Isixhumanisi Phakathi Kwe-N-Acetylcysteine kanye Nomsebenzi Wokuqonda Othuthukisiwe
I-N-Acetylcysteine (NAC) iyi-antioxidant enamandla futhi ingumanduleli we-glutathione, okungenye ye-antioxidant ebaluleke kakhulu yomzimba. Nakuba ngokuyinhloko isetshenziswa njenge-ejenti ye-mucolytic yokwelapha izimo zokuphefumula, ucwaningo lwakamuva lubonise ukuthi i-NAC nayo inezinzuzo ezingaba khona ekusebenzeni kwengqondo.
Umsebenzi wokuqonda uhlanganisa izinqubo zengqondo ezihlukahlukene, okuhlanganisa ukunaka, inkumbulo, namakhono okuxazulula izinkinga. Njengoba sikhula, ukwehla kwengqondo kuya ngokuya kuvame, okuholela ezimweni ezinjengokuwohloka komqondo kanye nesifo i-Alzheimer's. Ngakho-ke, ukuthola izindlela zokuthuthukisa nokugcina ukusebenza kwengqondo kuyisihloko esithakaselwa kakhulu abacwaningi kanye nomphakathi jikelele ngokufanayo.
Ucwaningo oluningana luphenye ukuxhumana phakathi kwe-NAC nokusebenza kwengqondo okuthuthukisiwe, okuhlinzeka ngemiphumela ethembisayo. Olunye ucwaningo olwanyatheliswa kuyi-Journal of Clinical Psychopharmacology lwahlola imiphumela ye-NAC kubahlanganyeli abangu-140 abane-bipolar disorder. Abacwaningi bathole ukuthi i-NAC ithuthukise kakhulu ukusebenza okuphezulu, inkumbulo yokusebenza, nokusebenza kwengqondo okuphelele kulaba bantu.
Olunye ucwaningo olwenziwa eNyuvesi yase-Utah lwahlola imiphumela ye-NAC kubantu abadala abanempilo. Abahlanganyeli bahlukaniswe ngamaqembu amabili, iqembu elilodwa elithola i-NAC kanti elinye lithola i-placebo. Ngemva kwamasonto amane, labo abathatha i-NAC babonise ukuthuthuka okuphawulekayo kwinkumbulo yokusebenza nokunaka uma kuqhathaniswa neqembu le-placebo.
Indlela ebangela umthelela omuhle we-NAC ekusebenzeni kwengqondo ayikaqondwa ngokugcwele. Kodwa-ke, abacwaningi bakholelwa ukuthi kungase kube ngenxa yezakhiwo zayo ze-antioxidant kanye nekhono layo lokubuyisela ibhalansi yama-neurotransmitters ebuchosheni. Ngokunciphisa ukucindezeleka kwe-oxidative nokuthuthukisa ukusebenza kwe-neurotransmitter, i-NAC ingasiza ukuvikela amangqamuzana obuchopho futhi ithuthukise izinqubo zokuqonda.
Ngaphezu kwalokho, i-NAC iphinde yabonisa amandla okuthuthukisa ukusebenza kwengqondo kubantu abathile. Ngokwesibonelo, kuye kwahlolisiswa kubantu abane-schizophrenia, ukuphazamiseka kwengqondo ngokuvamile okuthinta amakhono okuqonda. Ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta okushicilelwe ku-Journal of Clinical Psychopharmacology kuphethe ngokuthi ukwesekwa kwe-NAC kuholele ekuthuthukisweni okuphawulekayo ekusebenzeni kwengqondo kubantu abane-schizophrenia.
Ngokungeziwe emiphumeleni yayo eqondile ekusebenzeni kwengqondo, i-NAC ingase futhi ithuthukise imiphumela yengqondo ngokungaqondile ngokukhomba izimo ezingaphansi. Isibonelo, isetshenziswe njenge-adjunct therapy ekwelapheni ukuphazamiseka kwezidakamizwa. Ngokunciphisa izifiso nokuvimbela ukuziphatha okuluthayo, i-NAC ingasiza abantu ngabanye ukuba baphinde balawule izimpilo zabo, okuholela ekusebenzeni okuthuthukisiwe kwengqondo.
Uma ucabangela ukusebenzisa i-NAC ukuze uthuthukise ingqondo, kubalulekile ukuthintana nochwepheshe bezokunakekelwa kwempilo. Nakuba ngokuvamile ibhekwa njengephephile, i-NAC ingase ihlanganyele nemithi ethile noma ibe nemiphumela engemihle kwabanye abantu. Ukwengeza, umthamo ophelele kanye nobude besikhathi sokwengeza kungahluka kuye ngezidingo nezimo zomuntu ngamunye.
Sengiphetha, ucwaningo olusafufusa lubonisa ukuthi i-N-Acetylcysteine ingaba nezinzuzo ezingaba khona zokuthuthukisa umsebenzi wokuqonda. Izakhiwo zayo ze-antioxidant kanye nekhono lokushintsha ama-neurotransmitters ebuchosheni kungase kube nomthelela kule miphumela emihle. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kuqondwe ngokugcwele izindlela eziqondile kanye nezinzuzo ezingaba khona zokungezelelwa kwe-NAC. Uma ungathanda ukusebenzisa i-NAC ukuze uthuthukise amakhono akho okuqonda, kuhlale kuhle ukuthi uxhumane nochwepheshe bezempilo kuqala ukuze uqinisekise ukuthi iyakufanelekela.
Incazelo Yomkhiqizo
I-N-acetyl cysteine (NAC) ivela ku-amino acid L-cysteine. Ama-amino acid ayizingqimba zokwakha amaprotheni. I-NAC inokusetshenziswa okuningi futhi iwumuthi ogunyazwe yi-FDA.
I-N-acetyl cysteine i-antioxidant engase ibambe iqhaza ekuvimbeleni umdlavuza. Njengomuthi, usetshenziswa abahlinzeki bezempilo ukwelapha ubuthi be-acetaminophen (Tylenol). Isebenza ngokubopha izinhlobo ezinobuthi ze-acetaminophen ezakheka esibindini.
Abantu bavame ukusebenzisa i-N-acetyl cysteine ukukhwehlela nezinye izimo zamaphaphu. Ibuye isetshenziselwe umkhuhlane, iso elomile, nezinye izimo eziningi, kodwa abukho ubufakazi obuhle besayensi obusekela okuningi kwalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-N-acetyl cysteine ye-COVID-19.
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
Umsebenzi
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
