N-Acetylcysteine nubushobozi bwayo mukurinda kwangirika kwumwijima watewe numwijima
N-Acetylcysteine (NAC) isanzwe iboneka muri capsule cyangwa ifu yifu kandi imaze kumenyekana kubushobozi ifite mukurinda kwangirika kwumwijima guterwa nibiyobyabwenge. Umwijima ni urugingo rukomeye rushinzwe guhinduranya imiti nuburozi, kandi kumara igihe kinini kumiti imwe n'imwe bishobora gukomeretsa umwijima. Muri iki kiganiro, tuzasuzuma ibyiza bya N-Acetylcysteine nuburyo ishobora kurinda umwijima kwangirika kwatewe nibiyobyabwenge.
N-Acetylcysteine, ibanziriza aside aside amine, izwiho kurwanya antioxydeant. Ikora yuzuza glutathione, antioxydants ikomeye isanzwe iboneka mumubiri, bityo ikarinda selile guhagarika umutima. Ubu buryo bwibikorwa butuma NAC umukandida utanga ikizere cyo gukumira ibikomere byatewe n’umwijima, kubera ko umwuka wa okiside ugira uruhare runini mu iterambere ry’umwijima.
Ubushakashatsi bwinshi bwerekanye ubushobozi bwa N-Acetylcysteine mukurinda kwangirika kwumwijima guterwa n'imiti itandukanye. Kurugero, acetaminofeni (paracetamol) ni analgesic ikoreshwa cyane ishobora gukomeretsa umwijima cyane mugihe kirenze urugero. NAC yerekanwe kugabanya neza hepatotoxicite iterwa na acetaminofeni ikingira glutathione igabanuka, kugabanya imihangayiko ya okiside, no kugabanya umusaruro wa metabolite yuburozi.
Usibye acetaminofeni, indi miti nka nonsteroidal anti-inflammatory (NSAIDs), statine, na antibiotike zimwe na zimwe zajyanye na hepatotoxicity. N-Acetylcysteine yerekanye amasezerano yo gukingira umwijima watewe niyi miti. Muguhindura metabolite yuburozi, kugabanya uburibwe, no guteza imbere ingirabuzimafatizo yumwijima, NAC irashobora gukumira iterambere ryangirika ryumwijima uterwa nibiyobyabwenge kandi bikarinda imikorere yumwijima.
Byongeye kandi, N-Acetylcysteine yakozweho ubushakashatsi ku kamaro kayo mu gukumira kwangirika kw umwijima ku bantu bafite uburwayi runaka. Kurugero, abantu barwaye hepatite C idakira bakunze guhura nibibazo byinshi byo kwandura fiboside yumwijima na cirrhose. Ubushakashatsi bwerekanye ko inyongera ya NAC ishobora kunoza imikorere yumwijima muri aba barwayi, kuko ifasha kugabanya gucana no guhagarika umutima.
Usibye imiterere irinda umwijima, N-Acetylcysteine yakozweho ubushakashatsi ku bushobozi ifite mu kuvura izindi ndwara nk'indwara z’ubuhumekero, indwara zo mu mutwe, no kunywa ibiyobyabwenge. Yakoreshejwe nk'umuti wa mucolytique mu bihe nk'indwara zidakira zifata ibihaha (COPD) na fibrosis ya cystic, aho ifasha kumena ururenda no kunoza imyuka ihumeka. Byongeye kandi, NAC yerekanye amasezerano mu gucunga indwara zo mu mutwe nka bipolar disorder ndetse n’indwara idahwitse bitewe n’uruhare rwayo mu guhindura glutamate mu bwonko.
Mu gusoza, N-Acetylcysteine muri capsule cyangwa ifu ifu ifite ubushobozi bwo kwirinda umwijima watewe numwijima. Imiterere ya antioxydeant hamwe nubushobozi bwo kuzuza glutathione bituma iba umukandida mwiza mukugabanya imbaraga za okiside no kugabanya imvune yumwijima iterwa n'imiti imwe n'imwe. Byongeye kandi, NAC yerekanye amasezerano mu kuvura izindi ndwara z’ubuvuzi nk’ubuhumekero n’indwara zo mu mutwe. Nyamara, ni ngombwa kugisha inama inzobere mu buvuzi mbere yo gutangira inyongera ya N-Acetylcysteine kuko hashobora kubaho itandukaniro ryihariye muri dosiye kandi ikwiranye.
Ibisobanuro ku bicuruzwa
N-acetyl cysteine (NAC) ikomoka kuri aside amine L-cysteine. Acide Amino yubaka proteine. NAC ifite byinshi ikoresha kandi ni imiti yemewe na FDA.
N-acetyl cysteine ni antioxydeant ishobora kugira uruhare mukurinda kanseri. Nibiyobyabwenge, bikoreshwa nabashinzwe ubuvuzi mu kuvura uburozi bwa acetaminofeni (Tylenol). Ikora muguhuza ubwoko bwuburozi bwa acetaminofeni iba mu mwijima.
Abantu bakunze gukoresha N-acetyl cysteine mugukorora nibindi bihe by ibihaha. Irakoreshwa kandi mubicurane, ijisho ryumye, nibindi bihe byinshi, ariko nta bimenyetso bifatika bya siyansi byemeza byinshi muribi bikoreshwa. Nta bimenyetso bifatika byemeza ukoresheje N-acetyl cysteine kuri COVID-19.
N-Acetyl-L-Cysteine ni aside amine, irashobora guhinduka kuva mumubiri wa methionine, cystine irashobora guhinduka hamwe. N-Acetyl-l-cysteine irashobora gukoreshwa nkumuti wa mucilagenic. Birakwiriye kubuza guhumeka biterwa nubwinshi bwikibuza. Byongeye kandi, irashobora kandi gukoreshwa mugukuraho uburozi bwa acetaminofeni.
Imikorere
N-Acetyl-L-Cysteine ni aside amine, irashobora guhinduka kuva mumubiri wa methionine, cystine irashobora guhinduka hamwe. N-Acetyl-l-cysteine irashobora gukoreshwa nkumuti wa mucilagenic. Birakwiriye kubuza guhumeka biterwa nubwinshi bwikibuza. Byongeye kandi, irashobora kandi gukoreshwa mugukuraho uburozi bwa acetaminofeni.
