndi wa gulu B mankhwala, amene angagwiritsidwe ntchito mosamala pa mimba ndi mkaka wa m`mawere.It akhoza kuletsa kupanga ndi zochita za zotakasika za okosijeni mitundu, amene n`kopindulitsa kwa odana ndi kutupa ndi achire zosiyanasiyana. zotsatira za mankhwala. Pochepetsa kaphatikizidwe ka filamentous keratin, imatha kuchepetsa kwambiri keratinization ya zipolopolo za tsitsi ndipo imakhala yabwino pakhungu.
Ikhoza kulimbikitsa kuyamwa kwa mankhwalawa pakhungu powonjezera asidi azelaic ku zodzoladzola zonona. Kuonjezera apo, asidi azelaic amatha kulepheretsa mabakiteriya ndikuwongolera katulutsidwe ka sebum, koma kugwirizana kwake kumakhala kochepa kwambiri chifukwa cha zolakwika zake ziwiri zachilengedwe za kusungunuka kwamadzi komanso kusungunuka kwakukulu. Zaka 5 mu sebaceous gland- α Ntchito ya reductase imasinthidwa kukhala dihydrotestosterone, yomwe imatsogolera ku hyperfunction ya sebaceous gland, zomwe zimapangitsa kuti mafuta asungunuke kwambiri. Azelaic acid imatha kuletsa mopikisana 5- α Ntchito ya reductase imalepheretsa kutembenuka kwa androjeni wambiri kukhala dihydrotestosterone, ndipo pamapeto pake imalepheretsa kutulutsa kwakukulu kwamafuta acids aulere m'matumbo a sebaceous.
Itha kulepheretsa kupanga ma reactive oxygen free radicals ndikuchita gawo loletsa kutupa. Hydroxylation ya mankhwala onunkhira omwe amapangidwa ndi magulu a okosijeni ogwira ntchito komanso peroxidation ya arachidonic acid inaletsedwa mu vitro.
40% ya azelaic acid yosungunuka m'madzi yopangidwa ndi Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. Pa kutentha kwa chipinda, amaikidwa m'madzi kuti agwedezeke ndi kusungunuka, ndipo njira yamadzimadzi imakhala yomveka komanso yowonekera.
Kuchulukirachulukira kwa ma sebaceous ducts m'mitsempha ya tsitsi kumatsekereza ma follicles atsitsi, pomwe asidi azelaic imakhala ndi anti keratotic pakhungu labwinobwino komanso khungu lomwe lili ndi ziphuphu, zomwe zimatha kuchepetsa kaphatikizidwe ka filamentous keratin ndikuletsa keratosis yochulukirapo ya ma follicle atsitsi.