Zonke iiseli eziphilayo ziqulathenicotinamide adenine dinucleotide okanye NAD +. Iqukethe i-nucleotides nicotinamide mononucleotide (NMN) kunye ne-adenosine diphosphate (ADP), edityaniswe ne-pyrophosphate linkage. I-NAD + inokutshintsha ngokulula phakathi kokunciphisa kwayo (NADH) kunye ne-oxidized (NAD +) ithi ukuphendula kwiinkqubo ze-redox ethatha inxaxheba kuyo.
NAD+ isebenza njengomdlali ophambili kwiinkqubo ezahlukeneyo zeselula, kubandakanywa amandla e-metabolism, ukulungiswa kwe-DNA, kunye nokubonakaliswa kweeseli. Ukubandakanyeka kwayo kwezi nkqubo ikakhulu ngendima yayo njengomthwali we-electron, ukuvala ii-electron phakathi kwee-athomu ngexesha lokuphendula kwe-redox.
NAD + Indlela yeMetabolic
NAD+ imetabolism ibandakanya inethiwekhi entsonkothileyo ye-biosynthetic kunye neendlela zokusindisa. I-de novo biosynthesis ye-NAD+ iqala nge-amino acid tryptophan okanye i-nicotinic acid njenge-precursors, ekugqibeleni ifikelele ekusekweni kwe-NMN, ethi emva koko iguqulelwe kwi-NAD +. Kungenjalo, iiseli zinokusindisa i-NAD+ ngokusebenzisa iimolekyuli zangaphambili, ezinjenge-nicotinamide okanye i-nicotinic acid riboside, eziguqulwa zibe yi-NMN emva koko zibe yi-NAD+.
Indlela yokusindisa ibaluleke kakhulu ekugcineni amanqanaba e-NAD+, ngakumbi ngexesha leemeko zemfuno ephezulu yamandla okanye ukufumaneka kwe-precursor okulinganiselweyo. Ivumela iiseli ukuba ziphinde zisebenzise kwakhona kwaye zisebenzise kwakhona iimolekyuli ze-NAD +, zithintele ukuncipha kwazo kunye nokuqinisekisa ukubonelela ngokuqhubekayo kwiinkqubo ezibalulekileyo ze-metabolic.
IiNzuzo ezinokubakho
NAD+ ibalulekile kulondolozo lweentlobo zemitochondrial kunye nolawulo lwemfuza malunga nokuguga. Nangona kunjalo, inqanaba le-NAD + emzimbeni wethu lehla kakhulu ngenxa yobudala. “Njengoko sikhula, siphulukana ne-NAD +. Xa ufikelela kwiminyaka engama-50 ubudala, umalunga nesiqingatha somgangatho owawunawo xa wawuneminyaka engama-20 ubudala,” watsho njalo uDavid Sinclair weYunivesithi yaseHarvard kudliwano-ndlebe.
Uphononongo lubonise ukuhla kwemolekyuli enxulumana nezifo ezinxulumene nobudala kubandakanya ukuguga okukhawulezileyo, ukuphazamiseka kwemetabolism, isifo sentliziyo, kunye ne-neurodegeneration. Amanqanaba asezantsi e-NAD + anxulunyaniswa nesifo esinxulumene nobudala ngenxa yokusebenza kancinci kwemetabolism. Kodwa ukuzalisa amanqanaba e-NAD + kubonisiwe
iziphumo zokuchasana nokuguga kwiimodeli zezilwanyana, ezibonisa iziphumo ezithembisayo zokuguqula izifo ezinxulumene neminyaka, ukwandisa ixesha lokuphila kunye nempilo.
- Ukuguga
Eyaziwa ngokuba “ngabagadi begenomes,” iisirtuins ngamalungu emfuza akhusela izinto eziphilayo, ukusuka kwizityalo ukuya kwizilwanyana ezanyisayo, ekuwohlokeni nakwizifo. Xa imizila yemfuza ibona ukuba umzimba uphantsi koxinzelelo lomzimba, njengokuzilolonga okanye ukulamba, ithumela imikhosi ukuya kukhusela umzimba. I-Sirtuins igcina ingqibelelo ye-genome, ikhuthaza ukulungiswa kwe-DNA kwaye ibonise iipropati ezinxulumene nokuguga kwizilwanyana zemodeli ezifana nokwandisa ubomi.
I-NAD + ngamafutha aqhuba imfuza ukuba isebenze. Kodwa njengemoto ayinakuqhuba ngaphandle kwepetroli, iisirtuins zifuna i-NAD +. Iziphumo ezivela kwizifundo zibonisa ukuba ukuphakamisa inqanaba le-NAD + emzimbeni kuvula i-sirtuins kwaye kwandisa ixesha lokuphila kwigwele, iintshulube, kunye neempuku. Nangona ukuzalisa kwakhona kwe-NAD+ kubonisa iziphumo ezithembisayo kwiimodeli zezilwanyana, izazinzulu zisafunda ukuba ezi ziphumo zinokuguqulela njani ebantwini.
- Umsebenzi wezihlunu
Njengendlu yamandla yomzimba, umsebenzi we-mitochondrial ubalulekile ekusebenzeni kwethu komthambo. I-NAD+ yenye yezitshixo zokugcina i-mitochondria esempilweni kunye nokuphuma kwamandla okuzinzileyo.
Ukonyusa amanqanaba e-NAD + kwisihlunu kunokuphucula i-mitochondria kunye nokomelela kwiimpuku. Olunye uphononongo lukwabonisa ukuba iimpuku ezithatha i-NAD + boosters ziyabhitya kwaye zinokubaleka ziqhubele phambili kwi-treadmill, zibonisa umthamo ophezulu wokuzilolonga. Izilwanyana ezikhulileyo ezinezinga eliphezulu le-NAD + zigqwesa iintanga zayo.
- Ukuphazamiseka kweMetabolic
Echazwa njengobhubhani yiWorld Health Organization (WHO), ukutyeba sesinye sezifo ezixhaphakileyo kuluntu lwanamhlanje. Ukutyeba kakhulu kunokukhokelela kwezinye iziphazamiso zemetabolism ezifana nesifo seswekile, esibulale abantu abazizigidi ezisisi-1.6 kwihlabathi liphela ngo-2016.
Ukwaluphala kunye nokutya okunamafutha aphezulu kunciphisa inqanaba le-NAD + emzimbeni. Uphononongo lubonise ukuba ukuthatha i-NAD + boosters kunokunciphisa ubunzima obunxulumene nokutya kunye nobudala obunxulumene nobudala kwiimpuku kunye nokuphucula umthamo wabo wokuzilolonga, nakwiimpuku ezindala. Olunye uphononongo lude lwayibuyisela umva isiphumo seswekile kwiimpuku zabasetyhini, ebonisa iindlela ezintsha zokulwa nokuphazamiseka kwemetabolism.
- Umsebenzi wentliziyo
Ukunwebeka kwemithambo kusebenza njengesithinteli phakathi kwamaza oxinzelelo athunyelwa kukubetha kwentliziyo. Kodwa imithambo iyaqina njengoko sikhula, inegalelo kuxinzelelo lwegazi oluphezulu, ezona zinto zibalulekileyo kwimingcipheko yesifo sentliziyo. Umntu omnye ubulawa sisifo sentliziyo rhoqo kwimizuzwana engama-37 eUnited States kuphela, iCDC inikela ingxelo.
Uxinzelelo lwegazi oluphezulu lunokubangela ukuba intliziyo ibe nkulu kwaye ivale imithambo ekhokelela kwistroke. Ukonyusa amanqanaba e-NAD + kunika ukhuseleko entliziyweni, ukuphucula imisebenzi yentliziyo. Kwiimpuku, ii-boosters ze-NAD+ ziphinde zazalisa amanqanaba e-NAD+ entliziyweni ukuya kumanqanaba asisiseko kwaye athintele ukwenzakala entliziyweni okubangelwa kukungabikho kokuhamba kwegazi. Olunye uphononongo lubonise ukuba i-NAD+ boosters inokukhusela iimpuku ekwandiseni kwentliziyo okungaqhelekanga.
- Neurodegeneration
Ngo-2050, abantu behlabathi abaneminyaka engama-60 nangaphezulu kuqikelelwa ukuba baya ku-2 yeebhiliyoni, phantse kabini inani lika-2015, ngokutsho kwe-WHO. Abantu ehlabathini lonke baphila ixesha elide. Nangona kunjalo, ukwaluphala ngowona mngcipheko uphambili wezifo ezininzi ze-neurodeergenerative kubandakanya isifo sikaParkinson kunye ne-Alzheimer's, ebangela ukuphazamiseka kwengqondo.
Kwiimpuku ezine-Alzheimer's, ukuphakamisa inqanaba le-NAD+ kunokunciphisa ukwakhiwa kweprotheyini ephazamisa unxibelelwano lweeseli kunye nokwandisa ukusebenza kwengqondo. Ukonyusa amanqanaba e-NAD+ kukwakhusela iiseli zobuchopho ekufeni xa kukho ukuhamba kwegazi okwaneleyo engqondweni. Izifundo ezininzi kwiimodeli zezilwanyana zibonisa amathuba amatsha okunceda ubuchopho bukhule busempilweni kwaye bukhusele ngokuchasene ne-neurodegeneration.
Nceda uqhagamshelane no-Alisa nge-COA kunye neenkcukacha zexabiso nge-sales02@imaherb.com
Ixesha lokuposa: Dec-26-2023
