Iqhaza le-N-Acetylcysteine Ekusekeleni Umsebenzi Wamaphaphu Kwababhemayo
Ukubhema kuwumkhuba ovamile obeka engcupheni enkulu yezempilo, ikakhulukazi ethinta ukusebenza kwamaphaphu. Amakhemikhali ayingozi akhona entuthwini kagwayi angabangela ukuvuvukala, ukucindezeleka kwe-oxidative, nokulimala ohlelweni lokuphefumula. Ngenxa yalokho, ababhemayo ngokuvamile baba nokuncipha kwamandla amaphaphu, izimpawu zokuphefumula, kanye nokungenwa kalula kwezifo zokuphefumula. Kodwa-ke, ucwaningo lwamuva luye lwabonisa ukuthi ama-capsules we-N-Acetylcysteine (NAC) noma i-powder angase adlale indima ebalulekile ekusekeleni umsebenzi wamaphaphu kwababhemayo.
I-N-Acetylcysteine iwuhlobo oluguquliwe lwe-amino acid cysteine futhi isebenza njengesandulela se-glutathione, i-antioxidant enamandla. I-Glutathione ikhiqizwa ngokwemvelo emzimbeni futhi idlala indima ebalulekile ekuvikeleni amaseli emonakalweni we-oxidative. Kodwa-ke, ukubhema kuqeda amazinga e-glutathione, okuholela ekukhuleni kwengcindezi ye-oxidative nokuvuvukala emaphashini. Ngokufaka i-N-Acetylcysteine, ababhemayo bangakwazi ukugcwalisa amazinga e-glutathione futhi banciphise imiphumela eyingozi yokubhema empilweni yamaphaphu.
Enye inzuzo eyinhloko ye-N-Acetylcysteine amandla ayo okuphula amafinyila emigwaqweni yomoya. Ukubhema kungabangela ukukhiqizwa kwamafinyila ngokweqile, okuholela ekuminyaniseni nasekungasebenzi kahle kwamaphaphu. I-NAC isebenza ngokunciphisa amafinyila, okwenza kube lula ukuwakhipha. Le mpahla ye-N-Acetylcysteine ingasiza ababhemayo ukuthi bahlanze imigudu yabo yokuphefumula, banciphise ingozi yezifo zokuphefumula, futhi bathuthukise ukusebenza kwamaphaphu kukonke.
Ngaphezu kwalokho, i-N-Acetylcysteine ibonise izakhiwo zokulwa nokuvuvukala. Ukuvuvukala okubangelwa ukubhema emaphashini kungabangela ukulimala kwezicubu kanye nokuthuthukiswa kwezifo ezihlukahlukene zokuphefumula, njengezifo ezingapheli ze-pulmonary pulmonary (COPD). Ucwaningo luye lwabonisa ukuthi i-NAC ingasiza ekunciphiseni ukuvuvukala emaphashini ngokuvimbela ukukhiqizwa kwama-molecule e-pro-inflammatory. Ngokunciphisa ukuvuvukala, i-N-Acetylcysteine ingase ibambezele ukuqhubeka kwezifo zamaphaphu ezihlobene nokubhema futhi inciphise izimpawu ezihlobene nezimo zokuphefumula.
Esinye isici esibalulekile okufanele sicatshangelwe amandla e-N-Acetylcysteine ukuvikela emonakalweni we-oxidative. Ukubhema kuholela esizukulwaneni sama-radicals mahhala ayingozi emzimbeni, angadala ingcindezi ye-oxidative. Lokhu kucindezeleka kwe-oxidative kulimaza izakhiwo zamangqamuzana futhi kunomthelela ekwakhiweni kwezifo zamaphaphu. Ukwengezwa kwe-NAC kungasiza ekunciphiseni la ma-radicals mahhala futhi kunciphise umthwalo wengcindezi ye-oxidative emaphashini, ngaleyo ndlela kusekele ukusebenza kwamaphaphu futhi kunciphise ingozi yezinkinga ezihlobene nokubhema.
Kuyaphawuleka ukuthi ucwaningo olwengeziwe lusadingeka ukuze uqonde ngokugcwele izinzuzo ze-N-Acetylcysteine ekusekeleni ukusebenza kwamaphaphu kwababhemayo. Nakuba ubufakazi bamanje buyathembisa, ucwaningo olwengeziwe luyadingeka ukuze kutholwe umthamo ophelele, ubude besikhathi, kanye nemiphumela yesikhathi eside ye-NAC supplementation. Ukwengeza, abantu kufanele bathintane nabahlinzeki babo bezempilo ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwelapha entsha, ikakhulukazi uma benezimo zezokwelapha ezivele zikhona noma bephuza eminye imithi.
Ekuphetheni, ama-capsules we-N-Acetylcysteine noma i-powder angase anikeze izinzuzo ezibalulekile ekusekeleni umsebenzi wamaphaphu kwababhemayo. Ngokugcwalisa amazinga e-glutathione, ukunciphisa amafinyila, ukunciphisa ukuvuvukala, nokuvikela emonakalweni we-oxidative, i-NAC ingase inciphise imiphumela eyingozi yokubhema ohlelweni lokuphefumula. Noma kunjalo, kubalulekile ukuqhubeka uhlola lesi sihloko ngocwaningo futhi uxhumane nochwepheshe bezokunakekelwa kwezempilo ukuze uthole iseluleko esiqondene nawe. Ekugcineni, ukuyeka ukubhema kuseyisu elingcono kakhulu lokuthuthukisa ukusebenza kwamaphaphu kanye nempilo yonke.
Incazelo Yomkhiqizo
I-N-acetyl cysteine (NAC) ivela ku-amino acid L-cysteine. Ama-amino acid ayizingqimba zokwakha amaprotheni. I-NAC inokusetshenziswa okuningi futhi iwumuthi ogunyazwe yi-FDA.
I-N-acetyl cysteine i-antioxidant engase ibambe iqhaza ekuvimbeleni umdlavuza. Njengomuthi, usetshenziswa abahlinzeki bezempilo ukwelapha ubuthi be-acetaminophen (Tylenol). Isebenza ngokubopha izinhlobo ezinobuthi ze-acetaminophen ezakheka esibindini.
Abantu bavame ukusebenzisa i-N-acetyl cysteine ukukhwehlela nezinye izimo zamaphaphu. Ibuye isetshenziselwe umkhuhlane, iso elomile, nezinye izimo eziningi, kodwa abukho ubufakazi obuhle besayensi obusekela okuningi kwalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-N-acetyl cysteine ye-COVID-19.
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
Umsebenzi
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
