Ukuvula i-Anti-Cancer Potential ye-N-Acetylcysteine

I-N-acetylcysteine ​​(NAC) ipowder, i-derivative ye-amino acid cysteine, sele iqatshelwe ngenxa yeempawu zayo ezinamandla zokulwa ne-antioxidant. Ifumene ingqwalasela enkulu kwiminyaka yakutshanje ngenxa yeziphumo zayo zokuchasa umhlaza. Abaphandi bebephonononga amandla ayo okuthintela nokunyanga iintlobo ezahlukeneyo zomhlaza, kwaye iziphumo bezithembisa.

Umhlaza sisifo esintsonkothileyo esibonakaliswa kukukhula okungalawulekiyo kunye nokwahlukana kweeseli ezingaqhelekanga. Uxinzelelo lwe-oxidative, olubangelwa kukungalingani phakathi kwemveliso yeeradicals zasimahla kunye nokukwazi komzimba ukuzinciphisa, kwaziwa ngokudlala indima ebalulekileyo kuphuhliso lomhlaza. I-NAC isebenza njenge-antioxidant enamandla, inceda ukunciphisa uxinzelelo lwe-oxidative kunye nokukhusela iiseli emonakalweni.

Izifundo ezininzi zibonise ukuba i-NAC inokuthintela ukukhula kweeseli zomhlaza kwaye ibangele ukufa kwabo, inkqubo eyaziwa ngokuba yi-apoptosis. Ibonakaliswe isebenza ngokuchasene noluhlu lwemihlaza, kubandakanya imiphunga, ibele, ikholoni, kunye nomhlaza wedlala lobudoda. Kumhlaza wemiphunga, umzekelo, i-NAC ifunyenwe inqanda ukukhula kunye ne-metastasis yeeseli zomhlaza ngokucinezela umsebenzi weeproteni ezithile ezibandakanyekayo kuphuhliso lwethumba.

Ngaphaya koko, i-NAC ibonisiwe ukuba yonyusa ukusebenza konyango oluqhelekileyo lomhlaza olunje ngechemotherapy kunye nemitha. Inokuthi isebenze njenge-chemosensitizer, eyenza iiseli zomhlaza zichaphazeleke ngakumbi kwiziphumo ze-cytotoxic zamachiza e-chemotherapy. Ngokunyusa amanqanaba e-intracellular emolekyuli ebizwa ngokuba yi-glutathione, i-NAC inceda ekunciphiseni iziphumo ezinobungozi zamachiza e-chemotherapy kwiiseli eziqhelekileyo ngelixa ivuselela iiseli zomhlaza kunyango.

Omnye umba onomdla we-NAC's anti-cancer amandla kukukwazi ukumodareyitha amajoni omzimba. Amajoni omzimba adlala indima ebalulekileyo ekuqondeni nasekupheliseni iiseli zomhlaza. I-NAC ifunyenwe ukunyusa umsebenzi weeseli ezithile zokuzivikela, ezifana neeseli ezibulalayo zendalo kunye neeseli ze-T, ezinoxanduva lokubona nokubulala iiseli zomhlaza. Ngokwandisa ukusebenza komzimba, i-NAC inokunceda ukuphucula iindlela zokuzikhusela zendalo kumhlaza.

Ukongeza kwiipropathi zayo ze-antioxidant kunye ne-immune-enhating, i-NAC ikwabonakaliswe ukuba ineempembelelo zokuchasa ukudumba. Ukuvuvukala okungapheliyo kuhambelana ngokusondeleyo nophuhliso kunye nokuqhubela phambili komhlaza. Ngokunciphisa ukuvuvukala, i-NAC inokunceda ukukhusela ukuqaliswa kunye nokukhula kwamathumba.

Ngaphandle kweziphumo ezithembisayo, uphando oluthe kratya luyafuneka ukuze kuqondwe ngokupheleleyo iindlela ezisisiseko seziphumo zokulwa nomhlaza ze-NAC kunye nokumisela elona thamo liphezulu kunye nobude bexesha lonyango. Ulingo lwezonyango luyaqhubeka ngoku ukuhlola ukhuseleko nokusebenza kwe-NAC kuthintelo nakunyango lomhlaza. Kubalulekile ukuqaphela ukuba i-NAC kufuneka isetyenziswe phantsi kwesikhokelo sabasebenzi bezempilo, njengoko inokunxibelelana namayeza athile kwaye ibe neziphumo ebezingalindelekanga.

Ekugqibeleni, i-N-acetylcysteine ​​powder ibonisa isithembiso esikhulu ekuvuleni amandla okulwa nomhlaza. Ukusuka kwiipropathi zayo zokulwa ne-antioxidant kunye ne-immune-zomeleza umzimba ukuya kwisakhono sayo sokwazisa iiseli zomhlaza kunyango oluqhelekileyo, i-NAC ibambe amandla amakhulu njengonyango olongezelelweyo kumlo ochasene nomhlaza. Nangona kunjalo, uphando olongezelelweyo luyimfuneko ukuze lusebenzise ngokupheleleyo izibonelelo zalo kwaye ludibanise kunyango oluqhelekileyo lomhlaza.