I-10 yeeNzuzo zeMpilo ezimangalisayo ze-Akuamma

I-Akuamma, ngenye indlela eyaziwa ngokuba yi-Picralima Nitida, ivela kwisihlahla esifana nomthi (ubude obufana nezityalo ze-Kratom) ezichumayo ecaleni komlambo eNtshona Afrika. Iialkaloids eziphambili ezikhoyo kwimbewu ye-Akuamma yi-Akuammine kunye ne-Pericine - zombini zithelekiseka neMitragynine eKratom.

Ngenxa yokuba i-Akuamma ifana ngeendlela ezininzi - iziphumo zokuthatha i-Akuamma Seed nazo zifana kakhulu nokutya amagqabi eKratom.

I-alkaloids eziphambili ezenza isityalo sibe namandla kwaye siphumelele ziquka;

• I-Akuammidine- le yeyona alkaloid yembewu kwaye isebenza ngokuphembelela iindawo zokubopha i-opioid. I-alkaloid ibonelela ngeempawu ze-analgesic ukunceda ekupheliseni iintlungu kunye nokusebenza njengento yokuphumza izihlunu.
• I-Akuammine- le alkaloid inobudlelwane obuphezulu beendawo zokubopha i-mu-opioid, ngokungafaniyo ne-Akuammidine. Inceda ngokubonelela ngeempembelelo ze-analgesic, nangona kunjalo, inokubangela impembelelo yokuthintela kwintshukumo ye-peristaltic yamathumbu ukuba isetyenziswe kwiidosi eziphezulu.
• Akuammicine- le alkaloid, kwelinye icala, inobudlelwane obuphezulu beendawo zokubopha i-kappa-opioid.
• I-Pseudo-Akuammigine- le alkaloid ibonelela ngeziphumo ezichasayo kunye ne-analgesic. Ngokuxhomekeke kwidosi, i-alkaloid iyavuyisa, imodareyitha ukunyanzeliswa kwemisipha ye-skeletal, i-contraction ye-muscle egudileyo, inkqubo ye-nervous central, kunye nokuphefumla.
• I-Akuammigine- le ibonise kuphela ukuba ine-anti-adrenergic effect kwimithambo yegazi kunye nentliziyo.
• I-Pericine- le ibonakaliswe ukuba ibophelele kwi-opioid receptors, nangona kunjalo, inokubangela ukuxhuzula okukhokelela ekucuthekeni okuzenzekelayo kwemisipha.

I-Akuamma namhlanje ithathwa njengenye indlela ebhetele kwezinye izinto ezirhabaxa njengoko iqinisekisa ukuthomalaliswa kweentlungu ngokupheleleyo. Oku kuye kwabangela ukuba uphando olubanzi lwezonyango kwisityalo siqonde imfezeko yexabiso laso lonyango ngcono. Phakathi kweenzuzo ezininzi zempilo ze-akutamma ziquka;

1) Umsebenzi ochasene neMalariya

I-alkaloid esebenzayo, i-Akuammine inoxanduva lomsebenzi wokulwa nemalariya. Oku kwenza i-akuamma ibe yenye yezona zityalo zinamandla zokulwa nemalariya ezisetyenziswa kwihlabathi liphela. Izicatshulwa ezivela kwimbewu ye-akuamma, i-stem bark, kunye ne-fruit rind zibonakaliswe ukuba zinomsebenzi othintelayo kwi-Plasmodium falciparum enganyangekiyo ngamachiza ngaloo ndlela ixhasa inyaniso yokuba imifuno lichiza elinokubakho lokulwa nemalariya.

2) Umsebenzi weTrypanocidal

Imbewu ye-Akuamma iyaziwa ngokuba nefuthe elichasayo kwi-parasites ngokukodwa i-Trypanosoma, eyi-protozoan ye-parasitic ebangela izigulo ezahlukeneyo ezifana nokugula kokulala phakathi kwabanye. Izifundo zobuNzululwazi nazo zibonakalise iziphumo ze-trypanocidal zembewu ye-akuamma.

3) Umsebenzi ochasene neLeishmanial

I-Picralima Nitida yenye yezityalo ezinezicatshulwa eziye zavavanywa kumsebenzi wokulwa ne-leishmanial usebenzisa i-microtechnique esekelwe kwi-radiorespiramometric microtechnique kunye neziphumo eziqinisekisiweyo ezichasene ne-Leishmania donovani kwi-50 okanye ngaphantsi kwe-micrograms / ml.

4) Umsebenzi we-Antipyretic

Ngokophononongo lwangaphambili lwe-pharmacological kwisicatshulwa se-methanolic ye-akuamma, iziphumo zibonise umsebenzi onamandla kunye nokuxhomekeka kwidosi ye-antipyretic enepesenti ephezulu ye-Antipyrexia (38.7%) xa kuthelekiswa naleyo ye-aspirin (29.0%). Eli xabiso leyeza leyeza lithethelela isizathu sokuba lisaxhaphakile kumazwe amaninzi ase-W. Afrika.

5) Umsebenzi we-Analgesic

I-alkaloids ekhutshwe kwi-akuamma iboniswe ukuba inomsebenzi we-opioid analgesic. Ngokuhamba kwexesha, abantu baye bajika basebenzise imbewu ye-akuamma ukukhupha iintlungu ezibangelwa ziimeko ezinjenge-migraines, i-fibromyalgia, kunye nesifo samathambo phakathi kwabanye ngempumelelo.

Ikwathathwa njengenye indlela engcono kwii-opiates eziza neziphumo ebezingalindelekanga zokurhoxa kunye nokulutha. Imbewu yesi sityalo iyindalo kuphela kwaye ineziphumo ebezingalindelekanga ezimbalwa kakhulu. Usenokuthatha imbewu yezihlunu ezibuhlungu ukuze ufumane isiqabu kwangoko emva kwemizuzu eyi-15-30.

I-6) Umsebenzi ochasene nokuvuvukala

Izicatshulwa ze-alkaloid ezivela kwi-akuamma ziye zaphandwa umsebenzi wokuchasana nokudumba kwaye iziphumo zibonise ukuba i-pseudo-Akuammigine yanciphisa kakhulu i-maximal maximal kunye nokudumba okupheleleyo emva kokulawulwa komlomo kwe-alkaloid.

7) Umsebenzi ochasayo wotyatyazo

Isityalo sase-Akuamma sisetyenziswe ngokubanzi ngokwesiko kumazwe ase-W. Afrika ukunyanga iimeko ezininzi zempilo kuquka isifo segazi phakathi kwezinye izifo zesisu.

Ngokophononongo lokumisela umsebenzi we-anti-shigellosis wesicatshulwa se-methanol ye-akuamma kwi-Shigella dysenteriae uhlobo lwe-1 olubangela urhudo kwiimpuku, kwaphawulwa ukuba isicatshulwa sineempembelelo ze-antimicrobial kwishumi elinanye kwi-pathogenic strains evavanyiweyo.

Isicatshulwa sinciphise ngokuphawulekayo ukuphindaphinda kwelindle elikhutshwayo. Ukusuka kwezi ziphumo, kuyacaca ukuba i-Picralima Nitida extracts iyasebenza kakhulu ekupheliseni ukuphazamiseka kwesisu esifana nesifo sohudo.

8) Imisebenzi ye-Antioxidant kunye ne-Anti-Diabetic

Isifo seswekile iMellitus yimeko yemetabolism eqhelekileyo edla ngokunxulunyaniswa noxinzelelo lweoxidative kwaye ibonakaliswa yi-hyperglycemia engapheliyo.

Ngokwezifundo zonyango eziphanda nge-antioxidant kunye ne-ant-diabetes enokubakho kwincindi ye-methanol yamagqabi kunye neziqu zesityalo se-akuamma, kwafunyaniswa ukuba isicatshulwa segqabi se-methanol somthi sibonise umsebenzi omangalisayo we-hypoglycemia kunye ne-38% yokunciphisa i-glycemia ngenxa ye-alkaloid. -akuammicine, ekholelwa ukuba ikhuthaza ukunyuswa kwe-glucose kwiiseli, ngaloo ndlela inciphisa izinga le-glucose egazini.

Kolu phando, kuyabonakala ukuba isityalo i-akuamma sinazo zombini iipropathi ze-antioxidant kunye ne-anti-diabetes kungoko zingasetyenziselwa ukunyanga isifo seswekile kwaye zisebenze njengesiseko apho amachiza amatsha nanamandla anokuphuhliswa ukunceda kunyango lwesifo seswekile. kunye neemeko zempilo ezinxulumeneyo.

9) Umsebenzi wokuthomalalisa

Izicatshulwa zembewu zalo myeza ziyaziwa ukunciphisa uxinzelelo kunye noxinzelelo ukunika umntu ukuzola, ukuthomalalisa, kunye nesiphumo sokuphumla ngokubanzi. Ikwabonisiwe ukunceda ukulwa nohlaselo loloyiko ngelixa ikwaqwalaselwa ngenjongo yokuthomalalisa ngabantu abaneengxaki zokulala ezifana nokuphuthelwa kunye namaphupha amabi.

Imbewu ineempawu ezinamandla zokuthomalalisa kungoko iqinisekisa obona buthongo bunoxolo ukuba ithathwe kanye phambi kokulala. Kukwaxelwa ukuba iziphumo zokuthomalalisa imifuno ziya kufunyanwa ngokukhawuleza zikuvumela ukuba ukonwabele ukuphumla okuhle ngaphandle kweentlungu, uxinzelelo okanye ixhala.

10) Umsebenzi wokulwa neSilonda

Uphononongo oluvavanya umsebenzi wokuchasana nesilonda sesicatshulwa semethanol, amaqhezu e-methanol kunye nekloroform yembewu ye-akuamma lubonise ukuba amaqhezu kunye nezicatshulwa zemifuno zivelise ukuncipha okuphawulekayo kwisalathisi sesilonda kunye ne-asidi epheleleyo kunye nomsebenzi we-pepsin.

Kunoko, ukunyuka kweparameter ye-Mucoprotective yasungulwa. Ipropathi yokuthintela isilonda yesi sityalo semifuno yongeza kwiinzuzo ezininzi zempilo isityalo esaziwa ngaso.