N-acetylneuraminic aside , izwi kandi nka acide sialic, ni molekile isanzwe ya karubone ya hydrata iboneka muri sisitemu zitandukanye. Ifite uruhare runini mumikorere ya selire kandi ifite porogaramu nyinshi mubice bitandukanye.
Acide ya Sialic ni aside isukari icyenda ya karubone kandi ikomoka kuri aside ya neuraminike. Ubusanzwe iboneka kumpera yinyuma ya glycans (iminyururu ya oligosaccharide) ifatanye na proteyine cyangwa lipide hejuru ya selile. Iyi glycans, izwi kandi nka glycans ya sialylated, igira uruhare mubikorwa byingenzi bya selile nko kumenyekanisha ingirabuzimafatizo, ibimenyetso, hamwe no gukingira indwara.
Nibihe Bikorwa byaN-acetylneuraminic Acide?
- Kumenyekanisha Akagari: Sialic aside irimo glycans ikora nkibimenyetso byerekana hejuru ya selile. Bagira uruhare mubikorwa bitandukanye nko gufatira ingirabuzimafatizo, kumenyekanisha ingirabuzimafatizo, no gutandukana.
- Immune Igisubizo: Acide Sialic igira uruhare runini muguhindura ubudahangarwa bw'umubiri. Irashobora gukora nk'iyakirwa rya virusi, ifasha gutangiza ubudahangarwa bw'umubiri urwanya mikorobe. Byongeye kandi, guhindura aside sialic kuri antibodies bigira uruhare mubikorwa byayo mukurinda indwara.
- Ibimenyetso bya selile:Acide Sialic irashobora kugira uruhare mukumenyesha inzira ya selile no kugenzura inzira zingenzi za selile nko gukwirakwiza selile, gutandukanya, na apoptose.
- Kurinda no Gusiga: Acide Sialic ifasha kurinda selile ibintu byangiza mukubera inzitizi yumubiri. Iragira kandi uruhare mu gusiga amavuta ya mucosal, nk'ayari mu myanya y'ubuhumekero na gastrointestinal.
Ni ubuhe buryo bukoreshwaN-acetylneuraminic Acide?
- Inganda zimiti: Sialic aside ishingiye kubintu bifite imiti. Kurugero, ibikomoka kuri acide sialic byakorewe ubushakashatsi kubintu bya virusi kandi nkibishobora kwanduza virusi. Byongeye kandi, inhibitori ya sialidase, ibuza kuvanaho ibisigazwa bya aside ya sialic muri glycans, birakorwaho iperereza kubyo bashobora kuvura.
- Ubushakashatsi bwa Glycobiology: Acide ya Sialic na glycans ya sialylated yizwe cyane mubijyanye na glycobiology. Isesengura ryabo rirashobora gutanga ubushishozi muburyo bwindwara, imikorere ya selile, no kuvumbura biomarker.
- Ibikoresho byo gusuzuma: Urwego rwa acide ya Sialic, guhindura, no guhindura bikoreshwa nka biomarkers mu ndwara zitandukanye nka kanseri, indwara z'umutima n'imitsi, hamwe n'indwara zishingiye ku ngirabuzima fatizo. Kumenya no gusesengura aside sialic irashobora gutanga amakuru yingirakamaro yo gusuzuma.
- Inganda n'ibiribwa: Acide Sialic iboneka mubiribwa bimwe na bimwe, nk'amata n'amagi. Rimwe na rimwe byongerwa kumata nkinyongera yintungamubiri kubana batonsa.
Kwandika ingingo: Coco Zhang
Igihe cyo kohereza: Mutarama-12-2024
