Wonke amaseli abukhoma aquketheI-nicotinamide adenine dinucleotidenoma i-NAD+. Iqukethe i-nucleotides nicotinamide mononucleotide (NMN) kanye ne-adenosine diphosphate (ADP), ehlanganiswe ukuxhumana kwe-pyrophosphate. I-NAD+ ingase ishintshe kalula phakathi kwezifunda zayo ezincishisiwe (NADH) kanye ne-oxidized (NAD+) ngokuphendula izinqubo ze-redox ebamba iqhaza kuzo.
NAD+isebenza njengomdlali oyinhloko ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa amandla e-metabolism, ukulungiswa kwe-DNA, nokusayina kwamaseli. Ukubandakanyeka kwayo kulezi zinqubo ikakhulukazi ngendima yayo njengesithwali se-electron, ukuvala ama-electron phakathi kwama-molecule ngesikhathi sokusabela kwe-redox.
I-NAD+ Metabolic Pathway
NAD+I-metabolism ihilela inethiwekhi eyinkimbinkimbi ye-biosynthetic kanye ne-salvage pathways. I-de novo biosynthesis ye-NAD+ iqala nge-amino acid tryptophan noma i-nicotinic acid njengama-precursors, ekugcineni ifinyelele ekwakhekeni kwe-NMN, ebese iguqulelwa ku-NAD+. Kungenjalo, amaseli angakwazi ukuhlenga i-NAD+ ngokusebenzisa ama-molecule angaphambili, njenge-nicotinamide noma i-nicotinic acid riboside, aguqulelwa ku-NMN bese kuba i-NAD+.
Indlela yokuhlenga ibaluleke kakhulu ekugcineni amazinga e-NAD+, ikakhulukazi phakathi nezimo zesidingo esikhulu samandla noma ukutholakala kwesandulela esilinganiselwe. Ivumela amaseli ukuthi asebenzise kabusha futhi asebenzise kabusha ama-molecule e-NAD+, avimbele ukuncipha kwawo futhi aqinisekise ukuhlinzekwa okuqhubekayo kwezinqubo ezibalulekile ze-metabolic.
Izinzuzo ezingaba khona
NAD+ibalulekile ekugcinweni kwe-mitochondrial yezilwane kanye nokulawulwa kofuzo mayelana nokuguga. Kodwa-ke, izinga le-NAD + emzimbeni wethu lehla kakhulu ngokuya ngeminyaka. “Njengoba sikhula, silahlekelwa yi-NAD+. Lapho usuhlanganisa iminyaka engu-50, usuke usunengxenye yezinga owake waba nalo lapho uneminyaka engu-20,” kusho uDavid Sinclair waseHarvard University engxoxweni.
Ucwaningo luye lwabonisa ukwehla kwe-molecule ehlotshaniswa nezifo ezihlobene neminyaka ehlanganisa ukuguga okusheshayo, ukuphazamiseka kwe-metabolic, isifo senhliziyo, kanye ne-neurodegeneration. Amazinga aphansi e-NAD+ ahlotshaniswa nesifo esihlobene neminyaka ngenxa yokusebenza kancane kwemetabolism. Kepha ukugcwalisa amazinga e-NAD+ kuveziwe
imiphumela elwa nokuguga kumamodeli ezilwane, ebonisa imiphumela ethembisayo ekubuyiseleni emuva izifo ezihlobene nobudala, ukwandisa isikhathi sokuphila kanye nempilo.
- Ukuguga
Aziwa ngokuthi “abaqaphi bezakhi zofuzo,” ama-sirtuin ayizakhi zofuzo ezivikela izinto eziphilayo, ezitshalweni kuya ezilwaneni ezincelisayo, ekuwohlokeni nasezifweni. Lapho izakhi zofuzo zizwa ukuthi umzimba ungaphansi kokucindezeleka ngokomzimba, njengokuzivocavoca noma ukulamba, kuthumela amasosha ukuba avikele umzimba. Ama-Sirtuin agcina ubuqotho be-genome, akhuthaza ukulungiswa kwe-DNA futhi abonise izici ezihlobene nokuguga ezilwaneni eziyimodeli njengokukhula kwesikhathi sokuphila.
I-NAD+ inguphethiloli oshayela ufuzo ukuthi lusebenze. Kepha njengemoto ayikwazi ukushayela ngaphandle kukaphethiloli wayo, ama-sirtuin adinga i-NAD +. Imiphumela evela ocwaningweni ikhombisa ukuthi ukukhuphula izinga le-NAD+ emzimbeni kwenza ama-sirtuin asebenze futhi kwandisa isikhathi sokuphila kumvubelo, izikelemu namagundane. Yize ukugcwalisa kabusha kwe-NAD+ kukhombisa imiphumela ethembisayo kumamodeli ezilwane, ososayensi basatadisha ukuthi le miphumela ingahumusha kanjani kubantu.
- Ukusebenza kwemisipha
Njengendlu yamandla yomzimba, umsebenzi we-mitochondrial ubalulekile ekusebenzeni kwethu kokuzivocavoca. I-NAD+ ingenye yezikhiye zokugcina i-mitochondria enempilo kanye nokuphuma kwamandla okuzinzile.
Ukwenyusa amazinga e-NAD+ emisipha kungathuthukisa i-mitochondria nokuqina kumagundane. Olunye ucwaningo luphinde lubonise ukuthi amagundane athatha ama-booster e-NAD+ ayacile futhi angagijima aqhubekele phambili ku-treadmill, ekhombisa umthamo wokuzivocavoca ophakeme. Izilwane esezikhulile ezinezinga eliphakeme le-NAD+ zidlula ontanga yazo.
- Izinkinga ze-metabolic
Njengoba iWorld Health Organization (WHO) imemezele njengobhubhane, ukukhuluphala ngokweqile kungesinye sezifo ezivame kakhulu emphakathini wanamuhla. Ukukhuluphala ngokweqile kungaholela kwezinye izifo ze-metabolic ezifana nesifo sikashukela, esabulala abantu abayizigidi ezingu-1.6 emhlabeni wonke ngo-2016.
Ukuguga nokudla okunamafutha amaningi kunciphisa izinga le-NAD+ emzimbeni. Ucwaningo lukhombisile ukuthi ukuthatha ama-booster e-NAD+ kungadambisa ukuzuza kwesisindo okuhambisana nokudla nokuhambisana neminyaka kumagundane futhi kuthuthukise amandla awo okuzivocavoca, ngisho nasemagundaneni amadala. Olunye ucwaningo lwaze lwawuhlehlisa umphumela wesifo sikashukela kumagundane esifazane, lubonisa amasu amasha okulwa nokuphazamiseka kwe-metabolic.
- Umsebenzi wenhliziyo
Ukunwebeka kwemithambo kusebenza njengesivimbeli phakathi kwamagagasi okucindezela athunyelwa ukushaya kwenhliziyo. Kodwa imithambo iyaqina njengoba siguga, okubangela umfutho wegazi ophakeme, izici eziyingozi kakhulu zesifo senhliziyo nemithambo yegazi. Umuntu oyedwa ubulawa isifo senhliziyo njalo ngemizuzwana engu-37 e-United States iyodwa, kubika i-CDC.
Umfutho wegazi ophakeme ungabangela inhliziyo ukuba ibe nkulu futhi kuvaleke imithambo eholela ekushayweni. Ukuthuthukisa amazinga e-NAD+ kunikeza isivikelo enhliziyweni, kuthuthukise imisebenzi yenhliziyo. Emagundaneni, ama-booster e-NAD+ agcwalise amazinga e-NAD+ enhliziyweni ukuze afinyelele emazingeni ayisisekelo futhi avimbele ukulimala kwenhliziyo okubangelwa ukushoda kokugeleza kwegazi. Olunye ucwaningo lubonise ukuthi ama-booster e-NAD+ angavikela amagundane ekwandeni kwenhliziyo okungavamile.
- I-Neurodegeneration
Ngo-2050, inani labantu emhlabeni abaneminyaka yobudala engama-60 nangaphezulu kulindeleke ukuthi libe yizigidi eziyizinkulungwane ezimbili, elicishe liphindeke kabili inani lika-2015, ngokusho kwe-WHO. Abantu emhlabeni wonke baphila isikhathi eside. Kodwa-ke, ukuguga kuyisici esiyinhloko sengozi yezifo eziningi ze-neurodegenerative kuhlanganise nesifo sika-Parkinson kanye ne-Alzheimer's, okubangela ukukhubazeka kwengqondo.
Emagundaneni ane-Alzheimer's, ukuphakamisa izinga le-NAD+ kunganciphisa ukwakheka kwamaprotheni aphazamisa ukuxhumana kwamaseli futhi kukhuphule ukusebenza kwengqondo. Ukukhulisa amazinga e-NAD+ futhi kuvikela amangqamuzana obuchopho ekufeni lapho kunokugeleza kwegazi okwanele ukuya ebuchosheni. Ucwaningo oluningi kumamodeli ezilwane luveza amathuba amasha okusiza ubuchopho buguge bunempilo futhi buvikele ekuwohlokeni kwemizwa.
Sicela uxhumane no-Alisa nge-COA kanye nemininingwane yentengo nge-sales02@imaherb.com
Isikhathi sokuthumela: Dec-26-2023
