Mu isi ya farumasi nintungamubiri, Noopept irimo kwitabwaho nkibishobora kongera ubumenyi bwubwenge na neuroprotectant. Aogubio nisosiyete ikomeye izobereye mu gukora no kugurisha ibintu bikora imiti, ibikoresho fatizo nibikomoka ku bimera, harimo Noopept. Umuti wa sintetike wateguwe nisosiyete yo mu Burusiya, Noopept bakunze kwita nootropique kubera ubushobozi bwayo bwo kongera ubwenge. Muri iyi blog, tuzasesengura ibyiza n'imikoreshereze ya Noopept, hamwe n'ingaruka zishobora kugira ku mikorere y'ubwenge n'ubuzima muri rusange.
Noopept ni iki?
Noopept, izwi kandi nka N-phenylacetyl-L-prolylglycine ethyl ester, ni uruganda rwigwa kubushobozi bwarwo bwo kunoza imikorere yubwenge no kurwanya amaganya. Imiterere ya Noopept ishingiye kuri Piracetam, indi izwi cyane ya nootropique, yerekanwe ko ifite imitekerereze ya neuroprotective kandi ishobora kugira ingaruka nziza mukwibuka no kwiga. Aogubio iri ku isonga mu gutanga Noopept yo mu rwego rwo hejuru kugira ngo ikoreshwe mu nyongera, mu bya farumasi no mu zindi nganda.
Uburyo Noopept ikora
Noopept numuti uzwi cyane wongera ubwenge-wongera ubwenge ukora mukwihutisha inzira yo kwibuka no kugarura. Irabikora mukuzamura urwego rwibintu bikomoka mu bwonko biva mu bwonko (BDNF), uruganda ruteza imbere imikurire yubwonko. Nanone, Noopept ituma reseptor ya acetylcholine (ACh) mu bwonko irushaho kwitabira neurotransmitter (chimique y'ubwonko) acetylcholine, nayo ikaba itanga ubutumwa bwihuse kandi bunoze bwo gutanga ubutumwa hagati ya neuron.
Inyungu za Noopept
Kunoza imikorere yo kumenya
Umubare munini wibimenyetso byubuvuzi bishyigikira inyungu za Noopept mubice bitandukanye byimikorere yubwenge nko kwibuka, kwiga, hamwe nubushobozi bwo gutekereza:
- Ku barwayi bafite ihungabana ryubwenge riterwa nihungabana cyangwa indwara zubwonko bwamaraso, Noopept yatezimbere imikorere yubwonko nkuko bigaragazwa nimbaraga za alpha- na beta-rhythms muri electroencephalogramme (EEG).
- Ubuyobozi bwa Noopept ku kigero cya 20 mg buri munsi mumezi 2 bwatezimbere imikorere yubwenge kubarwayi bafite ubwonko kandi ifite umutekano murwego rwo hejuru.
- Mu buryo butandukanye bw’inyamaswa z’indwara ya Alzheimer (AD), Noopept yarinze ingirabuzimafatizo z’ubwonko bw’ubumara bwangiza amyloide beta (agent ya causative ya AD) mu kubuza kwangiza okiside, kwirinda calcium irenze urugero, no guhagarika apoptose (urupfu rwa selile).
- Gusubiramo umunwa kwa Noopept mu mbeba byateje imbere imyigire ugereranije numuti umwe.
- Mu mbeba yimbeba yubwonko, Noopept yerekanye ibintu byombi bigarura ubwenge hamwe na neuroprotective.
- Muri syndrome isanzwe na Down ubwonko bwubwonko bwabantu, Noopept yarinze kwangiza okiside na apoptose.
- Imbeba zizi, ubuyobozi bwa Noopept bwongereye ibikorwa byubwonko muri EEG.
- Noopept ifite ubushobozi bwo kongera urwego rwa Nerv Growth Factor na Brain Derived Neurotrophic Factor, ifitanye isano no kunoza karande mumutwe.
- Noopept irashobora gufasha kunoza imikorere yubwenge mukuzamura ibimenyetso byamashanyarazi hagati ya neuron.
- Noopept ku kigereranyo cya 1: 1 cyangwa inshuro icumi zirenga byagaragaye ko igabanya cyane urwego rwimibiri ya Lewy (proteine clumps itera indwara ya Parkinson) mubwonko.
- Imbeba zifite ikibazo cyo guhungabana, ubuyobozi bwa karande bwa Noopept bwongereye imbaraga za anticonvulsant ibiyobyabwenge valproate.
- Ubushakashatsi bwerekanye ko Noopept igira ingaruka zayo mu bwonko ikoresheje antioxydeant na anti-inflammatory.
- Imbeba, Noopept yongereye kwanduza ibimenyetso byubwonko mu bwonko.
- Imbeba, Noopept yabujije rwose iterambere ryindwara ziterwa na scopolamine.
- Imbeba, Noopept yahinduye ubumuga bwo kutamenya yongera urwego rwibintu bikomoka mu bwonko biva mu bwonko (BDNF).
- Muburyo bwimbeba yindwara ya Alzheimer, Noopept yabujije kwibuka nabi.
- Ubushakashatsi bwerekanye ko Noopept ishobora gufasha kwirinda indwara ya Alzheimer mu kubuza imiterere ya poroteyine idasanzwe mu bwonko no kugabanuka mu bikorwa by’imikorere ya vitamine ikora poroteyine ikora (MAPK).
- Imbeba, inshinge ya Noopept iminota 5 mbere yo kwiga kunoza kwibuka igihe kirekire.
- Imbeba zifite ubwonko, kuvura Noopept byagabanije agace ka infarction (tissue yapfuye) mubwonko.
- Imbeba, ubuyobozi bwa Noopept kuri 5 mg / kg hakoreshejwe inshinge byatanze ingaruka zo kongera ubwenge.
- Ubuyobozi bwa 0.5-10 mg / kg ya Noopept mu mbeba bwashishikarije kwiga isomo rimwe nyuma yubuyobozi bumwe, mugihe ubuyobozi bwagiye busubiramo bwongerera ubushobozi bwo kwiga imbeba zatsinzwe imyitozo yambere mugikorwa cyo kwirinda gusa (ikizamini gisuzuma imyigire nibuka) .
- Ubuyobozi bwa Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) ku gipimo cya 0.5 mg / kg iminota 15 mbere yuko Morris maze itangira itera intambwe ishimishije mu kwibuka igihe kirekire.
- Imbeba zifite ischemia yubwonko iterwa no kwikuramo, ubuyobozi bwa Noopept hakoreshejwe inshinge ninzira yo munwa byanonosoye ibisubizo byokwirinda gusa.
- Ubushakashatsi bwakozwe mu ngirabuzimafatizo bwerekanye ko Noopept yakumiriye neurodegeneration iterwa na glutamate na stress ya okiside.
- Imbeba zari zifite ubumuga bwo kutamenya bitewe na lobectomy, inzira ikubiyemo kuvanaho igice cyose cyubwonko, Noopept yateje imbere kugarura imyigire no kwibuka.
- Ubushakashatsi bwakorewe mu kagari bwatangaje ko Noopept yongereye uburyo bwo kohereza ibimenyetso hagati y’ingirabuzimafatizo.
Kurwanya Amaganya
- Ubushobozi bwa Noopept bwo kongera ubwenge nabwo butanga ingaruka zo kurwanya amaganya ukurikije ubushakashatsi:
- Ubuyobozi bwa Noopept kubarwayi bafite ubumuga bwubwenge buke bwagabanije umunaniro, guhangayika, no kurakara.
- Ku barwayi barwaye igituntu gishya cy'ubuhumekero, kuvura Noopept byagabanije kwigaragaza.
- Imbeba, ubuyobozi bwa Noopept bwagize uruhare mu kongera ibikorwa bya lokomoteri mu kizamini cyongeweho plus-maze, byerekana ingaruka zo kurwanya amaganya.
- Ubuyobozi bwa Noopept kandi bwongereye imyitwarire yubushakashatsi bwimbeba zipimwa kumurima, ibyo bikaba byerekana guhangayika.
- Imbeba, ubuyobozi bwa Noopept bwatanze modulisiyo yurwego rwo guhangayika.
- Imbeba, Noopept yagabanije ikibazo cyo kutagira kirengera.
- Imbeba ziva muburyo butandukanye, Noopept yagabanije urwego rwo guhangayika nkuko bigaragazwa nubwiyongere bwimyitwarire yo kwirinda mukibazo gitera kunyerera.
- Imbeba zifite iminsi 4, Noopept yahinduye ibimenyetso byikibazo cyatewe na corticotropine irekura imisemburo (CRH).
- Mu mbeba zororoka, ubuyobozi bwa Noopept kuri mg 1 kuri kg buri munsi byatanze ingaruka zo kurwanya amaganya kumunsi wa 7.
Itezimbere
Noopept irashobora kandi gufasha kunoza imyumvire, bigatuma ishobora kuba uburyo bwo kuvura indwara zimwe na zimwe z’ubuzima bwo mu mutwe:
- Ubuyobozi bwigihe kirekire Noopept (iminsi 21) bwakuyeho cyane kwigaragaza kwabatishoboye wize ugereranije nibiyobyabwenge birwanya Afobazol.
- Imiyoborere idakira (iminsi 28, 0.5 mg / kumunsi ukoresheje inshinge) za Noopept yahinduye imyitwarire igabanya ibikorwa bya kinase iterwa no guhangayika (igira uruhare mubibazo byo mumutwe) no kongera urwego rwa BDNF.
Muncamake, Noopept ningingo itanga ibyiringiro hamwe ninyungu zishobora guterwa mumikorere yubwenge, guhangayika, hamwe numutima. Aogubio ni isoko yizewe yo mu rwego rwohejuru Noopept hamwe nibindi bintu bikora imiti, bituma abakiriya babona ibisubizo byizewe, bifatika kubuzima bwabo no mubuzima bwiza. Yaba ikoreshwa mubyongeweho, imiti, cyangwa izindi progaramu, Noopept ifite ubushobozi bwo guhindura ibintu bifatika mubuzima bwabakoresha. Mugihe icyifuzo cyabazamura ubwenge busanzwe gikomeje kwiyongera, AoguBio ikomeje kwiyemeza gutanga ibicuruzwa bishya kugirango duhuze ibyifuzo byabakiriya bacu.
Kwandika ingingo: Miranda Zhang
Igihe cyo kohereza: Werurwe-11-2024
