Zitholele Isayensi Engemuva kwe-Kojic Acid Dipalmitate kanye Nezinzuzo zayo Zesikhumba
Zitholele Isayensi Engemuva kwe-Kojic Acid Dipalmitate kanye Nezinzuzo zayo Zesikhumba
I-Aogubio, inkampani ekhethekile ekukhiqizweni nasekusabalaliseni izinto ezisebenza ekhemisi, izinto ezingavuthiwe, okukhishwe kwezitshalo, kanye nokudla okunomsoco, inikeza uhla lwemikhiqizo esezingeni eliphezulu yezimboni zemithi, zokudla, ezokudla okunomsoco, nezimonyo. Omunye wemikhiqizo yabo ephawulekayo yi-kojic acid dipalmitate, eyaziwa kabanzi ngokusebenza kwayo ekunakekeleni isikhumba kanye nezinzuzo.
I-Kojic acid dipalmitate iyinhlanganisela yamakhemikhali evame ukusetshenziswa kuzimonyo ngenxa yezakhiwo zayo eziphawulekayo njengesikhilimu selanga kanye ne-antioxidant. Ngokungafani nezinye izithako zokunakekela isikhumba, i-kojic acid dipalmitate iphephile ukuthi isetshenziswe ekugxilweni okuphansi futhi ayinayo imiphumela emibi ebalulekile. Kodwa-ke, kufanelekile ukuqaphela ukuthi ukugxila okuphezulu kwalesi sakhi kungabangela ukucasuka kwesikhumba noma ukungezwani komzimba. Ngakho-ke, abantu abanesikhumba esibucayi bayelulekwa ukuthi benze ukuhlolwa kwesikhumba ngaphambi kokufaka imikhiqizo equkethe i-kojic acid dipalmitate ohlelweni lwabo.
Kususelwa ku-kojic acid, i-kojic acid dipalmitate ibonakala njengamakristalu amhlophe noma angekho mhlophe futhi ithathwa kakhulu njenge-ejenti yokwenza mhlophe esebenza kahle. Isebenza ngokuvimbela umsebenzi we-tyrosinase, i-enzyme eyinhloko ehilelekile ekukhiqizeni i-melanin. Lokhu kusho ukuthi i-kojic acid dipalmitate ingavimba ngempumelelo noma ibambezele ukwakheka kwe-melanin, ekugcineni kuholele ebaleni elikhanyayo nelikhudlwana. Izakhiwo zayo ezimhlophe zihlolisiswe kabanzi futhi zaqinisekiswa umkhakha wezokwelapha, bathola ukuqashelwa kuMnyango Wezempilo.
Okwenza i-kojic acid i-dipalmitate ihluke ngokukhethekile ukuzinza kwayo okuphezulu, okudlula lokho kukavithamini C. Nakuba uvithamini C waziwa ngomphumela wawo wokulwa ne-antioxidant kanye nezindawo ezikhanyisa isikhumba, angase angazinzi futhi athambekele ekubeni ne-oxidation. I-Kojic acid dipalmitate, ngakolunye uhlangothi, igcina ukuzinza nokusebenza kwayo ngokuhamba kwesikhathi. Lokhu kuzinza kuvumela ukuthi ingene ijule esikhunjeni futhi imunceke kalula, ekugcineni ithambise i-stratum corneum futhi ithuthukise ukuthungwa kwesikhumba.
Ngaphezu kwezakhiwo zayo ezimhlophe kanye ne-antioxidant, i-kojic acid dipalmitate isetshenziswe kakhulu emkhakheni wezokwelapha ukuze kukhanye amabala obuso. Ikhono layo lokunciphisa ukubukeka kwe-hyperpigmentation liyenze yaba isithako esifunwayo ekwenziweni okuhlukahlukene kwezimonyo. Abantu abaningi baye babika imiphumela emihle, ngokuncipha okuphawulekayo kwamabala amnyama kanye nokuthuthuka okuphelele kwethoni yesikhumba.
Nakuba i-kojic acid dipalmitate ingabangeli ngokuqondile induna, kubalulekile ukucabangela ukuhambisana kwayo nezinye izithako. Ezinye izinhlanganisela zingandisa ingozi yokuthuthukiswa kwezinduna. Kulabo abajwayele ukuqubuka noma abanesikhumba esinezinduna, kuyatuseka ukuthi uthintane nodokotela wesikhumba noma wenze ukuhlolwa kwe-patch ukuze uhlole ukuthi isikhumba sabo sisabela kanjani emikhiqizweni equkethe i-kojic acid dipalmitate.
Sengiphetha, isayensi ngemuva kwe-kojic acid dipalmitate iveza amandla ayo okuba isithako esinamandla sezimonyo. Ngokufaka mhlophe kwayo, i-antioxidant, kanye nezindawo ezikhanyisa isikhumba, le nhlanganisela inikeza isisombululo esiphephile nesisebenzayo kubantu abafuna ukuthuthukisa ukubukeka kwesikhumba sabo. Ukuzibophezela kuka-Aogubio ekukhiqizeni imikhiqizo yekhwalithi ephezulu kuqinisekisa ukuthi abathengi bathola izinzuzo ezigcwele ze-kojic acid dipalmitate, kuyilapho kucatshangelwa imiphumela engemihle engaba khona kanye nokuhambisana nezinhlobo ezahlukene zesikhumba.
Incazelo Yemikhiqizo
I-Kojic acid dipalmitate i-modified kojic acid derivative, engagcini nje ngokunqoba ukuntengantenga kokukhanya, ukushisa kanye ne-iron eyinsimbi, kodwa futhi igcina umsebenzi ovimbelayo we-tyrosinase futhi ivimbele ukwakheka kwe-melanin. I-Kojic dipalmitate ingumnikazi wendawo yamakhemikhali ezinzile. Ngeke ijike ibe phuzi uma isetshenziselwa i-oxidation, i-metallic ion, ukukhanya nokushisa.
Umsebenzi
- i-kojic acid dipalmitate iwuhlobo lwesivimbeli esikhethekile se-melanin. Ingavimbela umsebenzi we-tyrosinase ngokuhlanganiswa ne-ion yethusi kumaseli ngemva kokungena kumaseli esikhumba. I-Kojic acid nokuphuma kwayo kunomphumela ongcono wokuvimbela i-tyrosinase kunanoma iyiphi enye i-ejenti emhlophe yesikhumba.
- I-kojic acid dipalmitate ingaphinda iqede i-radical yamahhala, iqinise ukusebenza kwamaseli futhi igcine ukudla kukusha.
UKUHLAZIYWA OKUSISEKELO
| UHLAZIYO | INKCAZO | IMIPHUMELA |
| Ukubukeka | Impushana Emhlophe | Iyahambisana |
| Iphunga | Isici | Iyahambisana |
| Kunambithile | Isici | Iyahambisana |
| Isivivinyo | 99% | Iyahambisana |
| Sieve Analysis | I-100% idlula i-80 mesh | Iyahambisana |
| Ukulahlekelwa Ekumisweni | 5% Ubukhulu. | 1.02% |
| Umlotha one-sulphate | 5% Ubukhulu. | 1.3% |
| Khipha i-Solvent | I-Ethanol Namanzi | Iyahambisana |
| Insimbi Enzima | 5 ppm Max | Iyahambisana |
| Njengoba | 2ppm Max | Iyahambisana |
| Izincibilikisi Ezisele | 0.05% Ubukhulu. | Okubi |
| I-Microbiology | ||
| Inani Lepuleti Eliphelele | 1000/g Ubukhulu | Iyahambisana |
| Imvubelo & Isikhunta | 100/g Ubukhulu | Iyahambisana |
| E.Coli | Okubi | Iyahambisana |
| I-Salmonella | Okubi | Iyahambisana |
Izinhlelo zokusebenza
Ama-toner okunakekela umzimba/ubuso, izinto zokulwa nokuguga, ukuvikela ilanga, ngemva kokushona kwelanga nokuzishuka, ukucwenga kwesikhumba/ukukhanya, ukwelapha izimo ezihlukahlukene zesikhumba ezishintsha umbala obala noma iziyaluyalu, isb ama-solar lentigene, i-melasma, i-chloasma, izibazi, amabala, ubudala be-pigment nezinye izindawo zesikhumba ezinombala ogqamile
