Lisele tsohle tse phelang li na lenicotinamide adenine dinucleotide kapa NAD+. E na le nucleotides nicotinamide mononucleotide (NMN) le adenosine diphosphate (ADP), tse kopantsoeng ke pyrophosphate linkage. NAD+ e kanna ea fetoha habonolo lipakeng tsa eona e fokotsehileng (NADH) le oxidized (NAD +) ho latela lits'ebetso tsa redox tseo e nkang karolo ho tsona.
NAD+ e sebetsa e le karolo ea bohlokoa lits'ebetsong tse fapaneng tsa cellular, ho kenyelletsa metabolism ea matla, tokiso ea DNA le pontšo ea lisele. Ho kenya letsoho ha eona lits'ebetsong tsena haholo-holo ka karolo ea eona e le sejari sa elektrone, se koalang lielektrone lipakeng tsa limolek'hule nakong ea karabelo ea redox.
NAD + Tsela ea Metabolic
NAD+ metabolism e kenyelletsa marang-rang a rarahaneng a litsela tsa biosynthetic le salvage. The de novo biosynthesis ea NAD + e qala ka amino acid tryptophan kapa nicotinic acid e le li-precursors, qetellong e fella ka ho thehoa ha NMN, e ntan'o fetoloa NAD +. Ntle le moo, lisele li ka pholosa NAD+ ka ho sebelisa limolek'hule tse tlang pele, joalo ka nicotinamide kapa nicotinic acid riboside, e fetoloang ho NMN ebe NAD+.
Tsela ea pholoso e bohlokoa ka ho khetheha ho bolokeng maemo a NAD+, haholo-holo nakong ea maemo a tlhokahalo e phahameng ea matla kapa ho fumaneha ha selelekela pele. E lumella lisele ho sebelisa hape le ho sebelisa limolek'hule tsa NAD + hape, ho thibela ho fokotseha ha tsona le ho netefatsa phepelo e tsoelang pele bakeng sa lits'ebetso tsa bohlokoa tsa metabolic.
Melemo e ka Tsoang
NAD+ e bohlokoa bakeng sa tlhokomelo ea mefuta ea mitochondrial le taolo ea liphatsa tsa lefutso mabapi le botsofali. Leha ho le joalo, boemo ba NAD + 'meleng ea rona bo fokotseha haholo ka lilemo. "Ha re ntse re tsofala, re lahleheloa ke NAD +. Ha u le lilemo li 50, u se u e-na le hoo e ka bang halofo ea tekanyo eo u kileng ua ba le eona ha u le lilemo li 20,” ho boletse David Sinclair oa Univesithi ea Harvard puisanong le eena.
Boithuto bo bontšitse ho fokotseha ha molek'hule e amanang le mafu a amanang le botsofali ho kenyelletsa botsofali bo potlakileng, mathata a metabolism, lefu la pelo le neurodegeneration. Maemo a tlase a NAD + a amahanngoa le lefu le amanang le lilemo ka lebaka la metabolism e sa sebetseng hantle. Empa ho tlatsa maemo a NAD + ho hlahisitsoe
liphello tse khahlanong le botsofali mefuteng ea liphoofolo, tse bontšang liphello tse tšepisang ho khutlisa maloetse a amanang le lilemo, ho eketsa nako ea bophelo le bophelo bo botle.
- Ho tsofala
Li tsejoa e le “bahlokomeli ba liphatsa tsa lefutso,” li-sirtuin ke liphatsa tsa lefutso tse sireletsang lintho tse phelang, ho tloha ho limela ho ea ho liphoofolo tse anyesang, khahlanong le ho senyeha le maloetse. Ha liphatsa tsa lefutso li utloa 'mele o le tlas'a khatello ea 'mele, e kang ho ikoetlisa kapa tlala, e romela masole ho sireletsa' mele. Li-Sirtuins li boloka botšepehi ba genome, li khothalletsa tokiso ea DNA 'me li bontšitse thepa e khahlanong le botsofali liphoofolong tsa mohlala tse kang ho eketseha ha nako ea bophelo.
NAD + ke mafura a etsang hore liphatsa tsa lefutso li sebetse. Empa joalo ka ha koloi e sa khone ho khanna ntle le mafura a eona, li-sirtuin li hloka NAD +. Liphetho tse tsoang lithutong li bonts'a hore ho phahamisa boemo ba NAD+ 'meleng ho kenya li-sirtuin mme ho eketsa nako ea bophelo ho tomoso, liboko le litoeba. Leha ho tlatsa NAD+ ho bonts'a liphetho tse ts'episang mefuteng ea liphoofolo, bo-ramahlale ba ntse ba ithuta hore na liphetho tsena li ka fetolela batho joang.
- Mosebetsi oa mesifa
Joalo ka matla a 'mele, ts'ebetso ea mitochondrial e bohlokoa bakeng sa ts'ebetso ea rona ea boikoetliso. NAD+ ke e 'ngoe ea linotlolo tsa ho boloka mitochondria e phetseng hantle le tlhahiso e tsitsitseng ea matla.
Ho eketsa maemo a NAD + mesifa ho ka ntlafatsa mitochondria le ho phela hantle ho litoeba. Lithuto tse ling li boetse li bonts'a hore litoeba tse nkang li-booster tsa NAD + li tšesaane 'me li ka matha ho ea pele holim'a treadmill, li bonts'a matla a holimo a boikoetliso. Liphoofolo tse tsofetseng tse nang le boemo bo phahameng ba NAD+ li feta lithaka tsa tsona.
- Mathata a metabolism
Ho boleloa hore ke seoa ke Mokhatlo oa Lefatše oa Bophelo (WHO), botenya ke bo bong ba mafu a atileng haholo sechabeng sa kajeno. Botenya bo ka lebisa mathateng a mang a metabolism a kang lefu la tsoekere, le bolaileng batho ba limilione tse 1.6 lefatšeng ka bophara ka 2016.
Lijo tsa botsofali le mafura a mangata li fokotsa boemo ba NAD + 'meleng. Boithuto bo bonts'itse hore ho nka li-booster tsa NAD+ ho ka fokotsa boima ba 'mele bo amanang le lijo le lilemo ho litoeba le ho ntlafatsa bokhoni ba bona ba boikoetliso, leha litoeba tse tsofetseng. Lithuto tse ling li bile tsa fetola phello ea lefu la tsoekere ho litoeba tse tšehali, tse bonts'ang maano a macha a ho loants'a mathata a metabolism.
- Mosebetsi oa pelo
Ho saroloha ha methapo ea mali ho sebetsa e le tšireletso pakeng tsa maqhubu a khatello a romeloang ke ho otla ha pelo. Empa methapo ea mali e satalla ha re ntse re tsofala, e leng se tlatsetsang khatellong e phahameng ea mali, e leng mabaka a bohlokoa ka ho fetisisa a kotsi bakeng sa lefu la pelo. CDC e tlaleha hore motho a le mong o bolaoa ke lefu la pelo metsotsoana e meng le e meng e 37 United States feela.
Khatello e phahameng ea mali e ka baka pelo e atolositsoeng le ho thiba methapo ea mali e lebisang ho stroke. Ho phahamisa maemo a NAD + ho fana ka tšireletso pelong, ho ntlafatsa tšebetso ea pelo. Ho litoeba, li-boost tsa NAD+ li tlatsitse maemo a NAD+ ka pelong ho ea maemong a mantlha le ho thibela likotsi tse tsoang pelong tse bakoang ke khaello ea phallo ea mali. Liphuputso tse ling li bonts'itse hore li-booster tsa NAD + li ka sireletsa litoeba ho atolosong e sa tloaelehang ea pelo.
- Neurodegeneration
Ka 2050, palo ea baahi ba lefatše ba lilemo tse 60 le ho feta e lebelletsoe ho ba limilione tse likete tse peli, e leng palo e batlang e imena habeli ea 2015, ho latela WHO. Batho lefatšeng ka bophara ba phela nako e teletsana. Leha ho le joalo, botsofali ke sesosa se ka sehloohong sa kotsi bakeng sa mafu a mangata a neurodegenerative ho kenyelletsa lefu la Parkinson le Alzheimer's, a bakang ho se sebetse hantle ha kelello.
Ho litoeba tse nang le Alzheimer's, ho phahamisa boemo ba NAD+ ho ka fokotsa ho bokellana ha protheine e sitisang puisano ea sele le ho eketsa ts'ebetso ea kelello. Ho eketsa maemo a NAD + ho boetse ho sireletsa lisele tsa boko hore li se ke tsa shoa ha ho se na phallo e lekaneng ea mali bokong. Lithuto tse ngata mefuteng ea liphoofolo li fana ka menyetla e mecha ea ho thusa boko hore bo tsofale bo phetse hantle le ho itšireletsa khahlanong le neurodegeneration.
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Nako ea poso: Dec-26-2023
