Izibonelelo ezingaziwayo zeCDP-Choline:

IiNzuzo ezili-10 eziqinisekisiweyo zeCiticoline (CDP-Choline)

Izifundo ezininzi zibonise ukuba i-CDP-choline iphumelele ngakumbi kune-phosphatidylcholine (PC) ekukhuseleni ukukhubazeka kwememori. Ukongezelela, kubonakaliswe ukwandisa i-PC synthesis kwingqondo, ngaloo ndlela ibe negalelo kwimiphumo yayo ye-neuroprotective. Ngelixa i-CDP-Choline ithelekiswa nokusebenza kakuhle kwi-Alpha-GPC, ibonelela ngeenzuzo ezibanzi ngakumbi zomsebenzi wokuqonda.

• I-Citicoline Yongeza Inkumbulo

I-Citicoline ibonakaliswe ukuphucula imemori.

Oku kubalelwa ngokuyinxenye kwindima yayo ekwandiseni amanqanaba e-acetylcholine, i-neurotransmitter ebalulekileyo kwinkumbulo nokufunda.

Izifundo ezininzi zibonise iziphumo zokuphucula imemori yeCiticoline.

Kolunye uphononongo, abantu abadala abadala abaneenkumbulo ezinxulumene neminyaka bathatha iCiticoline kwiiveki ze-12.

Abathathi-nxaxheba bophononongo bafumana nokuba yi-1,000 mg okanye i-500 mg ye-Citicoline yonke imihla.

Baye bafumana ukuphuculwa kwenkumbulo emva kokuyithatha.

Abaphandi baye bahlola imiphumo yeCiticoline kubasetyhini abadala abanempilo.

Abasetyhini bathatha i-250 mg okanye i-500 mg iidosi zemihla ngemihla ye-Citicoline kwiintsuku ze-28.

Kuye kwakhokelela ekuphuculweni okuphawulekayo ekusebenzeni kwengqondo, kuquka imemori.

Ekugqibeleni, iqela labaphandi lihlalutye izifundo ezahlukeneyo kwimiphumo yeCiticoline ekubuyiseleni i-stroke.

Baye bagqiba ukuba izigulane ezifumene i-Citicoline zibonise ukuphuculwa kwememori kunye nokusebenza kwengqondo.

Ezi zifundo, phakathi kwezinye, zibonelela ngobungqina obuqinileyo kwimiphumo yokuphucula imemori yeCiticoline.

• I-Citicoline Iphucula Ugxininiso kunye neNgqwalasela

I-Citicoline ixhasa ukuhlanganiswa kwee-neurotransmitters ezibalulekileyo, ezifana ne-acetylcholine kunye ne-dopamine, ezidlala indima ebalulekileyo kwingqalelo kunye nokugxila.

Ngokwandisa ukufumaneka kwezi neurotransmitters, i-Citicoline inceda ukuphucula ingqalelo kunye nokugxila.

Uphando lufumanise oku kuyinyaniso.

Izifundo ezininzi zibonise ukuba ukuxhaswa kwe-Citicoline kunokunceda ukonyusa ingqwalasela, ukugxila kunye nokugxila.

Kwisifundo esinye, abafazi abadala abasempilweni bathatha i-250-500 mg idosi yemihla ngemihla yeCiticoline kwiintsuku ezingama-28.

Abaphandi bafumanisa ukuba abafazi bafumana ukuphuculwa okuphawulekayo ekusebenzeni kokuqwalaselwa .

Kolunye uphononongo, abaphandi bafumanise ukuba abantu abadala abasempilweni abathathe iCiticoline iiveki ezintandathu bafumana uphuculo kwingqwalasela kunye nokusebenza kwengqondo.

Kwaye ke i-randomized, i-double-blind-blind, i-placebo-controlled controlled study ijonge kwimiphumo ye-Citicoline ekusebenzeni kwengqondo kumavolontiya angamadoda anempilo.

Abaphandi bafumanisa ukuba abathathi-nxaxheba abafumana i-Citicoline babonise ukuphuculwa okuphawulekayo kwingqwalasela, imemori yokusebenza, kunye nokuguquguquka kwengqondo.

Uthathela ingqalelo lonke olu phando, kucace gca ukuba iCiticoline inokuba luncedo ngakumbi kubafundi, iingcali, okanye nabani na ofuna ukuphucula ukugxila kwabo kunye nokusebenza kwengqondo iyonke.

• I-Citicoline yi-Neuroprotective

I-Citicoline yaziwa ngokuba yi-neuroprotective.

Ikhusela iiseli zengqondo kumonakalo kunye nokonakala.

Ikwenza oku ngokugcina ingqibelelo yeembumba zeeseli, ukunciphisa uxinzelelo lwe-oxidative, kunye nokunciphisa ukuvuvukala kwingqondo.

Ezi ziphumo zinegalelo kwimpilo yobuchopho ngokubanzi. Banokukhusela ngokuchasene nokuncipha kwengqondo kunye neemeko ze-neurodeergenerative.

Izifundo ezininzi zibonise iziphumo ze-neuroprotective zeCiticoline, ngakumbi kwiimeko ze-ischemic stroke, ukwenzakala kwengqondo okubuhlungu, kunye nokuncipha kwengqondo.

Abaphandi bafumanisa ukuba i-Citicoline inokunceda ukulawula amanqanaba e-glutamate, i-neurotransmitter enomdla. I-Glutamate inokubangela umonakalo we-neuronal xa ikhona kwiimali ezigqithisileyo.

• I-Citicoline iNcedisa ngokuBuyisa i-Stroke

Ucwaningo luye lwabonisa ukuba i-Citicoline inokunceda kwinkqubo yokubuyisela emva kokuphazamiseka.

Ikwenza oku ngokuphucula iplastiki yengqondo, ukukhuthaza ukukhula koqhagamshelwano olutsha lwe-neural, kunye nokunciphisa ukudumba kunye nomonakalo we-neuronal.

Ngenxa yoko, isoloko isetyenziswa njengonyango olongezelelweyo kunye nonyango oluqhelekileyo lwe-stroke.

I-Citicoline ibonakala iluncedo kakhulu kwizigulane eziye zahlaselwa yi-ischemic strokes.

I-Ischemic stroke yenzeka xa ukuhamba kwegazi kwingqondo kuvaliwe, okukhokelela ekunqongophelweni kwe-oksijini kunye nezondlo. Oku kunokubangela ukufa kweeseli kunye nomonakalo wemithambo-luvo.

Uhlalutyo oludibeneyo lwezilingo zeklinikhi lujonge iziphumo zeCiticoline kwi-acute ischemic stroke.

Abaphandi bafumanisa ukuba izigulane ezifumene i-Citicoline zafumana iziphumo eziphuculweyo zokusebenza kunye neengqondo.

Olunye uphononongo lophando luvavanye indima yeCiticoline kwi-neuroprotection kunye ne-neurorepair kwi-stroke ye-ischemic.

Ababhali baphetha ngokuthi i-Citicoline yayinyamezeleke ngokuqhelekileyo kwaye inokuphucula iziphumo ezisebenzayo kunye nengqondo kwizigulane ze-stroke. Oku bekuyinyani ngakumbi xa isetyenziswe kwangoko kwinkqubo yonyango .

• I-Citicoline iphucula iMood kunye neNkuthazo

I-Citicoline inxulunyaniswe kumanqanaba okwanda kwe-dopamine, i-neurotransmitter ehambelana nenkuthazo, ulonwabo kunye nomvuzo.

Esi siphumo sinokunceda ukuphucula isimo sengqondo, inkuthazo, kunye nokuphila kakuhle.

Ngenxa yoko, ezinye izifundo zicebise ukuba i-Citicoline ineempembelelo ezifana ne-antidepressant.

Kwesinye isifundo, abaphandi baphanda imiphumo ye-Citicoline yokuncedisa kwimoya kunye namandla engqondo.

Ulingo lubandakanya abantu abadala abangama-60 abasempilweni. Baye bafumana i-Citicoline (250 mg / ngosuku okanye i-500 mg / ngosuku) okanye i-placebo kwiiveki ezintandathu.

Abathathi-nxaxheba abafumana i-Citicoline bachaza ukuphuculwa kwemeko yabo kunye namandla engqondo .

• I-Citicoline iphucula ukuFunda

I-Citicoline ibonakaliswe ukuphucula ukufunda.

Ikwenza oku ngokuphakamisa imiba eyahlukeneyo yokusebenza kwengqondo, kubandakanya inkumbulo, ingqalelo, kunye neuroplasticity.

Kwisifundo esinye, abaphandi baphanda imiphumo yeCiticoline ekufundeni nasekukhumbuleni abantu abadala.

Olu lingo luquka abantu abadala abasempilweni abangama-60. Baye bafumana i-Citicoline (250 mg / ngosuku okanye i-500 mg / ngosuku) okanye i-placebo kwiintsuku ze-28.

Abaphandi bafumanisa ukuba abathathi-nxaxheba abafumana i-Citicoline babonise ukusebenza okuphuculweyo kwimisebenzi eyahlukeneyo yengqondo, kubandakanywa nezo zihambelana nokufunda.

• I-Citicoline Yongeza i-Acetylcholine kwi-Brain

I-acetylcholine yi-neurotransmitter ebalulekileyo ebandakanyeka kwiinkalo ezahlukeneyo zokusebenza kwengqondo, kuquka ukufunda, ukukhumbula kunye nokuqwalaselwa.

Xa i-Citicoline idliwe kwaye i-metabolized, idilizwe ibe yi-choline.

I-Choline inokuwela umqobo wegazi-ubuchopho kwaye ingene ebuchotsheni.

Kanye kwingqondo, i-choline isetyenziselwa ukwenza i-acetylcholine.

Ngenxa yoko, i-Citicoline ibonakaliswe ukwandisa amanqanaba e-choline kunye ne-acetylcholine kwingqondo. Oku ke kunegalelo ekuphuculeni ukusebenza kwengqondo.

Izifundo ezininzi zibonise ukuba ukuxhaswa kwe-Citicoline kunokukhokelela ekunyuseni kwamanqanaba e-acetylcholine kwingqondo.

Kwisifundo esinye, abaphandi baphanda iziphumo zeCiticoline kwi-cholinergic neurotransmission.

Iziphumo zabonisa ukuba i-Citicoline yonyuse ukukhutshwa kwe-acetylcholine kwi-hippocampus, engummandla wobuchopho obaluleke kakhulu ekufundeni nasekukhumbuleni.

Olunye uphononongo lujonge iziphumo zeCiticoline ekubonakalisweni kweempawu zeplastiki zengqondo.

Ababhali bafumanisa ukuba iCiticoline iholele ekunyukeni kwamanqanaba e-acetylcholine kwingqondo.

Ezi zimbini kuphela kwizifundo ezininzi ezibonisa ukuba ukuxhaswa kwe-Citicoline kunokunyusa amanqanaba e-acetylcholine kwingqondo.

• I-Citicoline Yehlisa Ukuvuvukala kwi-Brain

Ukuvuvukala kudlala indima ebalulekileyo ekuphuhliseni nasekuqhubeleni phambili kweengxaki ezahlukeneyo ze-neurological. Oku kubandakanya isifo sika-Alzheimer, isifo sika-Parkinson, kunye nesifo sokuwa.

Kodwa iCiticoline ibonakaliswe ukuba ineepropathi ezichasayo, kwaye inokunceda ukunciphisa ukudumba kwengqondo.

Ngokomzekelo, i-Citicoline inciphisa kakhulu ukuveliswa kwee-cytokines ezibangela ukudumba engqondweni.

Kwesinye isifundo, abaphandi bavavanya imiphumo yeCiticoline kwixinzelelo lwe-oxidative kunye nokuvuvukala kwimodeli yegundane ye-Alzheimer's disease.

Ababhali bafumanisa ukuba iCiticoline yanciphisa uxinzelelo lwe-oxidative kunye nokuvuvukala kwengqondo. Oku kuncitshiswa kokudumba kwakudityaniswa nokuphuculwa komsebenzi wokuqonda kwiimpuku.

Ngokunciphisa ukuvuvukala kwengqondo, i-Citicoline inokunceda ukugcina impilo yengqondo, kwaye incede ukukhusela ukuphuhliswa kwezifo ze-neurodeergenerative.

• I-Citicoline Yongeza iPlastiki yeBrain

Iplastiki yobuchopho bubuchule bobuchopho bokutshintsha kunye nokulungelelanisa ukuphendula kumava amatsha.

Iplastiki yobuchopho idlala indima ebalulekileyo ekwenziweni koqhagamshelo olutsha phakathi kwemithambo-luvo (synaptogenesis) kunye nokukhula kwemithambo-luvo entsha (neurogenesis).

Zombini i-synaptogenesis kunye ne-neurogenesis zibalulekile ekufundeni, kwimemori, kunye nokuchacha kukwenzakala kwengqondo.

I-Citicoline ibonakaliswe ukwandisa iplastiki yengqondo, i-synaptogenesis kunye ne-neurogenesis.

Kolunye uphononongo, abaphandi baphanda iziphumo ze-Citicoline ekubonakalisweni kweempawu zeplastiki zengqondo kwimodeli yegundane ye-stroke.

Iziphumo zibonise ukuba i-Citicoline iholele ekunyuseni ukubonakaliswa kweeprotheni ezinxulumene neplastiki kunye nezinto ezikhulayo, ezifana ne-BDNF kunye ne-NGF.

Olunye uphando lufumene ukuba iCiticoline iphucula iplastiki yengqondo kwaye ikhuthaza ukubuyiswa emva kokubetha.

• I-Citicoline iNcedisa ngokuncipha kwengqondo, ukuKhathazeka okuPhakamileyo kwengqondo, kunye nesifo se-Alzheimer.

Ukuncipha kwengqondo kubonakala ngokuncipha ngokuthe ngcembe kwimisebenzi yengqondo, kuquka inkumbulo, ingqalelo, kunye nezakhono zokusombulula iingxaki.

I-Citicoline ibonakaliswe ukunciphisa ukwehla kwengqondo, ngakumbi kubantu abalupheleyo kunye nabo bathwaxwa zizifo ze-neurodeergenerative ezifana nesifo se-Alzheimer's.

Izifundo ezininzi zibonise izibonelelo zeCiticoline ekunciphiseni ukuhla kwengqondo.

Olunye uphononongo lujonge iziphumo zexesha elide zeCiticoline kwizigulana ezisele zikhulile ezinokuphazamiseka kancinci kwengqondo.

Abaphandi bafumanise ukuba iinyanga ze-9 ze-Citicoline supplementation ziphucule kakhulu ukusebenza kwengqondo kwezi zigulana.

Olunye uphando luphande imiphumo yeCiticoline ekunciphiseni kwengqondo kwizigulane ezine-Alzheimer's disease.

Ulingo lufumene ukuba izigulane ezifumene i-Citicoline kwiinyanga ze-12 zifumana ukuhla kancinci ekusebenzeni kwengqondo.

Kwaye ke ukuphononongwa okucwangcisiweyo kuhlolwe ukusebenza kweCiticoline ekuphatheni ukuphazamiseka kwengqondo kunye nokuziphatha kwizigulane ezisebekhulile.

Ababhali baphetha ngokuthi i-Citicoline ibonise iingenelo ezithile ekuphuculeni iimpawu zengqondo kunye nokuziphatha kwezi zigulana.

Ukukwazi kweCiticoline ukucothisa ukuhla kwengqondo kunokubangelwa kwiindlela ezininzi. Inokuphucula imveliso ye-neurotransmitter, ixhase ingqibelelo ye-membrane yeseli yengqondo, yonyuse iplastiki yengqondo, kwaye inciphise ukudumba.