I-Casein phosphopeptides (CPP) iwuhlobo lwezithako zokudla ezisebenzayo
I-Casein phosphopeptide i-casein hydrolyzed nge-trypsin noma i-trypsin, ecwengwa futhi ihlanzwe. Isakhiwo sawo esiyinhloko yi-Ser (P) - Ser (P) - Ser (P) - Glu Glu - (Ser: serine, Glu: glutamic acid, P: phosphate). Izinsalela ze-phosphoserine (- Ser (P) -) kulesi sakhiwo zikhona ngamaqoqo futhi zithwala amacala amabi endaweni ebuthakathaka ye-alkaline pH yamathumbu, engavimbela ukuqhubeka kwesenzo sama-enzyme okugaya futhi kuvimbele i-CPP ekuqhubekeleni phambili kwe-hydrolysis, okuholela ekubeni khona okuzinzile. emathunjini. Ucwaningo lwasekhaya luthole ukuthi ukuncipha kwesilinganiso se-molar ye-nitrogen ku-phosphorus ku-CPP, kuba mfishane uchungechunge lwe-peptide ye-CPP, kanye nokuphakama kwamaqembu e-phosphate, okuholela ekuhlanzekeni okuphezulu kwe-CPP kanye nokukhuthazwa okunamandla kokumuncwa kwe-calcium nokusetshenziswa.
I-calcium imuncwa kalula kuphela uma ikhona isesimweni sama-ion, futhi endaweni engathathi hlangothi futhi ene-alkali ebuthaka, kulula ukwakha usawoti ongancibiliki ngama-ion e-asidi futhi ilahleke. Umphumela wokumunca we-CPP ku-calcium ubonakaliswa ngokuyinhloko ikhono layo lokuhlanganisa i-calcium endaweni engathathi hlangothi futhi ene-alkali ebuthaka, ivimbele ukukhiqizwa kwezimvula ezingancibiliki, igweme ukulahlekelwa kwe-calcium, futhi ekugcineni imunce kancane ngenxa yokwanda kokuhlushwa kwe-calcium yamahhala. Ucwaningo lwamanje lubonisa ukuthi umphumela we-CPP ekukhuthazeni ukumuncwa kwe-calcium ubonakala ngokuyinhloko kulezi zici ezilandelayo:
- (1) Khuthaza ukumuncwa kwe-calcium emathunjini amancane.
Ukudla okusanhlamvu ekudleni kwabantu kuqukethe isamba esikhulu sezakhi ze-phosphorus ezifana ne-phytic acid ne-inositol hexaphosphate, ehlangana ne-calcium endaweni ye-pH 7-8 ekugcineni okuphansi kwamathumbu amancane ukwenza i-calcium phosphate precipitates. I-CPP ingavimbela ukwakheka kwemvula ye-calcium phosphate, igcine i-calcium eningi yamahhala, ikhuthaze ukumuncwa kwe-calcium, futhi ibe enye indlela kavithamini D njengomgqugquzeli wokumuncwa kwe-calcium.
- (2) Khuthaza ukusetshenziswa kwe-calcium ngamathambo.
Ukuhlolwa kwezilwane kubonisa ukuthi i-CPP ingakhuthaza ukumuncwa kanye nokusetshenziswa kwe-calcium, yenza buthaka umphumela we-osteoclast futhi ivimbele ukubuyiswa kwamathambo.
- (3) Khuthaza ukusetshenziswa kwe-calcium ngamazinyo.
Esikhathini esidlule, kwakunenkolelo yokuthi ukuhlafuna ushizi ngemva kokudla kungashukumisa ukuphuma kwamathe, kuvumela amathe ane-alkali ukuthi avimbele izinto ezine-asidi oqweqweni lwamazinyo oqweqweni olubolayo, okusiza ukuvimbela ukuvela kwe-caries yamazinyo. Eminyakeni yamuva nje, ucwaningo luye lwathola ukuthi i-CPP equkethwe kushizi ingabopha i-calcium ions ekudleni ku-caries yamazinyo, inciphise ukuchithwa kwe-enamel, futhi ngaleyo ndlela ifinyelele imigomo ye-anti caries.
Ucwaningo luthole ukuthi isidoda endaweni yesiko equkethe i-CPP inamandla aphezulu kakhulu okungena kumaseli amaqanda futhi inganciphisa izinga lokuhlukahluka kwesidoda, okwenza ukukhula kwe-embryonic kuzinze. I-CPP ingaphinde ithuthukise i-bioavailability yama-ion ensimbi njengensimbi, i-zinc, ne-magnesium, yingakho yaziwa njengento ye-peptide enomsebenzi wokuthwala insimbi. Njengamanje, i-CPP isetshenziswe ku-curry yezingane irayisi, iziphuzo, ushingamu nokunye ukudla nemikhiqizo yezempilo phesheya. Ucwaningo kanye nokusetshenziswa kokwelashwa kokuntuleka kwe-calcium ezinganeni, i-osteoporosis kubantu asebekhulile, ukungabi nabantwana, nempilo yamazinyo nakho kuyaqhubeka. Ngenxa yokuthi i-CPP iyi-peptide ekhishwe kumaprotheni emvelo futhi inezinzuzo zokusabela okuncane okubi, ukuphepha, nokuthembeka, izosetshenziswa kabanzi. Ukusabela kokuzwela kwe-casein, amaprotheni obisi lwe-skim kanye ne-CPP kuye kwafundwa phesheya, futhi kutholakala ukuthi ukuzwela kwe-CPP kuncane kakhulu, okubonisa ukuthi kungasetshenziswa kumthethosisekelo ongazwani nobisi. Kodwa-ke, kufanele kuqashelwe ukuthi izici ezithinta umphumela we-CPP ziyinkimbinkimbi kakhulu, futhi indima yazo ku-calcium metabolism isadinga ukuthuthukiswa.
Isikhathi sokuthumela: Jun-15-2023
