Imbaraga zo gukiza za N-Acetylcysteine ​​kumiterere idakira

Indwara zidakira zirashobora kuba intege nke, bigatera ububabare, kutamererwa neza, ndetse nubuzima bugabanuka kubabigizemo uruhare. Ubuvuzi gakondo bwibanda ku gucunga ibimenyetso aho gukemura impamvu nyamukuru itera. Nyamara, hari ubushakashatsi bugenda bwiyongera bwerekana ko ifu ya N-Acetylcysteine ​​(NAC) ishobora gufata urufunguzo rwo gucunga ndetse no gukiza indwara zidakira.

N-Acetylcysteine ​​ni antioxydants ikomeye kandi ibanziriza glutathione, antioxydants ikomeye ikorwa bisanzwe mumubiri. Glutathione igira uruhare runini mukugabanya imbaraga za okiside no kurwanya umuriro. Nubwo bimeze bityo ariko, indwara zimwe na zimwe zidakira, nka rubagimpande ya rubagimpande nindwara zifata amara, zirashobora kugabanya urugero rwa glutathione yumubiri, bikongerera umuriro.

Kuzuza ifu ya N-Acetylcysteine ​​yerekanye ibisubizo bitanga umusaruro mubushakashatsi butandukanye, byerekana akamaro kayo mukugabanya umuriro. Ubushakashatsi bwasohotse mu kinyamakuru Free Radical Biology and Medicine bwerekanye ko NAC ishobora kugabanya cyane ibimenyetso byerekana umuriro ku barwayi barwaye rubagimpande. Ubundi bushakashatsi bwasohotse mu kinyamakuru cyo muri Amerika cyitwa Physiology-Gastrointestinal na Liver Physiology bwerekanye ko NAC ishobora kwirinda indwara ziterwa na gastrointestinal mu mbeba.

Bumwe mu buryo N-Acetylcysteine ​​ikoresha mu kurwanya ingaruka zayo ni uguhindura ibikorwa bya kirimbuzi-kappa B (NF-κB), poroteyine y'ingenzi igira uruhare mu kugenzura ingirabuzimafatizo zigira uruhare mu gutwika. NAC ibuza NF-κB, ikabuza gukora molekile ziterwa no gutwika no kugabanya umuriro muri rusange.

Byongeye kandi, N-Acetylcysteine ​​ifite imitekerereze ya mucolytike, bigatuma ikora neza mugucunga imiterere yubuhumekero idakira nkindwara zidakira zifata ibihaha (COPD) na asima. Mugusenya no kunanura ururenda, NAC ifasha kunoza imikorere yibihaha no kugabanya ibimenyetso bifitanye isano nibi bihe.

Usibye imiti igabanya ubukana, N-Acetylcysteine ​​yerekanye ubushobozi bwo kuvura indwara zo mu mutwe zijyanye no gutwika. Mu bushakashatsi bwasohotse muri JAMA Psychiatrie, abashakashatsi basanze inyongera ya NAC yagabanije ibimenyetso byo kwiheba ku bantu bafite ikibazo cya bipolar. Ubushakashatsi bwagaragaje ko ubushobozi bwa NAC bwo guhindura glutamate, neurotransmitter igira uruhare mu kwiheba, bishobora kugira uruhare mu ngaruka zabyo.

Nubwo ifu ya N-Acetylcysteine ​​yerekana amasezerano akomeye mu kugabanya indwara zidakira, ni ngombwa kubaza inzobere mu by'ubuzima mbere yo kuyishyira mu bikorwa byo kuvura. Barashobora gutanga ubuyobozi kubijyanye na dosiye ikwiye kandi bagufasha gukurikirana iterambere ryawe.

Birakwiye ko tumenya ko mugihe NAC ifite umutekano muri rusange, dosiye nyinshi no kuyikoresha igihe kirekire bishobora gutera ingaruka mbi nko kubura gastrointestinal na allergique. Byongeye kandi, abantu bafite asima cyangwa amateka yo gufatwa bagomba kwitonda mugihe batekereza ku nyongera ya NAC.

Mu gusoza, ifu ya N-Acetylcysteine ​​ifite imbaraga zikomeye mugucunga indwara zidakira. Mugabanye gucana no guhagarika umutima no guhindura poroteyine zingenzi zigira uruhare mugukiza umuriro, NAC irashobora gutanga ubutabazi no kuzamura imibereho rusange yabantu bafite ibibazo. Ariko, ni ngombwa gukorana cyane ninzobere mu buvuzi kugira ngo ukoreshe neza kandi neza ifu ya N-Acetylcysteine ​​muri gahunda yawe yo kuvura.