Isayensi Engemuva kwe-N-Acetylcysteine: Indlela Esekela Ngayo Umsebenzi Wokuphefumula
I-N-Acetylcysteine powder, eyaziwa nangokuthi i-NAC, iyi-antioxidant enamandla futhi isandulela se-glutathione, i-molecule ebalulekile ekuvikelweni kwemizimba yethu ngokumelene nezinto ezinobuthi. Nakuba i-NAC isetshenziswe amashumi eminyaka njenge-ejenti ye-mucolytic, ucwaningo lwakamuva lukhanyise indima yalo ekusekeleni umsebenzi wokuphefumula. Kulesi sihloko, sizohlola isayensi ngemuva kwe-N-Acetylcysteine kanye nemiphumela yayo enenzuzo ohlelweni lokuphefumula.
Ukuze siqonde ukuthi i-N-Acetylcysteine isekela kanjani umsebenzi wokuphefumula, kufanele sihlole izindlela eziyisisekelo zempilo yokuphefumula. Isimiso sokuphefumula sihlanganisa imigudu yethu yokuphefumula, amaphaphu, kanye nenethiwekhi eyinkimbinkimbi yamaseli anesibopho sokushintshisana ngegesi. Kodwa-ke, ukuchayeka ezintweni ezingcolisayo, amagciwane, noma izimo ezithile zezokwelapha kungaholela ekucindezelekeni kwe-oxidative nokuvuvukala, kuphazamise umsebenzi wokuphefumula.
Kulapho i-N-Acetylcysteine ifakazela khona ukuthi ibalulekile. Njengesandulela se-glutathione, isebenza njenge-antioxidant enamandla, iqeda ama-radicals ayingozi futhi inciphisa ukucindezelwa kwe-oxidative. Ngokugcwalisa amazinga e-intracellular glutathione, i-N-Acetylcysteine isiza ukugcina ibhalansi ethambile yama-antioxidants futhi ivikela uhlelo lokuphefumula ekulimaleni.
Ngaphezu kwalokho, i-N-Acetylcysteine inezici ze-mucolytic, okusho ukuthi isiza ukudiliza kanye namafinyila amancane emigwaqweni yomoya. Lokhu kuzuzisa kakhulu kubantu abanezimo zokuphefumula ezingamahlalakhona, njenge-Cronic obstructive pulmonary disease (COPD) noma i-cystic fibrosis, lapho ukukhiqizwa kwamafinyila okweqile kanye nokuvunyelwa okungalungile kungavimba imigudu yokuphefumula. Ngokukhuthaza ukucaciswa kwe-mucus, i-N-Acetylcysteine ithuthukisa ukusebenza kwamaphaphu futhi inciphisa ingozi yezinkinga zokuphefumula.
Ucwaningo oluningana lwesayensi luye lwaqinisekisa imiphumela enenzuzo ye-N-Acetylcysteine empilweni yokuphefumula. Isibonelo, ucwaningo olwanyatheliswa kuyi-European Respiratory Journal lubonise ukuthi i-N-Acetylcysteine supplementation yenza ngcono ukusebenza kwamaphaphu futhi yanciphisa ukukhushulwa kokuphefumula kubantu abaneCOPD. Olunye ucwaningo olwanyatheliswa kuyi-American Journal of Respiratory and Critical Care Medicine lwathola ukuthi i-N-Acetylcysteine yanciphisa imvamisa nokuqina kokuhlaselwa yi-asthma ezinganeni.
Ngaphandle kwezakhiwo zayo ze-antioxidant kanye ne-mucolytic, i-N-Acetylcysteine ibuye ibonise imiphumela yokulwa nokuvuvukala. Ukuvuvukala kuwuphawu lwezifo zokuphefumula, njengoba kunomthelela ekuvinjweni komoya kanye nokulimala kwezicubu. I-N-Acetylcysteine isiza ukulawula ukukhululwa kwama-molecule e-pro-inflammatory, njengama-cytokines, futhi iguqule impendulo yomzimba. Ngokunciphisa i-cascade yokuvuvukala, i-N-Acetylcysteine yehlisa izimpawu zokuphefumula futhi ikhuthaze ukululama.
Kuyaqapheleka ukuthi i-N-Acetylcysteine ngokuvamile iphephile futhi ibekezelelwa kahle, inemiphumela emibi emincane. Kodwa-ke, njenganoma yisiphi isithasiselo, kuyatuseka ukuthintana nochwepheshe bezempilo ngaphambi kokuqala i-N-Acetylcysteine supplementation, ikakhulukazi kubantu abanezimo zezokwelapha ezingaphansi noma labo abaphuza imithi.
Sengiphetha, i-N-Acetylcysteine powder iyisengezo esinamandla esinikeza izinzuzo eziningi zempilo yokuphefumula. I-antioxidant, i-mucolytic, ne-anti-inflammatory properties isebenza ngokubambisana ukuze isekele uhlelo lokuphefumula futhi inciphise umonakalo obangelwa ukucindezeleka okwenziwe nge-oxidative nokuvuvukala. Nakuba ucwaningo olwengeziwe ludingeka ukuze kuqondwe ngokugcwele izinga lamandla ayo okwelapha, i-N-Acetylcysteine inesithembiso njengesengezo semvelo nesisebenzayo ekulawuleni izimo ezihlukahlukene zokuphefumula.
Incazelo Yomkhiqizo
I-N-acetyl cysteine (NAC) ivela ku-amino acid L-cysteine. Ama-amino acid ayizingqimba zokwakha amaprotheni. I-NAC inokusetshenziswa okuningi futhi iwumuthi ogunyazwe yi-FDA.
I-N-acetyl cysteine i-antioxidant engase ibambe iqhaza ekuvimbeleni umdlavuza. Njengomuthi, usetshenziswa abahlinzeki bezempilo ukwelapha ubuthi be-acetaminophen (Tylenol). Isebenza ngokubopha izinhlobo ezinobuthi ze-acetaminophen ezakheka esibindini.
Abantu bavame ukusebenzisa i-N-acetyl cysteine ukukhwehlela nezinye izimo zamaphaphu. Ibuye isetshenziselwe umkhuhlane, iso elomile, nezinye izimo eziningi, kodwa abukho ubufakazi obuhle besayensi obusekela okuningi kwalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-N-acetyl cysteine ye-COVID-19.
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
Umsebenzi
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
