Kwihlabathi lamachiza kunye ne-nutraceutical, i-Noopept ifumana ingqwalasela njengento enokubakho yokuphucula ingqondo kunye ne-neuroprotectant. I-Aogubio yinkampani ehamba phambili ejongene nemveliso kunye nokuthengiswa kwezinto ezisebenzayo ze-pharmacologically, izinto eziluhlaza kunye nezityalo zezityalo, kuquka i-Noopept. Ichiza elenziwe yinkampani yaseRashiya, i-Noopept idla ngokubizwa ngokuba yi-nootropic ngenxa yezinto ezinokubakho zokuphucula ingqondo. Kule bhlog, siza kuphonononga izibonelelo kunye nokusetyenziswa kweNoopept, kunye nefuthe elinokubakho ekusebenzeni kwengqondo kunye nempilo iyonke.
Yintoni iNoopept?
I-Noopept, eyaziwa ngokuba yi-N-phenylacetyl-L-prolylglycine ethyl ester, i-compound efundwayo ukuze ikwazi ukuphucula umsebenzi wokuqonda kunye nokulwa nokuxhalaba. Isakhiwo se-Noopept sisekelwe kwiPiracetam, enye i-nootropic eyaziwayo, ebonakaliswe ukuba ineempawu ze-neuroprotective kwaye ingaba nemiphumo emihle kwimemori nokufunda. I-Aogubio ihamba phambili ekuboneleleni nge-Noopept ephezulu yokusetyenziswa kwi-supplement, amayeza kunye namanye amashishini.
Isebenza njani iNoopept
I-Noopept yinto eyaziwayo yokuphucula i-cognitive-enhance drug esebenza ngokukhawulezisa inkqubo yokubunjwa kwememori kunye nokubuyiswa. Ikwenza oku ngokunyusa amanqanaba e-brain-derived neurotrophic factor (BDNF), ikhompawundi ekhuthaza ukukhula kweeseli zengqondo. Kwakhona, i-Noopept yenza i-acetylcholine (ACh) i-receptors kwingqondo iphendule ngakumbi kwi-neurotransmitter (ikhemikhali yengqondo) i-acetylcholine, leyo ivumela ukuthunyelwa ngokukhawuleza kunye nokusebenza kakuhle kwemiyalezo phakathi kwe-neurons.
Iinzuzo zeNoopept
Ukuphucula ukusebenza kwengqondo
Ubungqina obuninzi beklinikhi buxhasa izibonelelo zeNoopept kwiindawo ezahlukeneyo zomsebenzi wokuqonda njengememori, ukufunda, kunye nokukwazi ukucinga:
- Kwizigulane ezinokuphazamiseka kwengqondo okubangelwa yi-traumas okanye izifo ze-vascular brain, i-Noopept iphucule ukusebenza kwengqondo njengoko kubonakaliswe ngokunyuka kwe-alpha- kunye ne-beta-rhythms amandla kwi-electroencephalogram (EEG).
- Ulawulo lwe-Noopept kwi-dose ye-20 mg imihla ngemihla kwiinyanga ze-2 ziphuculwe umsebenzi wokuqonda kwizigulane ezine-stroke kwaye zinezinga eliphezulu lokhuseleko.
- Kwiimodeli ezininzi zezilwanyana zesifo se-Alzheimer (AD), i-Noopept ikhusele iiseli zengqondo yegundane ngokuchasene ne-amyloid beta toxicity (i-causative agent ye-AD) ngokuthintela umonakalo we-oxidative, ukuthintela ukugqithiswa kwe-calcium, kunye nokucinezela i-apoptosis (ukufa kweseli ecwangcisiweyo).
- Ukulawulwa komlomo okuphindaphindiweyo kwe-Noopept kwiigundane kuphuculwe ukufunda xa kuthelekiswa nedosi enye.
- Kwimodeli yegundane ye-stroke, i-Noopept ibonise zombini i-cognition-restoring and neuroprotective properties.
- Kwisiqhelo kunye ne-Down's syndrome ii-neuron zobuchopho bomntu, i-Noopept ithintele ukonakala kwe-oxidative kunye ne-apoptosis.
- Kwiigundane eziqaphelayo, ulawulo lwe-Noopept lwandise umsebenzi wobuchopho kwi-EEG.
- I-Noopept inamandla okunyusa amanqanaba e-Nerve Growth Factor kunye ne-Brain Derived Neurotrophic Factor, ehambelana nokuphuculwa okungapheliyo kwimemori.
- I-Noopept inokunceda ukuphucula umsebenzi wokuqonda ngokuphucula imiqondiso yombane phakathi kwe-neurons.
- I-Noopept kwi-1: umlinganiselo we-1 okanye uphindwe kalishumi ubonakale ukunciphisa kakhulu amanqanaba emizimba ye-Lewy (i-protein clumps ebangela isifo sika-Parkinson) kwingqondo.
- Kwiimpuku ezinengxaki yokuxhuzula, ulawulo olungapheliyo lwe-Noopept lwandise ukusebenza kwe-anticonvulsant drug valproate.
- Uphononongo luchaze ukuba i-Noopept isebenzisa iziphumo zayo ze-neuroprotective ngokusebenzisa i-antioxidant kunye ne-anti-inflammatory properties.
- Kwiigundane, i-Noopept yandisa ukuhanjiswa kwemiqondiso ye-nerve kwingqondo.
- Kwiimpuku, i-Noopept ithintele ngokupheleleyo ukuphuhliswa kokuphazamiseka kwengqondo okubangelwa yi-scopolamine.
- Kwiigundane, i-Noopept iguqule ukukhubazeka kwengqondo ngokunyusa amanqanaba e-brain-derived neurotrophic factor (BDNF).
- Kwimodeli yegundane yesifo se-Alzheimer, i-Noopept ithintele ukuwohloka kwememori.
- Uphononongo luchaze ukuba i-Noopept inokunceda ukukhusela isifo se-Alzheimer ngokuthintela ukubunjwa kwezakhiwo zeprotheyini ezingaqhelekanga kwingqondo kunye nokunciphisa umsebenzi wokuxinzezeleka kwe-mitogen-activated protein kinases (MAPK).
- Kwiimpuku, inaliti ye-Noopept imizuzu emi-5 ngaphambi kokuba kufundwe kuphuculwe inkumbulo yexesha elide.
- Kwiigundane ezine-stroke, unyango lwe-Noopept lunciphise indawo ye-infarction (izicubu ezifileyo) kwingqondo.
- Kwiigundane, ulawulo lwe-Noopept kwi-5 mg / kg ngee-injection eziveliswe iziphumo zokuphucula ingqondo.
- Ukulawulwa kwe-0.5-10 mg / kg ye-Noopept kwiigundane kukhuthaze ukufunda kweseshoni enye emva kokulawula okukodwa, ngelixa ulawulo oluphindaphindiweyo lwandisa amandla okufunda amagundane ahlulekayo ukuqeqeshwa kokuqala kumsebenzi wokuphepha (uvavanyo oluvavanya ukufunda kunye nememori) .
- I-Noopept (GVS-111, i-N-phenylacetyl-L-prolylglycine ethyl ester) yolawulo kwi-dose ye-0.5 mg / kg imizuzu eyi-15 ngaphambi kokuqala kwe-maze ye-Morris yenza ukuphuculwa okubalulekileyo kwimemori yexesha elide.
- Kwiigundane ezine-compression-induced cerebral ischemia, ulawulo lwe-Noopept ngeenaliti kunye nomzila womlomo uphuculwe ukubuyiswa kweempendulo zokuphepha.
- Uphononongo lweeseli lufumene ukuba i-Noopept ithintele i-neurodegeneration eyenziwa yi-glutamate kunye noxinzelelo lwe-oxidative.
- Kwiigundane ezinokukhubazeka kwengqondo ngenxa ye-lobectomy, inkqubo ebandakanya ukususwa kwe-lobe yonke yengqondo, i-Noopept yakhuthaza ukubuyiselwa kokufunda kunye nememori.
- Uphononongo lweseli luxele ukuba i-Noopept iphucule ukuhanjiswa kwemiqondiso phakathi kweeseli zengqondo.
Ulwa nexhala
- Izakhono zokuphucula ingqondo kaNoopept nazo zivelisa umphumo wokuchasana nokuxhalaba ngokwezifundo:
- Ulawulo lwe-Noopept kwizigulana ezinokuphazamiseka kwengqondo kancinci kunciphisa ukudinwa, ukuxhalaba, kunye nokucaphuka.
- Kwizigulane ezine-tuberculosis yokuphefumula esanda kufunyaniswa, unyango lwe-Noopept lunciphisa ukubonakaliswa kwexhala.
- Kwiigundane, ulawulo lwe-Noopept ludibaniswe nokunyuka komsebenzi we-locomotor kuvavanyo oluphakanyisiweyo lwe-plus-maze, ebonisa umphumo wokuchasana nokuxhalaba.
- Ulawulo lwe-Noopept luye lwandisa ukuziphatha kokuhlola kweempuku eziphantsi kovavanyo oluvulekileyo, olubonisa ukuncitshiswa kwexhala.
- Kwiimpuku, ulawulo lweNoopept luvelise ukumodareyitha kwinqanaba lokuxhalaba.
- Kwiigundane, i-Noopept yanciphisa iziganeko zokungancedi.
- Kwiimpuku ezivela kwiintlobo ezahlukeneyo, i-Noopept yanciphisa amanqanaba oxinzelelo njengoko kubonakaliswe linani elongezelelweyo lokuphendula ukuphepha kwi-stress-inducing slip-funnel test.
- Kwiigundane ezineminyaka eyi-4 iintsuku, i-Noopept iguqule iimpawu zoxinzelelo olubangelwa yi-corticotropin ekhupha i-hormone (CRH).
- Kwiintlobo zeegundane ezifakwe kwi-inbred, ulawulo lwe-Noopept kwi-1 mg ngekhilogram imihla ngemihla luvelise iziphumo ezichasene nokuxhalaba ngosuku lwe-7.
Ukuphucula iMood
I-Noopept inokunceda ukuphucula isimo sengqondo, iyenze ibe yindlela yonyango enokubakho kwiingxaki ezithile zempilo yengqondo:
- Ulawulo lwexesha elide lwe-Noopept (iintsuku ze-21) lwaphelisa kakhulu ukubonakaliswa kokungancedi okufundiweyo xa kuthelekiswa neyeza elichasayo i-Afobazol.
- Ulawulo olungapheliyo (iintsuku ze-28, i-0.5 mg / ngosuku ngee-injection) ze-Noopept eziphuculweyo zokuziphatha ngokunciphisa umsebenzi we-kinases owenziwe ngoxinzelelo (obandakanyekayo kwiingxaki zengqondo) kunye nokwandisa amanqanaba e-BDNF.
Isishwankathelo, i-Noopept yikhompawundi ethembisayo kunye neenzuzo ezinokuthi zibe khona kumsebenzi wokuqonda, ukuxhalaba, kunye nomoya. I-Aogubio ngumthombo othembekileyo we-Noopept ephezulu kunye nezinye izinto ezisebenzayo ze-pharmacologically, ukuqinisekisa ukuba abathengi banokufikelela kwizisombululo ezithembekileyo, ezisebenzayo kwiimfuno zabo zempilo kunye nokuphila kakuhle. Ingaba isetyenziswe kwizongezelelo, amayeza, okanye ezinye izicelo, i-Noopept inamandla okwenza umehluko onentsingiselo kubomi babasebenzisi. Njengoko imfuno yezixhasi zengqondo zendalo iqhubeka nokukhula, i-AoguBio ihleli izibophelele ekuboneleleni ngeemveliso ezintsha ukuhlangabezana neemfuno ezihlala zitshintsha zabathengi bethu.
Ukubhalwa kwenqaku:UMiranda Zhang
Ixesha lokuposa: Mar-11-2024
