I-N-Acetylcysteine ​​kanye Namandla ayo Okuvimbela Ukulimala Kwesibindi Okubangelwa Izidakamizwa

I-N-Acetylcysteine ​​(NAC) ivame ukutholakala ku-capsule noma ifomu le-powder futhi ithole ukuqashelwa kwamandla ayo ekuvimbeleni ukulimala kwesibindi okubangelwa izidakamizwa. Isibindi siyisitho esibalulekile esinomthwalo wemfanelo wokugaya izidakamizwa nobuthi, futhi ukuchayeka isikhathi eside emithini ethile kungaholela ekulimaleni kwesibindi. Kulesi sihloko, sizohlola izinzuzo ze-N-Acetylcysteine ​​nokuthi ingasivikela kanjani isibindi emonakalweni obangelwa izidakamizwa.

I-N-Acetylcysteine, isandulela se-amino acid cysteine, yaziwa ngezindawo zayo zokulwa ne-antioxidant. Isebenza ngokugcwalisa i-glutathione, i-antioxidant enamandla ekhona ngokwemvelo emzimbeni, ngaleyo ndlela ivikela amangqamuzana ekucindezelekeni kwe-oxidative. Le ndlela yokusebenza yenza i-NAC ibe yikhandidethi elithembisayo lokuvimbela ukulimala kwesibindi okubangelwa izidakamizwa, njengoba ukucindezeleka okwenziwe nge-oxidative kudlala indima ebalulekile ekwakhiweni kokulimala kwesibindi.

Ucwaningo oluningana lubonise amandla e-N-Acetylcysteine ​​ekuvimbeleni ukulimala kwesibindi okubangelwa imithi ehlukahlukene. Isibonelo, i-acetaminophen (i-paracetamol) iyi-analgesic esetshenziswa kabanzi engabangela ukulimala okukhulu kwesibindi ezimeni ze-overdose. I-NAC iboniswe ukuthi inciphise ngempumelelo i-acetaminophen-induced hepatotoxicity ngokuvimbela ukuchithwa kwe-glutathione, ukunciphisa ukucindezeleka kwe-oxidative, nokunciphisa ukukhiqizwa kwama-metabolites anobuthi.

Ngaphezu kwe-acetaminophen, ezinye izidakamizwa ezifana nezidakamizwa ezingezona ukuvuvukala (ama-NSAID), ama-statins, nama-antibiotic athile ahlotshaniswa ne-hepatotoxicity. I-N-Acetylcysteine ​​ibonise isithembiso ekuvikeleni ukulimala kwesibindi okubangelwa yile mithi futhi. Ngokunciphisa ama-metabolites anobuthi, ukunciphisa ukuvuvukala, nokukhuthaza ukuvuselelwa kwamangqamuzana esibindi, i-NAC ingakwazi ukuvimbela ukuqhubeka kokulimala kwesibindi okubangelwa izidakamizwa futhi ilondoloze ukusebenza kwesibindi.

Ngaphezu kwalokho, i-N-Acetylcysteine ​​​​ifundwe ngokusiza kwayo ekuvimbeleni ukulimala kwesibindi kubantu abanezimo ezithile zezokwelapha. Isibonelo, abantu abane-hepatitis C engapheli bavame ukubhekana nengozi eyengeziwe yokuthuthukisa i-fibrosis yesibindi kanye ne-cirrhosis. Ucwaningo luye lwabonisa ukuthi ukwesekwa kwe-NAC kungathuthukisa ukusebenza kwesibindi kulezi ziguli, njengoba kusiza ukunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative.

Ngaphandle kwezakhiwo zayo zokuvikela isibindi, i-N-Acetylcysteine ​​​​iphenywe amandla ayo ekwelapheni ezinye izimo ezinjengokuphazamiseka kokuphefumula, ukuphazamiseka kwengqondo, nokusebenzisa kabi izidakamizwa. Isetshenziswe njenge-ejenti ye-mucolytic ezimeni ezifana nesifo se-chronic obstructive pulmonary (COPD) kanye ne-cystic fibrosis, lapho isiza khona ukudiliza amafinyila futhi ithuthukise ukucaciswa kwendlela yomoya. Ukwengeza, i-NAC ibonise isithembiso ekulawuleni ukuphazamiseka kwengqondo okufana ne-bipolar disorder kanye ne-obsessive-compulsive disorder ngenxa yendima yayo ekulinganiseni amazinga e-glutamate ebuchosheni.

Ekuphetheni, i-N-Acetylcysteine ​​​​e-capsule noma ifomu le-powder inamandla okuvimbela ukulimala kwesibindi okubangelwa izidakamizwa. Izici zayo ze-antioxidant kanye nekhono lokugcwalisa i-glutathione kuyenza ibe ikhandidethi eliphumelelayo lokunciphisa ukucindezeleka kwe-oxidative nokunciphisa ukulimala kwesibindi okubangelwa imithi ethile. Ngaphezu kwalokho, i-NAC ibonise isithembiso ekwelapheni ezinye izimo zezokwelapha ezifana nokuphefumula kanye nesifo sengqondo. Kodwa-ke, kubalulekile ukubonana nochwepheshe bezempilo ngaphambi kokuqala i-N-Acetylcysteine ​​supplementation njengoba kungase kube nokuhlukahluka komuntu ngamunye kumthamo nokufaneleka.