Mphamvu Yachilitso ya N-Acetylcysteine ​​​​kwa Matenda Opweteka Kwambiri

Kutupa kosatha kumatha kufooketsa, kubweretsa ululu, kusapeza bwino, komanso kuchepa kwa moyo kwa omwe akukhudzidwa. Thandizo lachikhalidwe nthawi zambiri limayang'ana pakuwongolera zizindikiro m'malo mothana ndi zomwe zimayambitsa kutupa. Komabe, pali kafukufuku wochuluka wosonyeza kuti ufa wa N-Acetylcysteine ​​(NAC) ukhoza kukhala ndi chinsinsi choyang'anira komanso kuchiritsa matenda aakulu otupa.

N-Acetylcysteine ​​ndi antioxidant wamphamvu komanso kalambulabwalo wa glutathione, antioxidant wamphamvu yopangidwa mwachilengedwe m'thupi. Glutathione imagwira ntchito yofunika kwambiri pochepetsa kupsinjika kwa okosijeni komanso kuthana ndi kutupa. Komabe, matenda ena otupa, monga nyamakazi ya nyamakazi ndi matenda otupa m'matumbo, amatha kutsitsa kuchuluka kwa glutathione m'thupi, kukulitsa kutupa.

Kuwonjezera ndi ufa wa N-Acetylcysteine ​​​​kwawonetsa zotsatira zabwino mu maphunziro osiyanasiyana, kusonyeza mphamvu yake yochepetsera kutupa. Kafukufuku wofalitsidwa mu nyuzipepala ya Free Radical Biology and Medicine anapeza kuti NAC ikhoza kuchepetsa kwambiri zizindikiro za kutupa kwa odwala matenda a nyamakazi. Kafukufuku wina wofalitsidwa mu American Journal of Physiology-Gastrointestinal and Liver Physiology anasonyeza kuti NAC ingateteze ku kutupa kwa m'mimba mu mbewa.

Imodzi mwa njira zomwe N-Acetylcysteine ​​​​imagwiritsa ntchito zotsutsana ndi zotupa ndi kusintha ntchito ya nyukiliya-kappa B (NF-κB), puloteni yofunika kwambiri yomwe imaphatikizapo kulamulira majini omwe amachititsa kutupa. NAC imalepheretsa NF-κB, kuteteza kupanga mamolekyu oletsa kutupa komanso kuchepetsa kutupa kwa thupi lonse.

Komanso, N-Acetylcysteine ​​​​ili ndi katundu wa mucolytic, ndikupangitsa kuti ikhale yogwira mtima pakuwongolera matenda osapumira monga matenda osachiritsika a pulmonary (COPD) ndi mphumu. Pothyola ndi kupatulira ntchofu, NAC imathandizira kukonza magwiridwe antchito am'mapapo ndikuchepetsa zizindikiro zokhudzana ndi izi.

Kuphatikiza pa zotsutsana ndi zotupa, N-Acetylcysteine ​​​​yawonetsa kuthekera kochiza matenda amisala okhudzana ndi kutupa. Mu kafukufuku wofalitsidwa mu JAMA Psychiatry, ofufuza adapeza kuti NAC supplementation imachepetsa zizindikiro za kuvutika maganizo kwa anthu omwe ali ndi matenda ochititsa munthu kusinthasintha maganizo. Kafukufukuyu adawonetsa kuti kuthekera kwa NAC kosinthira glutamate, neurotransmitter yomwe imakhudzidwa ndi kuvutika maganizo, kungathandize kuti maganizo ake azikhala okhazikika.

Ngakhale kuti ufa wa N-Acetylcysteine ​​​​umasonyeza lonjezano lalikulu pochepetsa kutupa kosalekeza, ndikofunikira kuti mufunsane ndi katswiri wa zachipatala musanawaphatikize mu mankhwala anu. Atha kukupatsani chitsogozo pa mlingo woyenera ndikuthandizira kuwunika momwe mukuyendera.

Ndikoyenera kudziwa kuti ngakhale NAC nthawi zambiri imakhala yotetezeka, Mlingo waukulu komanso kugwiritsa ntchito nthawi yayitali kumatha kubweretsa zotsatira zoyipa monga kusapeza bwino m'mimba komanso kusamvana. Kuphatikiza apo, anthu omwe ali ndi mphumu kapena mbiri ya khunyu ayenera kusamala akamaganizira za NAC supplementation.

Pomaliza, ufa wa N-Acetylcysteine ​​​​umakhala ndi kuthekera kwakukulu pakuwongolera zovuta zotupa. Pochepetsa kutupa ndi kupsinjika kwa okosijeni ndikusintha mapuloteni ofunikira omwe amakhudzidwa ndi kutupa, NAC imatha kupereka mpumulo ndikuwongolera moyo wabwino wa anthu omwe akudwala matendawa. Komabe, ndikofunikira kugwirira ntchito limodzi ndi katswiri wazachipatala kuti muwonetsetse kuti mukugwiritsa ntchito bwino ufa wa N-Acetylcysteine ​​monga gawo la dongosolo lanu lamankhwala.