Amandla Okuphulukisa we-N-Acetylcysteine weZimo Ezingamahlalakhona Zokuvuvukala
Izimo ezingapheli zokuvuvukala zingadambisa, zibangele ubuhlungu, ukungakhululeki, kanye nokwehla kwezinga lempilo kulabo abathintekile. Ukwelashwa kwendabuko kuvame ukugxila ekulawuleni izimpawu esikhundleni sokubhekana nembangela yokuvuvukala. Kodwa-ke, kukhona ucwaningo olukhulayo oluphakamisa ukuthi i-N-Acetylcysteine (NAC) powder ingase ibambe isihluthulelo sokuphatha ngisho nokuphulukisa izimo ezingapheli zokuvuvukala.
I-N-Acetylcysteine iyi-antioxidant enamandla futhi isandulela ku-glutathione, i-antioxidant enamandla ekhiqizwa ngokwemvelo emzimbeni. I-Glutathione idlala indima ebalulekile ekwehliseni ingcindezi ye-oxidative nasekulweni nokuvuvukala. Kodwa-ke, izimo ezithile zokuvuvukala okungapheli, njenge-rheumatoid arthritis kanye nesifo samathumbu esivuvukalayo, zinganciphisa amazinga e-glutathione omzimba, kubhebhethekise ukuvuvukala.
Ukwengeza nge-N-Acetylcysteine powder kubonise imiphumela ethembisayo ezifundweni ezihlukahlukene, okubonisa ukusebenza kwayo ekunciphiseni ukuvuvukala. Ucwaningo olushicilelwe kumagazini i-Free Radical Biology and Medicine luthole ukuthi i-NAC inganciphisa kakhulu izimpawu zokuvuvukala ezigulini ezine-rheumatoid arthritis. Olunye ucwaningo olwanyatheliswa kuyi-American Journal of Physiology-Gastrointestinal and Liver Physiology lubonise ukuthi i-NAC ingavikela ekuvuvukeni kwamathumbu emagundeni.
Enye yezindlela i-N-Acetylcysteine esebenzisa ngayo imiphumela yokulwa nokuvuvukala iwukuguqula umsebenzi we-nuclear factor-kappa B (NF-κB), iphrotheni eyinhloko ehilelekile ekulawuleni izakhi zofuzo ezifaka isandla ekuvuvukeni. I-NAC ivimbela i-NF-κB, ivimbela ukukhiqizwa kwama-molecule e-pro-inflammatory nokunciphisa ukuvuvukala okuphelele emzimbeni.
Ngaphezu kwalokho, i-N-Acetylcysteine inezinto ze-mucolytic, eziyenza iphumelele ekulawuleni izimo ezingapheli zokuphefumula ezifana nesifo se-chronic obstructive pulmonary disease (COPD) nesifo somoya. Ngokuphula kanye nokunciphisa amafinyila, i-NAC isiza ukuthuthukisa ukusebenza kwamaphaphu futhi inciphise izimpawu ezihlobene nalezi zimo.
Ngaphezu kwezakhiwo zayo zokulwa nokuvuvukala, i-N-Acetylcysteine ibonise amandla ekwelapheni izimo zempilo yengqondo ezihambisana nokuvuvukala. Ocwaningweni olushicilelwe ku- JAMA Psychiatry , abacwaningi bathola ukuthi ukwesekwa kwe-NAC kunciphisa izimpawu zokucindezeleka kubantu abane-bipolar disorder. Ucwaningo luphakamise ukuthi ikhono le-NAC lokushintsha i-glutamate, i-neurotransmitter ehilelekile ekucindezelekeni, lingase libe nomthelela emiphumeleni yalo yokusimamisa isimo sengqondo.
Nakuba i-N-Acetylcysteine powder ibonisa isithembiso esikhulu ekunciphiseni izimo ezivuthayo ezingapheli, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokuyifaka ohlelweni lwakho lokwelapha. Bangakunikeza isiqondiso ngomthamo ofanele futhi bakusize ukuqapha ukuqhubeka kwakho.
Kubalulekile ukuqaphela ukuthi nakuba i-NAC ngokuvamile iphephile, imithamo ephezulu kanye nokusetshenziswa isikhathi eside kungaholela emiphumeleni emibi efana nokungakhululeki emathunjini kanye nokungezwani nomzimba. Ukwengeza, abantu abane-asthma noma umlando wokuquleka kufanele baqaphe lapho becubungula ukwesekwa kwe-NAC.
Ekuphetheni, i-N-Acetylcysteine powder inamandla amakhulu ekulawuleni izimo ezingapheli zokuvuvukala. Ngokunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative kanye nokulinganisa amaprotheni abalulekile ahilelekile ekuphenduleni kokuvuvukala, i-NAC inganikeza impumuzo futhi ithuthukise inhlalakahle yonke yabantu abaphethwe yilezi zimo. Kodwa-ke, kubalulekile ukusebenzisana eduze nochwepheshe bezempilo ukuze uqinisekise ukusetshenziswa okuphephile nokusebenzayo kwe-N-Acetylcysteine powder njengengxenye yohlelo lwakho lokwelapha.
Incazelo Yomkhiqizo
I-N-acetyl cysteine (NAC) ivela ku-amino acid L-cysteine. Ama-amino acid ayizingqimba zokwakha amaprotheni. I-NAC inokusetshenziswa okuningi futhi iwumuthi ogunyazwe yi-FDA.
I-N-acetyl cysteine i-antioxidant engase ibambe iqhaza ekuvimbeleni umdlavuza. Njengomuthi, usetshenziswa abahlinzeki bezempilo ukwelapha ubuthi be-acetaminophen (Tylenol). Isebenza ngokubopha izinhlobo ezinobuthi ze-acetaminophen ezakheka esibindini.
Abantu bavame ukusebenzisa i-N-acetyl cysteine ukukhwehlela nezinye izimo zamaphaphu. Ibuye isetshenziselwe umkhuhlane, iso elomile, nezinye izimo eziningi, kodwa abukho ubufakazi obuhle besayensi obusekela okuningi kwalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-N-acetyl cysteine ye-COVID-19.
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
Umsebenzi
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
