Yintoni iAdenosine?

I-Adenosine yi-nucleoside eyenzeka ngokwemvelo kuzo zonke iiseli zomzimba. Ngokwemichiza yi-6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Ubume kunye namanqanaba egazi

I-Adenosine yenziwe nge-adenine edityaniswe kwimolekyuli yeswekile ye-ribose (ribofuranose) moiety. Ibhondi edibanisa i-adenine kunye ne-ribose iswekile ibizwa ngokuba yi-β-N9-glycosidic bond.

Inqanaba le-plasma adenosine eliqhelekileyo liphakathi kwe-0.04 kunye ne-0.2 micromoles.

Indima yePhysiological and pharmacological of Adenosine

Emzimbeni, i-adenosine inceda ekudluliselweni kwamandla eselula ngokwenza iimolekyuli ezifana ne-adenosine triphosphate (ATP) kunye ne-adenosine diphosphate (ADP).

I-Adenosine ikwadlala indima ekuboniseni iindlela ezahlukeneyo kunye nemisebenzi emzimbeni ngokwenza iimolekyuli ezinophawu njenge-cyclic adenosine monophosphate (cAMP).

Adenosine kwingqondo

Kwingqondo i-adenosine yi-neurotransmitter ethintelayo. Oku kuthetha ukuba, i-adenosine inokusebenza njenge-central nervous system depressant. Kwiimeko eziqhelekileyo, ikhuthaza ukulala kwaye icinezela ukuvuswa. Xa uvukile amanqanaba e-adenosine ebuchotsheni aphakama ngeyure nganye.

Adenosine entliziyweni

Kwintliziyo i-adenosine ibangela ukwanda kwemithambo yegazi ephucula ukujikeleza kwegazi entliziyweni. I-Adenosine ikwanyusa i-diameter yemithambo yegazi kumalungu eperipheral.

Kwintliziyo i-adenosine yehlisa izinga lokubetha kwentliziyo kwaye egazini inesenzo esichasene neplatelet. Isenzo se-Antiplatelet sithintela ukuhlanganiswa kweplatelet kunye nokudibanisa.

Adenosine egazini

Kwigazi i-adenosine yophulwa yi-adenosine deaminase. Le enzyme ikhona kwiiseli ezibomvu kunye nodonga lwesitya. Ichiza elithi Dipyridamole liyi-inhibitor ye-enzyme i-adenosine deaminase kwaye ngaloo ndlela iphakamisa amanqanaba e-adenosine egazini. Oku kukhokelela ekuvulekeni kwemithambo yegazi kunye nokuphucula ukuhamba kwegazi kwimithambo yegazi ye-coronary enikezela imisipha yentliziyo.

I-Adenosine kwizintso, imiphunga kunye nesibindi

Kwizintso i-adenosine yehlisa ukuhamba kwegazi kwizintso kwaye yehlise imveliso ye-rennin evela kwizintso.

Kwimiphunga ibangela ukuxinana kwemijelo yomoya kwaye esibindini ikhokelela ekuxineni kwemithambo yegazi kwaye inyusa ukophuka kwe-glycogen yenze iswekile.

I-Adenosine yikhompawundi eyenzeka ngokwemvelo edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zomzimba kumzimba womntu. I-nucleoside, oku kuthetha ukuba yenziwe nge-adenine molekyuli edityaniswe ne-ribose molekyuli. I-Adenosine ikhona kuzo zonke iiseli kwaye ibandakanyeka ekugqithiseni amandla njengenxalenye ye-adenosine triphosphate (ATP), imali yokuqala yamandla eseli. Ukongeza kwindima yayo kwi-metabolism yamandla, i-adenosine iphinda isebenze njengemolekyuli yokubonisa, isebenza ngee-receptors ezithile emzimbeni.

Enye yezinto eziphambili ze-adenosine pharmacology yindlela yokusebenza kwayo. I-Adenosine isebenza ngokubophelela kwi-adenosine receptors ezithile, apho kukho iindidi ezine: A1, A2A, A2B, kunye ne-A3. I-isoform nganye inxulumene nemisebenzi eyahlukeneyo ye-physiological kunye neendlela zokubonisa. Xa i-adenosine ibophelela kwi-receptors yayo, ilawula iindidi zeenkqubo zeselula, kuquka i-neurotransmission, i-vascular tone, kunye nokusebenza komzimba. Ngokomzekelo, ukusetyenziswa kwe-A1 receptors kunokukhokelela ekuvimbeleni ukukhululwa kwe-neurotransmitter, ngelixa ukusetyenziswa kwe-A2A receptors kunokukhokelela kwi-vasodilation kunye nemiphumo echasayo.

Ukuqonda i-pharmacology ye-adenosine kukhokelela kwizicelo zeklinikhi kwiindawo ezahlukeneyo zonyango. Enye yezona zinto zisetyenziswa kakhulu kwikliniki ye-adenosine yindima yayo kunyango lwe-arrhythmias ethile yentliziyo. I-Adenosine isetyenziswa njenge-agent ye-antiarrhythmic ngenxa yokukwazi ukucotha ukuqhuba nge-atrioventricular node, ngaloo ndlela iphazamisa indlela yokubuya kunye nokubuyisela isigqi esiqhelekileyo se-sinus. Ukongezelela, i-adenosine isetyenziswe njenge-arhente yoxinzelelo lwe-pharmacological kwizifundo ze-imaging zenhliziyo ukuvavanya ukuchithwa kwe-myocardial.

Isishwankathelo, i-adenosine yi-molecule eneenkalo ezininzi kunye nokusetyenziswa kweklinikhi ezininzi ngenxa yeempawu zayo ze-pharmacological kunye nendlela yokusebenza. Ikhono layo lokulungelelanisa iinkqubo zeselula ngokusebenzisa i-receptors ethile yentsebenziswano yenza ukuba ibe sisixhobo esixabisekileyo ekuphatheni iimeko ezahlukeneyo zonyango, ukusuka kwi-cardiac arrhythmias ukuya kwizifo zokuphefumula kunye nokusetyenziswa kwe-neuroprotective. Njengoko uphando nge-adenosine luqhubeka, ukusetyenziswa okutsha kweklinikhi kule molekyuli inomdla kunokuqhubeka nokuvela, nokwandisa amandla ayo onyango kumayeza.

Nceda uqhagamshelane no-Alisa ngeenkcukacha ezithe kratyasales02@imaherb.com