Ezweni lezemithi nelokudla okunomsoco, i-Noopept ithola ukunakwa njengesithuthukisi esinamandla sokuqonda kanye ne-neuroprotectant. I-Aogubio yinkampani ehamba phambili egxile ekukhiqizeni nasekudayiseni izinto ezisebenza ekhemisi, izinto ezingavuthiwe nezikhishwe zezitshalo, okuhlanganisa i-Noopept. Isidakamizwa sokwenziwa esakhiwe inkampani yaseRussia, i-Noopept ivame ukubizwa ngokuthi i-nootropic ngenxa yezakhiwo zayo ezithuthukisa ingqondo. Kule bhulogi, sizohlola izinzuzo nokusetshenziswa kwe-Noopept, kanye nomthelela wayo ongaba khona ekusebenzeni kwengqondo kanye nempilo yonke.
Iyini i-Noopept?
I-Noopept, eyaziwa nangokuthi i-N-phenylacetyl-L-prolylglycine ethyl ester, iyinhlanganisela efundwayo ukuze ithuthukise ukusebenza kwengqondo nokulwa nokukhathazeka. Isakhiwo se-Noopept sisekelwe ku-Piracetam, enye i-nootropic eyaziwa kakhulu, ekhonjiswe ukuthi inezici ze-neuroprotective futhi ingaba nemiphumela emihle kwinkumbulo nokufunda. I-Aogubio ihamba phambili ekuhlinzekeni i-Noopept yekhwalithi ephezulu ukuze isetshenziswe ekwengezeni, ezemithi kanye nezinye izimboni.
Isebenza kanjani i-Noopept
I-Noopept iyisidakamizwa esaziwayo sokuthuthukisa ingqondo esisebenza ngokusheshisa inqubo yokwakheka kwenkumbulo nokubuyiswa. Lokhu ikwenza ngokukhuphula amazinga e-brain-derived neurotrophic factor (BDNF), inhlanganisela ekhuthaza ukukhula kwamangqamuzana obuchopho. Futhi, i-Noopept yenza i-acetylcholine (ACh) i-receptors ebuchosheni iphendule kakhudlwana ku-neurotransmitter (amakhemikhali obuchopho) i-acetylcholine, yona futhi ivumela ukudluliselwa kwemilayezo esheshayo futhi ephumelelayo phakathi kwama-neurons.
Izinzuzo Noopept
Ithuthukisa Ukusebenza Kwengqondo
Ubufakazi obuningi bomtholampilo busekela izinzuzo ze-Noopept ezindaweni ezihlukahlukene zokusebenza kwengqondo njengenkumbulo, ukufunda, nekhono lokucabanga:
- Ezigulini ezinokuphazamiseka kwengqondo okubangelwa ukuhlukumezeka noma izifo zobuchopho ze-vascular, i-Noopept ithuthukise ukusebenza kobuchopho njengoba kuboniswa ukwanda kwamandla e-alpha- kanye ne-beta-rhythms ku-electroencephalogram (EEG).
- Ukuphathwa kwe-Noopept ngesilinganiso se-20 mg nsuku zonke ngezinyanga ze-2 kuthuthukise umsebenzi wokuqonda ezigulini ezine-stroke futhi zinezinga eliphezulu lokuphepha.
- Ezinhlotsheni eziningana zezilwane zesifo i-Alzheimer (AD), i-Noopept ivikele amaseli obuchopho begundane ngokumelene nobuthi be-amyloid beta (i-causative agent ye-AD) ngokuvimbela ukulimala kwe-oxidative, ukuvimbela ukugcwala kwe-calcium, nokucindezela i-apoptosis (i-programed cell death).
- Ukulawulwa komlomo okuphindaphindiwe kwe-Noopept kumagundane kuthuthukise ukufunda uma kuqhathaniswa nomthamo owodwa.
- Kumodeli yegundane ye-stroke, i-Noopept ibonise kokubili izakhiwo zokubuyisela ukuqonda kanye ne-neuroprotective.
- Kuma-neuron obuchopho bomuntu obujwayelekile kanye ne-Down's, i-Noopept ivimbele ukulimala kwe-oxidative kanye ne-apoptosis.
- Emagundaneni aqaphelayo, ukuphathwa kwe-Noopept kwandise umsebenzi wobuchopho ku-EEG.
- I-Noopept inamandla okwandisa amazinga e-Nerve Growth Factor kanye ne-Brain Derived Neurotrophic Factor, ehlotshaniswa nokuthuthukiswa okungapheli kwenkumbulo.
- I-Noopept ingasiza ekuthuthukiseni ukusebenza kwengqondo ngokuthuthukisa amasignali kagesi phakathi kwama-neurons.
- I-Noopept ngesilinganiso esingu-1:1 noma ngokuphindwe kashumi okukhulu ibonakala inciphisa kakhulu amazinga emizimba ye-Lewy (amaqoqo amaprotheni abangela isifo sika-Parkinson) ebuchosheni.
- Emagundaneni ane-convulsive disorder, ukuphathwa okungapheli kwe-Noopept kwandise ukusebenza kahle kwe-valproate yezidakamizwa ezilwa nokuqunjelwa.
- Ucwaningo lubike ukuthi i-Noopept isebenzisa imiphumela yayo ye-neuroprotective ngokusebenzisa izakhiwo zayo ze-antioxidant ne-anti-inflammatory.
- Emagundaneni, i-Noopept ithuthukise ukudluliswa kwezimpawu zezinzwa ebuchosheni.
- Emagundaneni, i-Noopept ivimbele ngokuphelele ukuthuthukiswa kokuphazamiseka kwengqondo okubangelwa i-scopolamine.
- Emagundaneni, i-Noopept ihlehlise ukukhubazeka kwengqondo ngokwandisa amazinga e-brain-derived neurotrophic factor (BDNF).
- Kumodeli yegundane yesifo i-Alzheimer's, i-Noopept ivimbele ukuwohloka kwenkumbulo.
- Ucwaningo lubike ukuthi i-Noopept ingasiza ekuvimbeleni isifo se-Alzheimer ngokuvimbela ukwakheka kwezakhiwo zamaprotheni ezingavamile ebuchosheni nokunciphisa umsebenzi we-protein kinases (MAPK) ecushwe yi-mitogen-activated.
- Kumagundane, umjovo we-Noopept imizuzu engu-5 ngaphambi kokufunda uthuthukise inkumbulo yesikhathi eside.
- Emagundaneni ane-stroke, ukwelashwa kwe-Noopept kwehlisa indawo ye-infarction (izicubu ezifile) ebuchosheni.
- Emagundaneni, ukuphathwa kwe-Noopept ku-5 mg / kg ngemijovo kukhiqize imiphumela yokuthuthukisa ingqondo.
- Ukuphathwa kwe-0.5-10 mg / kg ye-Noopept kumagundane kukhuthaze ukufunda kweseshini eyodwa ngemva kokuphatha okukodwa, kuyilapho ukuphathwa okuphindaphindiwe kwandisa ikhono lokufunda lamagundane ahluleka ukuqeqeshwa kokuqala emsebenzini wokugwema ukugwema (ukuhlolwa okuhlola ukufunda nenkumbulo) .
- Ukuphathwa kwe-Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) kumthamo we-0.5 mg / kg imizuzu engu-15 ngaphambi kokuqala kwe-maze kaMorris kwenze ukuthuthukiswa okuphawulekayo kwinkumbulo yesikhathi eside.
- Kumagundane ane-compression-induced cerebral ischemia, ukuphathwa kwe-Noopept ngemijovo kanye nomzila womlomo kuthuthukise ukubuyiswa kwezimpendulo zokugwema okwenziwayo.
- Ucwaningo lwamaseli lwathola ukuthi i-Noopept ivimbele i-neurodegeneration eyenziwa yi-glutamate ne-oxidative stress.
- Emagundaneni ayenokukhubazeka kwengqondo ngenxa ye-lobectomy, inqubo ehilela ukususwa kwe-lobe yonke yobuchopho, i-Noopept ikhuthaze ukubuyiselwa kokufunda nenkumbulo.
- Ucwaningo lweseli lubike ukuthi i-Noopept ithuthukise ukudluliswa kwezimpawu phakathi kwamaseli obuchopho.
Ilwa Nokukhathazeka
- Amakhono okuthuthukisa ingqondo ka-Noopept nawo akhiqiza umphumela wokulwa nokukhathazeka ngokusho kwezifundo:
- Ukuphathwa kwe-Noopept ezigulini ezinokukhubazeka okuncane kwengqondo kunciphisa ukukhathala, ukukhathazeka, nokucasuka.
- Ezigulini ezinesifo sofuba sokuphefumula esisanda kutholakala, ukwelashwa kwe-Noopept kunciphise ukubonakaliswa kokukhathazeka.
- Emagundaneni, ukuphathwa kwe-Noopept kwakuhlotshaniswa nokwanda komsebenzi we-locomotor ekuhlolweni okuphakeme kwe-plus-maze, okuphakamisa umphumela wokulwa nokukhathazeka.
- Ukuphathwa kwe-Noopept kuphinde kwandise ukuziphatha kokuhlola kwamagundane ahlolwa endaweni evulekile, okubonisa ukukhathazeka okuncishisiwe.
- Kumagundane, ukuphathwa kwe-Noopept kukhiqize ukuguquguquka kwezinga lokukhathazeka.
- Emagundaneni, i-Noopept yehlisa izehlakalo zokungakwazi ukuzisiza okufundile.
- Kumagundane avela ezinhlotsheni ezihlukene, i-Noopept inciphise amazinga okucindezeleka njengoba kufakazelwa ukwanda kwenani lokusabela kokugwema ekuhlolweni kwe-slip-inducing slip-funnel test.
- Emagundane aneminyaka engu-4 izinsuku, i-Noopept iguqule izimpawu zokucindezeleka okubangelwa i-corticotropin ekhulula i-hormone (CRH).
- Ezinhlotsheni zamagundane ezifuywayo, ukuphathwa kwe-Noopept ku-1 mg ngekhilogremu nsuku zonke kwakhiqiza imiphumela yokulwa nokukhathazeka ngosuku lwe-7.
Ithuthukisa Isimo Senhliziyo
I-Noopept ingasiza futhi ukuthuthukisa isimo sengqondo, ikwenze kube yindlela yokwelapha engaba khona ezinkingeni ezithile zempilo yengqondo:
- Ukuphathwa kwe-Noopept yesikhathi eside (izinsuku ezingu-21) kuqede kakhulu ukubonakaliswa kokungabi namandla okufundiwe uma kuqhathaniswa nesidakamizwa sokulwa nokukhathazeka i-Afobazol.
- Ukuphatha okungapheli (izinsuku ezingu-28, i-0.5 mg / ngosuku ngemijovo) ye-Noopept ukuziphatha okuthuthukisiwe ngokunciphisa umsebenzi we-kinases ebangelwa ukucindezeleka (okuhileleke ekuphazamisekeni kwengqondo) nokwandisa amazinga e-BDNF.
Kafushane, i-Noopept iyinhlanganisela ethembisayo enezinzuzo ezingaba khona zomsebenzi wokuqonda, ukukhathazeka, kanye nemizwelo. I-Aogubio iwumthombo othenjwayo wekhwalithi ephezulu ye-Noopept nezinye izinto ezisebenza ngemithi, eqinisekisa ukuthi amakhasimende athola izixazululo ezinokwethenjelwa, ezisebenzayo zezidingo zabo zempilo nokuphila kahle. Kungakhathaliseki ukuthi isetshenziswa kuzithasiselo, emithini yemithi, noma kwezinye izinhlelo zokusebenza, i-Noopept inamandla okwenza umehluko onengqondo ezimpilweni zabasebenzisi. Njengoba isidingo sezithuthukisi zemvelo siqhubeka sikhula, i-AoguBio isazimisele ukuhlinzeka ngemikhiqizo emisha ukuze ihlangabezane nezidingo ezihlala zishintsha zamakhasimende ethu.
Ukubhalwa kwesihloko:Miranda Zhang
Isikhathi sokuthumela: Mar-11-2024
