Chii chinonzi Adenosine?

Adenosine inonzi nucleoside inowanzoitika mumasero ese emuviri. Kemikari ndeye 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Chimiro uye mazinga eropa

Adenosine inoumbwa neadenine yakasungirirwa kune ribose shuga molecule (ribofuranose) moiety. Chisungo chinonamatira adenine uye shuga yeribose inonzi β-N9-glycosidic bond.

Yakajairika plasma adenosine level iri pakati pe0.04 ne0.2 micromoles.

Physiological uye pharmacological basa reAdenosine

Mumuviri, adenosine inobatsira mukufambiswa kwesimba remagetsi nekugadzira mamorekuru seadenosine triphosphate (ATP) uye adenosine diphosphate (ADP).

Adenosine inoitawo basa mukusaina nzira dzakasiyana siyana uye mabasa mumuviri nekugadzira zvine mutsindo mamorekuru senge cyclic adenosine monophosphate (cAMP).

Adenosine muuropi

Muuropi adenosine inhibitory neurotransmitter. Izvi zvinoreva, adenosine inogona kuita sepakati tsinga inodzvinyirira. Mumamiriro ezvinhu akajairika, inokurudzira kurara uye inodzvinyirira kumuka. Kana ukamuka mazinga eadenosine muuropi anokwira awa imwe neimwe.

Adenosine mumoyo

Mumoyo adenosine inokonzeresa kuwanda kwetsinga dzeropa dzinovandudza kutenderera kweropa kumoyo. Adenosine inowedzerawo dhayamita yetsinga dzeropa munhengo dzepedyo.

Mumoyo adenosine inoderedza kurova kwemoyo uye muropa ine anti-platelet action. Antiplatelet chiito chinodzivirira kuunganidzwa kweplatelet uye coagulation.

Adenosine muropa

Muropa adenosine inoputsika neadenosine deaminase. Iyi enzyme iripo mumasero matsvuku uye madziro emidziyo. Mushonga Dipyridamole inhibitor ye enzyme adenosine deaminase uye nokudaro inosimudza mazinga eadenosine muropa. Izvi zvinotungamirira kukudziridzika kwetsinga yeropa uye nekunatsiridza kuyerera kweropa kuburikidza netsinga dzeropa dzinopa tsandanyama dzemoyo.

Adenosine muitsvo, mapapu uye chiropa

Muitsvo adenosine inoderedza kuyerera kweropa renal uye kuderedza kugadzirwa kwe rennin kubva muitsvo.

Mumapapu inokonzeresa kutsikirira kwenzira dzemhepo uye muchiropa zvinotungamira mukutsikirira kwetsinga uye inowedzera kuparara kweglycogen kuita glucose.

Adenosine inhengo inongoitika yechisikigo inoita basa rakakosha mune akasiyana maitiro emuviri mumuviri wemunhu. Iyo nucleoside, zvinoreva kuti inoumbwa neadenine molecule yakabatana ne ribose molecule. Adenosine inowanikwa mumaseru ese uye inobatanidzwa mukufambiswa kwesimba sechikamu cheadenosine triphosphate (ATP), iyo sero yekutanga simba mari. Pamusoro pebasa rayo musimba remetabolism, adenosine inoshandawo senge rekusaina molecule, ichiita kuburikidza nema receptors chaiwo mumuviri.

Chimwe chezvinhu zvakakosha zveadenosine pharmacology ndiyo nzira yayo yekuita. Adenosine inoshanda nekusunga kune chaiwo adenosine receptors, ayo ane mana madiki: A1, A2A, A2B, uye A3. Imwe neimwe isoform inosanganiswa neakasiyana physiological mabasa uye masaini nzira. Kana adenosine inosunga kune mareceptors ayo, inogadzirisa zvakasiyana-siyana zvemaserura maitiro, kusanganisira neurotransmission, vascular tone, uye immune function. Semuenzaniso, kushandiswa kweA1 receptors kunogona kutungamirira kukudzivirira kwekusunungurwa kweurotransmitter, asi kushandiswa kweA2A receptors kunogona kutungamirira ku vasodilation uye anti-inflammatory effects.

Kunzwisisa iyo pharmacology yeadenosine inotungamira kumakiriniki mashandisirwo mune akasiyana ekurapa marongero. Imwe yeanonyanya kuzivikanwa makiriniki anoshandisa adenosine ibasa rayo mukurapa kweimwe cardiac arrhythmias. Adenosine inoshandiswa seantiarrhythmic agent nekuda kwekugona kwayo kunonoka conduction kuburikidza neatrioventricular node, nekudaro ichikanganisa nzira yekudzoka uye kudzorera yakajairika sinus rhythm. Pamusoro pezvo, adenosine inoshandiswa semushonga wekushushikana mupfungwa muzvidzidzo zvekufungidzira zvemoyo kuti uongorore myocardial perfusion.

Muchidimbu, adenosine imorekuru rakawanda rine mashandisirwo mazhinji ekiriniki nekuda kweiyo pharmacological zvimiro uye maitiro ekuita. Kugona kwayo kugadzirisa masero emagetsi kuburikidza nekusangana kwakasiyana kwekugamuchira kunoita kuti ive chishandiso chakakosha mukurapa dzakasiyana siyana dzehutano, kubva kumoyo arrhythmias kusvika kuzvirwere zvekufema pamwe nekugona neuroprotective application. Sezvo tsvakiridzo yeadenosine ichienderera mberi, kushandiswa kwekiriniki kutsva kweiyi morekuru inonakidza inogona kuramba ichibuda, ichiwedzera kuwedzera kugona kwayo kwekurapa mukurapa.

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