N-acetylneuraminic acid , yomwe imadziwikanso kuti sialic acid, ndi molekyulu yopezeka mwachilengedwe yomwe imapezeka m'machitidwe osiyanasiyana achilengedwe. Imagwira ntchito zofunika kwambiri pama foni am'manja ndipo imakhala ndi ntchito zingapo m'magawo osiyanasiyana.
Sialic acid ndi asidi wa kaboni wa kaboni naini ndipo amachokera ku neuraminic acid. Nthawi zambiri amapezeka kumapeto kwenikweni kwa ma glycans (oligosaccharide chain) omwe amamangiriridwa ku mapuloteni kapena lipids pama cell. Ma glycans awa, omwe amadziwikanso kuti sialylated glycans, amagwira nawo ntchito zofunika kwambiri zama cell monga kuzindikira kwa ma cell, kuwonetsa, komanso kuyankha kwa chitetezo chamthupi.
Kodi Ntchito ZaN-acetylneuraminic Acid?
- Kuzindikirika kwa Mafoni: Sialic acid yokhala ndi ma glycans amakhala ngati zolembera zozindikirika pama cell. Amagwira nawo ntchito zosiyanasiyana monga kumatira kwa ma cell, kuzindikira kwa maselo a chitetezo chamthupi, komanso kusiyanitsa.
- Mayankho a Immune: Sialic acid imagwira ntchito yofunika kwambiri pakuwongolera chitetezo chamthupi. Itha kukhala ngati cholandilira tizilombo toyambitsa matenda, kuthandizira kuyambitsa chitetezo chamthupi polimbana ndi tizilombo toyambitsa matenda. Kuphatikiza apo, kusintha kwa sialic acid pa ma antibodies kumathandizira magwiridwe antchito awo chitetezo chamthupi.
- Ma Signal:Sialic acid imatha kutenga nawo gawo munjira zowonetsera ma cell ndikuwongolera njira zofunika zama cell monga kuchuluka kwa ma cell, kusiyanitsa, ndi apoptosis.
- Chitetezo ndi Mafuta: Sialic acid imateteza maselo ku zinthu zovulaza pochita ngati chotchinga chakuthupi. Zimathandiziranso kudzoza kwa mucous membranes, monga zomwe zili m'mapapo ndi m'mimba.
Kodi Mapulogalamu aN-acetylneuraminic Acid?
- Makampani Azamankhwala: Sialic acid-based compounds ali ndi mphamvu zopangira mankhwala. Mwachitsanzo, zotumphukira za sialic acid zafufuzidwa chifukwa cha mphamvu zawo zoletsa ma virus komanso ngati zoletsa ma virus. Kuphatikiza apo, ma sialidase inhibitors, omwe amalepheretsa kuchotsedwa kwa zotsalira za sialic acid ku glycans, akufufuzidwa kuti agwiritse ntchito pochiza.
- Kafukufuku wa Glycobiology: Sialic acid ndi sialylated glycans amaphunziridwa kwambiri mu gawo la glycobiology. Kusanthula kwawo kumatha kupereka zidziwitso zamatenda, magwiridwe antchito a cell, komanso kupezeka kwa biomarker.
- Zida Zowunikira: Sialic acid milingo, zosintha, ndi zosintha zimagwiritsidwa ntchito ngati zolembera m'matenda osiyanasiyana monga khansa, matenda amtima, komanso kusokonezeka kwa majini. Kuzindikira ndi kusanthula kwa sialic acid kungapereke chidziwitso chofunikira cha matenda.
- Makampani a Chakudya ndi Chakudya: Sialic acid imapezeka muzakudya zina, monga mkaka ndi mazira. Nthawi zina amawonjezeredwa ku mankhwala a makanda monga chowonjezera chopatsa thanzi kwa makanda omwe sakuyamwitsa.
Kulemba nkhani: Coco Zhang
Nthawi yotumiza: Jan-12-2024
