10 Izinzuzo Zezempilo Ezimangazayo ze-Akuamma

I-Akuamma, eyaziwa nangokuthi i-Picralima Nitida, ivela esihlahleni esifana nesihlahla (esifana ngobude nezitshalo ze-Kratom) esimila osebeni lomfula eNtshonalanga Afrika. Ama-alkaloid amakhulu akhona embewini ye-Akuamma i-Akuammine ne-Pericine - yomibili iqhathaniswa ne-Mitragynine e-Kratom.

Ngoba i-Akuamma ifana ngezindlela eziningi - imiphumela yokuthatha i-Akuamma Seed nayo ifana kakhulu nokudla amaqabunga e-Kratom.

I-alkaloids eyinhloko eyenza isitshalo sibe namandla kakhulu futhi siphumelele zihlanganisa;

• I-Akuammidine- lena i-alkaloid eyinhloko yembewu futhi isebenza ngokuba nomthelela kumasayithi okubopha ama-opioid. I-alkaloid inikeza izimfanelo ze-analgesic ukusiza ekuqedeni ubuhlungu kanye nokusebenza njengesiphumuli semisipha.
• I-Akuammine- le alkaloid inokuhlobana okuphezulu kwezindawo zokubopha i-mu-opioid, ngokungafani ne-Akuammidine. Kuyasiza ngokuhlinzeka ngemiphumela ye-analgesic, nokho, kungabangela umthelela ovimbelayo ekuhambeni kwe-peristaltic yamathumbu uma kusetshenziswa imithamo ephezulu.
• I-Akuammicine- le alkaloid, ngakolunye uhlangothi, inobudlelwane obuphezulu bezindawo zokubopha i-kappa-opioid.
• I-Pseudo-Akuammigine- le alkaloid inikeza kokubili imiphumela elwa nokuvuvukala kanye ne-analgesic. Kuye ngesilinganiso, i-alkaloid iyajabulisa, iguqule ukufinyela kwemisipha yamathambo, ukufinyela kwemisipha ebushelelezi, isimiso sezinzwa esimaphakathi, nokuphefumula.
• I-Akuammigine- lena ibonise kuphela ukuthi inomphumela wokulwa ne-adrenergic emithanjeni yegazi kanye nasenhliziyweni.
• I-Pericine- lena kukhonjiswe ukuthi ibophezela kuma-mu-opioid receptors, nokho, ingabangela ukudlikizeka okuholela ekufinyezweni kwemisipha okungahleliwe.

I-Akuamma namuhla ibhekwa njengenye indlela engcono kunezinye izinto ezinokhahlo njengoba iqinisekisa ukukhululeka kobuhlungu okuphelele. Lokhu kuphinde kwagqugquzela ucwaningo olunzulu lwezokwelapha esitshalweni ukuze kuqondwe ubuqotho benani laso lezokwelapha kangcono. Phakathi kwezinzuzo eziningi zezempilo ze-akutamma zihlanganisa;

1) Umsebenzi Wokulwa Umalaleveva

I-alkaloid esebenzayo, i-Akuammine inesibopho somsebenzi wokulwa nomalaleveva. Lokhu kwenza i-akuamma ibe ngelinye lamakhambi anamandla okulwa nomalaleveva asetshenziswa emhlabeni wonke. Izingcaphuno ezivela kumbewu ye-akutamma, amagxolo esiqu, kanye noqweqwe lwezithelo kuboniswe ukuthi kunomsebenzi ovimbelayo ngokumelene ne-Plasmodium falciparum engazweli emishanguzweni ngaleyo ndlela kusekela iqiniso lokuthi isitshalo singaba umuthi olwa nomalaleveva.

2) Umsebenzi we-Trypanocidal

Imbewu ye-Akuamma yaziwa ngokuba nomthelela wokulwa ne-parasitic kuma-parasites athile ikakhulukazi i-Trypanosoma, okuyi-protozoan eyi-parasitic ebangela ukugula okuhlukahlukene njengokugula kokulala phakathi kokunye. Ucwaningo lwesayensi luphinde lwafakazela imiphumela ye-trypanocidal yembewu ye-akuamma.

3) Umsebenzi Wokulwa Ne-Leishmanial

I-Picralima Nitida ingesinye sezitshalo okukhishwe kuzo kuye kwahlolelwa umsebenzi wokulwa ne-leishmanial kusetshenziswa i-radiorespirometric microtechnique esekwe kumshini futhi imiphumela yaqinisekisa umsebenzi omelene ne-Leishmania donovani kuma-micrograms/ml angu-50 noma ngaphansi.

4) Umsebenzi we-Antipyretic

Ngokocwaningo lokuqala lwe-pharmacological ekukhishweni kwe-methanolic kwe-akuamma, imiphumela ibonise umsebenzi we-antipyretic onamandla futhi oncike kumthamo onamaphesenti aphezulu e-Antipyrexia (38.7%) uma kuqhathaniswa naleyo ye-aspirin (29.0%). Leli xabiso lokwelapha lalesi sitshalo lithethelela ukuthi kungani lisavamile emazweni amaningi e-W. Africa.

5) Umsebenzi we-Analgesic

Ama-alkaloid akhishwe ku-akuamma akhonjiswe ukuthi anomsebenzi we-opioid analgesic. Ngokuhamba kwesikhathi, abantu baye baphendukela ekusebenziseni imbewu ye-akuamma ukuze basuse ubuhlungu obubangelwa izimo ezifana ne-migraines, i-fibromyalgia, kanye nesifo samathambo phakathi kwezinye ngempumelelo.

Kubuye kubhekwe njengenye indlela engcono kuma-opiates eza nemiphumela emibi yokuhoxa kanye nokulutheka. Imbewu yalesi sitshalo ingokwemvelo futhi inemiphumela emibi embalwa kakhulu. Ungase futhi uthathe imbewu yemisipha ebuhlungu ukuze uthole ukukhululeka kobuhlungu ngokushesha ngemva kwemizuzu eyi-15-30.

I-6) Umsebenzi Wokulwa Nokuvuvukala

Izingcaphuno ze-alkaloid ezivela ku-akuamma ziye zaphenywa ngomsebenzi wokulwa nokuvuvukala futhi imiphumela yabonisa ukuthi i-pseudo-Akuammigine inciphise kakhulu ukuvuvukala okukhulu kanye nengqikithi yokuvuvukala ngemva kokuphathwa ngomlomo kwe-alkaloid.

7) Umsebenzi Wokulwa Nohudo

Isitshalo se-Akuamma sesisetshenziswe kakhulu ngokwesiko emazweni ase-W. Afrika ukwelapha izimo eziningi zempilo ezihlanganisa isifo sohudo phakathi kwezinye izifo zesisu.

Ngokocwaningo lokunquma umsebenzi we-anti-shigellosis wokukhishwa kwe-methanol ye-akuamma ku-Shigella dysenteriae yohlobo 1 olubangelwa isifo sohudo kumagundane, kwaqashelwa ukuthi okukhishwe kwakunemiphumela elwa namagciwane ezinhlotsheni eziyishumi nanye kwezingu-17 ezihloliwe.

Ukukhishwa kwehlise ngokuphawulekayo imvamisa yokukhishwa kwendle. Kulokhu okutholakele, kusobala ukuthi okukhishwe kwe-Picralima Nitida kuyasebenza kakhulu ekuqedeni ukuphazamiseka kwamathumbu okufana nesifo sohudo.

I-8) Imisebenzi ye-Antioxidant kanye ne-Anti-Diabetic

Isifo sikashukela i-mellitus yisimo esijwayelekile se-metabolic esivame ukuhlotshaniswa nengcindezi ye-oxidative futhi ebonakala nge-hyperglycemia engapheli.

Ngokwezifundo zezokwelapha eziphenya amandla e-antioxidant kanye ne-anti-diabetes ekhishwe yi-methanol emaqabunga neziqu zesitshalo se-akuamma, kwaphawulwa ukuthi iqabunga le-methanol lekhambi libonisa umsebenzi omangalisayo we-hypoglycemia cishe ngo-38% wokunciphisa i-glycemia ngenxa ye-alkaloid. -akuammicine, okukholakala ukuthi ikhuthaza ukumuncwa kwe-glucose emangqamuzaneni, ngaleyo ndlela yehlise izinga le-glucose egazini.

Kulokhu okutholakele, kusobala ukuthi isitshalo se-akuamma sinokuzo zombili izakhiwo ze-antioxidant kanye ne-anti-diabetic ngakho-ke singasetshenziswa ekwelapheni ngempumelelo isifo sikashukela futhi sisebenze njengesisekelo lapho kungenziwa khona izidakamizwa ezintsha nezinamandla ukusiza ekwelapheni isifo sikashukela. kanye nezimo zezempilo ezihlobene.

9) Umsebenzi wokulalisa

Izinhlamvu zembewu zalesi sitshalo ziyaziwa ukunciphisa ingcindezi nokukhathazeka ukunikeza umuntu ukuzola, ukupholisa, nomphumela oqabulayo ngokuvamile. Kuphinde kukhonjiswe ukuthi kusiza ukulwa nokuhlaselwa uvalo kuyilapho futhi kucatshangelwa izinjongo zokulalisa abantu abahlangabezana nezinkinga zokulala njengokuqwasha kanye namaphupho amabi.

Imbewu inezici eziqinile zokulalisa yingakho iqinisekisa ukulala okunokuthula uma ithathwa ngaphambi nje kokulala. Kubikwa futhi ukuthi imiphumela yokupholisa yekhambi izotholwa cishe ngokushesha ikuvumela ukuthi ujabulele ukuphumula okuhle ngaphandle kobuhlungu, ukucindezeleka noma ukukhathazeka.

10) Umsebenzi Wokulwa Nezilonda

Ucwaningo oluhlola umsebenzi wokulwa nezilonda wokukhishwa kwe-methanol, izingxenyana ze-methanol kanye ne-chloroform yembewu ye-akuamma kwembula ukuthi izingxenyana nezingxenyana zekhambi zikhiqize ukwehla okuphawulekayo kwenkomba yesilonda kanye ne-acidity ephelele nomsebenzi we-pepsin.

Esikhundleni salokho, ukwanda kwepharamitha ye-Mucoprotective yasungulwa. Isici sokuvimbela izilonda zalesi sitshalo se-herbal sinezela ezinzuzweni eziningi zezempilo isitshalo esaziwa ngazo.