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What Are The Common Cooling Agents?

2025-12-25

In the modern industry, Cooling Agents refer to a class of additives that stimulate the cold receptors (TRPM8) on the skin or mucous membranes. They produce a refreshing "cooling" sensation without physically altering the temperature of the substance itself. These agents are widely utilized in food, oral care, cosmetics, and pharmaceuticals.

Cooling agents do not function through physical heat exchange. Instead, they act as ligands that bind to the TRPM8 ion channels (the cold receptors) located at nerve endings. This binding triggers electrical signals that are sent to the brain, creating a sensory illusion of "cold" similar to coming into contact with ice.

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Core Effects of Cooling Agents

  • Cool feeling

Cooling Agents can produce a cooling sensation on the skin or mouth, providing a comfortable use experience, especially when used in hot weather or after exercise, and can bring a sense of relaxation.

  • Soothing effect

Many coolants have a soothing and calming effect that can relieve skin irritation, redness and discomfort and are suitable for use on sensitive skin.

  • Antibacterial Properties

Some coolants, such as menthol and camphor, have antibacterial properties that can help inhibit bacterial growth and improve skin and oral health.

  • Improve product experience

Adding coolants to skin care and cosmetic products can enhance the sensory experience of the product, making users feel fresh and comfortable.

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Menthol

  • Product Characteristics

 High Explosive Impact: Capable of generating an instant and powerful cooling surge; it is the fastest-acting cooling agent available.

 Distinct Aroma: Features a rich, potent minty fragrance that is highly recognizable.

 Limitations: Highly volatile with a short duration (10–15 minutes). At high concentrations, it produces a sharp stinging/burning sensation and a bitter taste. Its strong scent can easily overpower the product's original flavor.

  • Applications

Primarily used in toothpaste, medicated oils, and mint candies where a minty scent is a requirement.

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    WS-23 (Front-mouth Cooling)

    • Product Characteristics

     Flavor Neutral: Almost odorless and tasteless; it does not interfere with the product’s intended aroma or flavor profile.

     Sensation Area: The cooling effect is primarily concentrated on the front of the mouth, the tongue surface, and the upper palate.

     Heat Stability: Features excellent stability and can withstand high-temperature processing (above 200°C).

    • Applications

    Widely used in E-liquids, various beverages, chewing gums, gummies, and food products requiring a "pure cold sensation."

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      WS-5 (Extreme Intensity)

        • Product Characteristics

         Ultra Intensity: Its cooling intensity is approximately 3 to 4 times that of menthol, making it one of the strongest synthetic cooling agents known.

         Cooling Quality: Provides an extremely pure and deep cold sensation without the stinging or irritating "punch" associated with menthol.

        • Applications

        Products requiring an "extreme ice" physical experience, such as extra-strong throat lozenges, high-end liquid-core (pop-bead) candies, and specific medicinal sprays.

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          WS-12 (Ultra-long Persistence)

          • Product Characteristics

           Ultra-long Persistence: The cooling duration is exceptionally long—often several times that of menthol—with a steady and smooth release.

           Excellent Safety: Extremely low irritation to the skin and mucous membranes; it does not cause numbness or burning.

           Sensation Area: The sensation extends primarily to the root of the tongue and the throat.

          • Applications

          Used in long-acting mouthwashes, toothpastes, high-performance skincare (e.g., after-sun repair), and luxury cosmetics..

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            WS-3

            WS-3 is one of the most classic and long-standing cooling agents in the WS series, often serving as the benchmark for measuring the performance of other synthetic cooling agents.

            • Product Characteristics

             Sensation Area: The cooling effect primarily impacts the back of the mouth, the throat, and the root of the tongue.

             Longevity: It is significantly more persistent than menthol, typically maintaining a cooling sensation for 20 to 30 minutes.

             Flavor Profile: Although it is a derivative of menthol, it has almost none of the sharp, medicinal, or spicy notes of mint, causing minimal impact on the product's original flavor.

             Stability: It possesses excellent thermal stability and does not degrade under standard processing temperatures.

            • Applications

             Oral Care: Mouthwashes and toothpastes (providing long-lasting freshness).

             Confectionery: Chewing gums, chocolates, and hard candies.

             Pharmaceuticals: Throat lozenges or sprays used to relieve throat discomfort.

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            WS-27

            WS-27 is a relatively newer and well-balanced cooling agent, often regarded as an enhanced version of WS-23.

            • Product Characteristics

             Cooling Experience: The sensation is exceptionally pure and gentle, without significant stinging or burning sensations.

             Sensation Area: Similar to WS-23, it mainly acts on the front of the mouth, the tongue surface, and the upper palate, but the overall physical sensation is more "three-dimensional" than WS-23.

             High Solubility: Compared to WS-3, WS-27 has better solubility in water and certain solvents, making it easier to incorporate into formulations.

             Odorless and Tasteless: It is almost entirely odorless and tasteless, ensuring it does not interfere with the high-end aromas of food or cosmetics.

            • Applications

             Premium Beverages: Sparkling waters and functional drinks (providing a clean cold sensation).

             Cosmetics: Soothing sprays and eye care products (due to its extreme mildness).

             Innovative Foods: Frozen desserts and high-end liquid-core (pop-bead) candies.

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            Camphor

            Camphor is a bicyclic ketone compound naturally found in camphor trees or produced synthetically.

            • Product Characteristics

             Dual Sensory Experience: It creates a cooling sensation at low concentrations. At higher concentrations or with repeated application, it can produce a warming sensation or even a slight numbing effect.

             Strong Odor: It possesses a highly recognizable, pungent, and penetrating scent.

             Pharmacological Activity: It has mild antipruritic (anti-itch), analgesic (pain-relieving), and antibacterial properties.

            • Applications

            It is widely used in medicinal products like anti-itch creams and muscle ache ointments (e.g., Tiger Balm). It is also found in oil-control conditioners for men, though it is rarely used in facial skincare due to its heavy scent.

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            Menthyl Lactate

            • Product Characteristics

             Mild & Gentle: Provides a soft cooling sensation with a slow-release mechanism, completely lacking the harsh "head-rush" of menthol.

             Skin-Friendly: Highly compatible with the skin; it is one of the least irritating menthol derivatives.

             Faint Odor: Carries a very weak minty scent, ensuring it does not interfere with delicate fragrance formulations.

            • Applications

            Extensively used in personal care products, such as skincare lotions, shaving creams, shower gels, and sunscreens.

            Eucalyptol

            • Product Characteristics

             Refreshing and Breathable: It provides a sensation of "opening the airways," accompanied by a strong herbal and camphoraceous aroma.

             Multifunctional: It possesses significant anti-inflammatory, expectorant, and antiseptic properties.

            • Applications

            It is a core ingredient in mouthwashes (like Listerine) for sterilization and long-lasting freshness. It is also used in throat lozenges, inhalants, and ointments for nasal congestion.

            Comparison of Common Cooling Agents

            Name

            Type

            Intensity (vs. Menthol)

            Duration

            Primary Sensation Area

            Flavor & Odor Profile

            Main Applications

            Menthol

            Natural/ Synthetic

            100 (Baseline)

            Short (10-15m)

            Full Mouth / Skin

            Strong minty aroma; pungent/burning at high doses

            Toothpaste, medicated balms, mints

            WS-23

            Synthetic

            75

            Medium

            Front mouth, Tongue

            Nearly odorless and tasteless

            E-liquids, beverages, gummies

            WS-5

            Synthetic

            350 - 400

            Long

            Throat, Upper palate

            Extremely faint odor; pure and deep cold

            Power lozenges, premium pop-beads

            WS-12

            Synthetic

            200

            Ultra-Long

            Throat, Tongue root, Skin

            Tasteless; very low irritation; very gentle

            Long-acting mouthwash, luxury skincare

            WS-3

            Synthetic

            150

            Long (20-30m)

            Back mouth, Throat

            Very faint minty note; crisp freshness

            Oral care, chewing gum, pharma

            WS-27

            Synthetic

            120

            Medium-Long

            Front mouth, Palate

            Odorless and tasteless; smooth/3D feel

            Premium drinks, mild skincare

            Menthyl Lactate

            Ester Derivative

            Low

            Fairly Long

            Skin, Mucosa

            Almost odorless; gentle with no "hit"

            Sunscreens, lotions, shaving cream

            Camphor

            Natural/ Synthetic

            Low/Medium

            Medium

            Skin, Respiratory tract

            Strong medicinal scent; dual cool/warm feel

            Anti-itch creams, muscle rubs

            Eucalyptol

            Natural Extract

            Medium

            Short-Medium

            Respiratory tract, Nasal

            Strong herbal/woody; "breathable" feel

            Mouthwash, lozenges, nasal balms

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            Key Insights & Selection Guide

            • Ranking by Intensity

             Extreme Intensity: WS-5 > WS-12 > WS-3.

             Moderate Intensity: WS-27 > Menthol > WS-23.

             Mild/Functional: Menthyl Lactate, Eucalyptol, Camphor.

            • Selection Based on Requirements

             Zero Flavor Interference: If you want a cold sensation without changing the taste of food or the scent of perfume, choose WS-23 or WS-27.

             Maximum Duration: For effects that need to last through eating or drinking, choose WS-12 or WS-3.

             Instant "Wow" Factor: If you need an immediate blast of cold upon application, Menthol is essential.

             Sensitive Skin or Eye Area: The safest choice is Menthyl Lactate due to its low irritation profile.

             Medicinal/Muscle Relief: Use Camphor or Eucalyptol combined with Menthol for their analgesic and soothing properties.

            • Popular "Golden" Compounding Strategies

             Full Oral Coverage: Blend WS-23 (front-mouth) with WS-3 (back-mouth) to eliminate "dead zones."

             The "Ice-Cold" Beverage: Combine WS-23 (as the base) with a trace amount of WS-5 for an intense, premium chill.

             Sophisticated Skincare Cooling: Use Menthyl Lactate (as a gentle base) with WS-12 (to maintain the feeling for hours).

             

            • Name: Daisy Jia
            • Email: imaherb@aogubio.com
            • WhatsApp: +86-18149253521