10 Ubwino Wodabwitsa Waumoyo wa Akuamma

Akuamma, yemwe amadziwikanso kuti Picralima Nitida, amachokera ku chitsamba chonga mtengo (chofanana ndi kutalika kwa zomera za Kratom) chomwe chimamera m'mphepete mwa mitsinje ku West Africa. Ma alkaloid akuluakulu omwe amapezeka mumbewu za Akuamma ndi Akuammine ndi Pericine - omwe onse amafanana ndi Mitragynine ku Kratom.

Chifukwa Akuamma amafanana m'njira zambiri - zotsatira za kutenga Akuamma Seed ndizofanana kwambiri ndi kuwononga masamba a Kratom.

The alkaloids waukulu kupanga chomera kwambiri amphamvu ndi ogwira monga;

• Akuammidine- iyi ndiye alkaloid yayikulu ya mbewuyi ndipo imagwira ntchito pokopa malo omangira opioid. The alkaloid amapereka makhalidwe analgesic kuthandiza kuthetsa ululu komanso kutumikira monga omasuka minofu.
• Akuammine- alkaloid iyi ili ndi kuyanjana kwakukulu kwa malo omangira mu-opioid, mosiyana ndi Akuammidine. Zimathandizira popereka zotsatira za analgesic, komabe, zitha kupangitsa kuti matumbo asamayende bwino ngati agwiritsidwa ntchito pamlingo wapamwamba.
• Akuammicine- alkaloid iyi, kumbali ina, ili ndi kuyanjana kwakukulu kwa malo omangira kappa-opioid.
• Pseudo-Akuammigine- alkaloid iyi imapereka zonse zotsutsana ndi zotupa komanso zochepetsa ululu. Kutengera ndi mlingo, alkaloid imasangalatsa, imathandizira kugundana kwa minofu ya chigoba, kukanika kwa minofu yosalala, dongosolo lapakati lamanjenje, komanso kupuma.
• Akuammigine- uyu adangowonetsa kuti ali ndi anti-adrenergic pamitsempha yamagazi komanso mtima.
• Pericine- iyi yasonyezedwa kuti imamangiriza ku ma-opioid receptors, komabe, ikhoza kuyambitsa kugwedezeka komwe kumabweretsa kugundana kwa minofu mosasamala.

Masiku ano Akuamma amaonedwa ngati njira yabwinoko kuposa zinthu zina zowawa chifukwa amatsimikizira kuti ululu wonse umakhalapo. Izi zapangitsanso kafukufuku wambiri wachipatala pa chomeracho kuti amvetsetse kukhulupirika kwa mtengo wake wamankhwala bwino. Pakati pazabwino zambiri zathanzi za akuamma zikuphatikizapo;

1) Ntchito Yothana ndi Malungo

Alkaloid yogwira, Akuammine ndiyomwe imayambitsa matenda a malungo. Izi zimapangitsa akuamma kukhala imodzi mwa zitsamba zolimbana ndi malungo zomwe zimagwiritsidwa ntchito padziko lonse lapansi. Zomwe zimatengedwa kuchokera ku njere za akuamma, makungwa a tsinde, ndi rind za zipatso zasonyezedwa kuti zili ndi ntchito yolepheretsa kumenyana ndi Plasmodium falciparum yosamva mankhwala motero kuchirikiza mfundo yakuti therere ndi mankhwala oletsa malungo.

2) Ntchito ya Trypanocidal

Mbewu za Akuamma zimadziwika kuti zimakhala ndi anti-parasitic effect pa tizilombo toyambitsa matenda makamaka Trypanosoma, yomwe ndi parasitic protozoan yomwe imayambitsa matenda osiyanasiyana monga matenda ogona pakati pa ena. Kafukufuku wasayansi watsimikiziranso zotsatira za trypanocidal za mbewu za akuamma.

3) Anti-Leishmanial Activity

Picralima Nitida ndi imodzi mwazomera zomwe zotulutsa zake zidawunikidwa kuti zithetse vuto la leishmanial pogwiritsa ntchito makina opangidwa ndi radiorespirametric microtechnique ndipo zotsatira zake zidatsimikizira zochita motsutsana ndi Leishmania donovani pa 50 kapena kuchepera ma micrograms/ml.

4) Ntchito ya Antipyretic

Malinga ndi kafukufuku woyambirira wamankhwala opangidwa ndi methanolic wa akuamma, zotsatira zake zidawonetsa ntchito yamphamvu komanso yodalira mlingo ya antipyretic yokhala ndi antipyrexia yapamwamba (38.7%) poyerekeza ndi ya aspirin (29.0%). Mtengo wamankhwala uwu wa therere umalungamitsa chifukwa chake udakali wofala m’maiko ambiri ku W. Africa.

5) Ntchito ya Analgesic

Ma alkaloid otengedwa ku akuamma awonetsedwa kuti ali ndi opioid analgesic activation. Popita nthawi, anthu ayamba kugwiritsa ntchito mbewu ya akuamma kuti athetse ululu womwe umabwera chifukwa cha migraines, fibromyalgia, ndi nyamakazi pakati pa ena bwino.

Imawonedwanso ngati njira yabwinoko yopangira ma opiates omwe amabwera ndi zotsatirapo zosiya komanso kuzolowera. Mbeu zochokera ku chomera ichi ndi zachibadwa ndipo zimakhala ndi zotsatira zochepa. Mukhozanso kutenga mbewu za zilonda zam'mimba kuti muchepetse ululu pambuyo pa mphindi 15-30.

6) Ntchito Yotsutsa Kutupa

Ma alkaloid akupanga kuchokera ku akuamma adafufuzidwa chifukwa cha zotsutsana ndi zotupa ndipo zotsatira zake zidawonetsa kuti pseudo-Akuammigine idachepetsa kwambiri kuchuluka kwapakatikati komanso kutupa kwathunthu pambuyo pakamwa pakamwa kwa alkaloid.

7) Ntchito Yoletsa Kutsekula M'mimba

Chomera cha Akuamma chakhala chikugwiritsidwa ntchito kwambiri m'maiko a W. Africa kuchiza matenda ambiri kuphatikizapo kamwazi pakati pa matenda ena am'mimba.

Malinga ndi kafukufuku wofuna kudziwa zochita za anti-shigellosis za kutulutsa kwa methanol kwa akuamma pa Shigella dysenteriae mtundu 1 wotsekula m'mimba mwa makoswe, zidawoneka kuti zomwe zatulutsidwazo zinali ndi antimicrobial zotsatira pa khumi ndi limodzi mwa mitundu 17 yoyesedwa.

Chotsitsacho chinachepetsa kwambiri kuchuluka kwa ndowe zomwe zimatulutsidwa. Kuchokera pazopezazi, zikuwonekeratu kuti zotulutsa za Picralima Nitida ndizothandiza kwambiri pochotsa matenda am'mimba monga kutsekula m'mimba.

8) Antioxidant ndi Anti-Diabetic Activities

Matenda a shuga mellitus ndi vuto la metabolic lomwe nthawi zambiri limalumikizidwa ndi kupsinjika kwa okosijeni ndipo limadziwika ndi hyperglycemia yosatha.

Malinga ndi kafukufuku wazachipatala wofufuza mphamvu ya antioxidant ndi anti-diabetes ya zotulutsa za methanol zamasamba ndi mapesi a chomera cha akuamma, zidawoneka kuti tsamba la methanol la zitsamba likuwonetsa zochitika za hypoglycemia ndi pafupifupi 38% ya kuchepetsa glycemia chifukwa cha alkaloid. -akuammicine, yomwe imakhulupirira kuti imalimbikitsa kuyamwa kwa glucose m'maselo, motero kuchepetsa mlingo wa shuga m'magazi.

Kuchokera pazopeza izi, zikuwonekeratu kuti chomera cha akuamma chili ndi antioxidant komanso anti-diabetesic properties motero chingagwiritsidwe ntchito pochiza matenda a shuga komanso kukhala maziko omwe mankhwala atsopano ndi amphamvu angapangidwe kuti athandize kuchiza matenda a shuga. ndi zina zokhudzana ndi thanzi.

9) Zochita Zolimbitsa Thupi

Zotulutsa zambewu za thererezi zimadziwika kuti zimachepetsa kupsinjika ndi nkhawa kuti munthu akhale wodekha, wodekha, komanso wopumula. Zasonyezedwanso kuti zimathandizira kuthana ndi mantha pomwe zimaganiziridwanso ngati zolimbitsa thupi ndi anthu omwe amakumana ndi vuto la kugona monga kusowa tulo komanso maloto owopsa.

Mbeuzo zimakhala ndi mphamvu zoziziritsa kukhosi motero zimapatsa munthu tulo tamtendere ngati atamwa nthawi yogona. Zimanenedwanso kuti kukhazika mtima pansi kwa therere kudzachitikira pafupifupi nthawi yomweyo kukulolani kuti muzisangalala ndi mpumulo wabwino wopanda ululu, nkhawa kapena nkhawa.

10) Ntchito Yotsutsa Chilonda

Kafukufuku wowunika ntchito yolimbana ndi zilonda zam'mimba ya methanol, tizigawo ta methanol ndi chloroform ya mbewu za akuamma adawonetsa kuti tizigawo tating'onoting'ono ta zitsamba timatulutsa kuchepa kwakukulu kwa index ya zilonda komanso kuchuluka kwa acidity ndi pepsin.

M'malo mwake, kuwonjezeka kwa Mucoprotective parameter kunakhazikitsidwa. Katundu woletsa zilonda za chomera ichi amawonjezera phindu la thanzi lomwe mbewuyo imadziwika nayo.