Noopept: Zonse Zomwe Muyenera Kudziwa

Imawonjezera Ntchito Yachidziwitso

Umboni wochuluka wachipatala umathandizira ubwino wa Noopept pazinthu zosiyanasiyana zamaganizo monga kukumbukira, kuphunzira, ndi kulingalira:

• Odwala omwe ali ndi vuto lachidziwitso chifukwa cha kupwetekedwa mtima kapena matenda a ubongo, Noopept inapititsa patsogolo ntchito ya ubongo monga umboni wa kuwonjezeka kwa alpha- ndi beta-rhythms mphamvu mu electroencephalogram (EEG).
• Kulamulira kwa Noopept pa mlingo wa 20 mg tsiku lililonse kwa miyezi ya 2 kumapangitsa kuti chidziwitso chikhale bwino kwa odwala omwe ali ndi sitiroko ndipo ali ndi chitetezo chokwanira.
• M'zinyama zingapo za matenda a Alzheimer's (AD), Noopept adateteza maselo a ubongo wa makoswe ku amyloid beta toxicity (causative agent ya AD) poletsa kuwonongeka kwa okosijeni, kuteteza calcium kuchulukira, komanso kupondereza apoptosis (pulogalamu ya cell kufa).
• Kubwereza mobwerezabwereza kwa Noopept mu makoswe kumaphunzira bwino poyerekeza ndi mlingo umodzi.
• Muchitsanzo cha makoswe a sitiroko, Noopept adawonetsa zonse zobwezeretsa kuzindikira komanso neuroprotective katundu.
• Munthawi yabwino komanso ya Down's syndrome muubongo wamunthu, Noopept idalepheretsa kuwonongeka kwa okosijeni ndi apoptosis.
• Mu makoswe ozindikira, ulamuliro wa Noopept unawonjezera ntchito za ubongo mu EEG.
• Noopept ili ndi mphamvu yowonjezera miyeso ya Nerve Growth Factor ndi Brain Derived Neurotrophic Factor, yomwe imagwirizanitsidwa ndi kusintha kosatha kukumbukira.
• Noopept ikhoza kuthandizira kupititsa patsogolo chidziwitso mwa kupititsa patsogolo zizindikiro zamagetsi pakati pa neurons.
• Noopept pa chiŵerengero cha 1: 1 kapena kuwirikiza kakhumi kwakukulu kunawoneka kuchepetsa kwambiri matupi a Lewy (mapuloteni omwe amachititsa matenda a Parkinson) mu ubongo.
• Mu mbewa zomwe zili ndi vuto losokoneza bongo, kulamulira kosalekeza kwa Noopept kunawonjezera mphamvu ya anticonvulsant mankhwala valproate.
• Kafukufuku wina adanena kuti Noopept imakhala ndi zotsatira zake za neuroprotective kudzera mu antioxidant ndi anti-inflammatory properties.
• Mu makoswe, Noopept inalimbikitsa kufalitsa kwa mitsempha mu ubongo.
• Mu mbewa, Noopept analepheretsa kwathunthu chitukuko cha matenda a chidziwitso opangidwa ndi scopolamine.
• Mu makoswe, Noopept inasintha kuwonongeka kwa chidziwitso mwa kuonjezera milingo ya ubongo-derived neurotrophic factor (BDNF).
• Mu chitsanzo cha mbewa cha matenda a Alzheimer's, Noopept analepheretsa kukumbukira kukumbukira.
• Kafukufuku wasonyeza kuti Noopept ingathandize kupewa matenda a Alzheimers mwa kulepheretsa mapangidwe a mapuloteni osadziwika bwino mu ubongo ndi kuchepetsa ntchito ya kupsinjika maganizo-activated mitogen-activated protein kinases (MAPK).
• Mu mbewa, jekeseni wa Noopept 5 mphindi musanaphunzire bwino kukumbukira kwanthawi yayitali.
• Mu makoswe okhala ndi sitiroko, chithandizo cha Noopept chinachepetsa gawo la infarction (minofu yakufa) mu ubongo.
• Mu makoswe, kayendetsedwe ka Noopept pa 5 mg / kg kudzera m'majekeseni opangidwa ndi chidziwitso chowonjezera zotsatira.
• Ulamuliro wa 0.5-10 mg / kg wa Noopept mu makoswe unalimbikitsa kuphunzira kwa gawo limodzi pambuyo pa kayendetsedwe kamodzi, pamene kulamulira mobwerezabwereza kunawonjezera luso la kuphunzira kwa makoswe omwe analephera maphunziro oyambirira mu ntchito yopewa kupeŵa (chiyeso chomwe chimayesa kuphunzira ndi kukumbukira) .
• Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) ulamuliro pa mlingo wa 0.5 mg / kg 15 maminiti asanayambe maze a Morris adayambitsa kusintha kwakukulu kwa kukumbukira kwa nthawi yaitali.
• Mu makoswe omwe ali ndi cerebral-induced cerebral ischemia, kayendetsedwe ka Noopept kudzera m'majakisoni ndi njira yapakamwa kumapangitsanso kubweza mayankho opewa.
• Kafukufuku wama cell adapeza kuti Noopept idalepheretsa neurodegeneration yoyambitsidwa ndi glutamate ndi kupsinjika kwa okosijeni.
• Mu makoswe omwe anali ndi vuto lachidziwitso chifukwa cha lobectomy, njira yomwe imaphatikizapo kuchotsedwa kwa lobe yonse ya ubongo, Noopept inalimbikitsa kubwezeretsedwa kwa kuphunzira ndi kukumbukira.
• Kafukufuku wama cell adanenanso kuti Noopept idakulitsa kufalikira kwa ma sign pakati pa maselo aubongo.

Amalimbana ndi Nkhawa

• Luso lokulitsa chidziwitso la Noopept limatulutsanso zotsutsana ndi nkhawa malinga ndi maphunziro:
• Kulamulira kwa Noopept kwa odwala omwe ali ndi vuto lochepa lachidziwitso kumachepetsa kutopa, nkhawa, ndi kukwiya.
• Odwala omwe ali ndi chifuwa chachikulu cha chifuwa chachikulu, chithandizo cha Noopept chinachepetsa mawonetseredwe a nkhawa.
• Mu makoswe, utsogoleri wa Noopept unagwirizanitsidwa ndi kuwonjezeka kwa ntchito ya locomotor muyeso lokwezeka la maze-maze, kutanthauza zotsatira zotsutsana ndi nkhawa.
• Ulamuliro wa Noopept unawonjezeranso khalidwe lofufuza makoswe omwe amayesedwa poyera, zomwe zimasonyeza kuchepetsa nkhawa.
• Mu mbewa, kuyang'anira kwa Noopept kunapanga kusintha kwa mlingo wa nkhawa.
• Mu makoswe, Noopept anachepetsa zochitika za kusowa thandizo lophunzira.
• Mu mbewa zochokera kumagulu osiyanasiyana, Noopept inachepetsa kupsinjika maganizo monga momwe zikuwonetsedwera ndi kuchuluka kwa zochitika zopewera muyeso-kuyambitsa kupanikizika.
• Mu makoswe omwe ali ndi masiku a 4, Noopept anasintha zizindikiro za kupsinjika maganizo komwe kumayambitsidwa ndi corticotropin releasing hormone (CRH).
• M'magulu amtundu wa mbewa, kayendetsedwe ka Noopept pa 1 mg pa kg tsiku ndi tsiku kunapanga zotsatira zotsutsana ndi nkhawa pa tsiku la 7.

Kuwongolera Mood

Noopept ingathandizenso kusintha maganizo, ndikupangitsa kukhala njira yochizira matenda ena amisala:

• Ulamuliro wautali wa Noopept (masiku 21) unathetsa kwambiri mawonetseredwe a kusowa thandizo lophunzira poyerekeza ndi mankhwala odana ndi nkhawa Afobazol.
• Ulamuliro wanthawi zonse (masiku 28, 0.5 mg / tsiku kudzera mu jekeseni) wa Noopept khalidwe labwino mwa kuchepetsa ntchito ya kinases yochititsa chidwi (yomwe imakhudzidwa ndi matenda a maganizo) ndikuwonjezera milingo ya BDNF.

Mwachidule, Noopept ndi gulu lodalirika lomwe lingakhale ndi phindu lachidziwitso, nkhawa, ndi maganizo. Aogubio ndi gwero lodalirika la Noopept yapamwamba kwambiri ndi zinthu zina zogwiritsira ntchito pharmacologically, kuonetsetsa kuti makasitomala ali ndi mwayi wopeza mayankho odalirika, ogwira ntchito pa thanzi lawo ndi thanzi lawo. Kaya amagwiritsidwa ntchito muzowonjezera, mankhwala, kapena ntchito zina, Noopept ali ndi kuthekera kopanga kusiyana kwakukulu m'miyoyo ya ogwiritsa ntchito. Pomwe kufunikira kwa zida zachidziwitso zachilengedwe kukukulirakulira, AoguBio idakali yodzipereka kupereka zinthu zatsopano kuti zikwaniritse zosowa za makasitomala athu.

Kulemba nkhani: Miranda Zhang