Ikhonkco phakathi kwe-N-Acetylcysteine kunye noMsebenzi oPhuculweyo weNgcaciso yoMfanekiso

Ikhonkco phakathi kwe-N-Acetylcysteine kunye nomsebenzi ophuculweyo wokuqonda

Igama lemveliso:N-Acetylcysteine

Imbonakalo:Umgubo wekristale omhlophe

Yabelana ku:

Buza I-COA / MADS

Iinkcukacha zeMveliso

Ukuthumela ngenqanawa kunye nokuPakisha

Inkonzo ye-OEM

Ngathi

Iithegi zeMveliso

I-N-Acetylcysteine (NAC) yi-antioxidant enamandla kunye ne-precursor ye-glutathione, enye yezona antioxidants ezibalulekileyo zomzimba. Nangona ngokuyintloko isetyenziswa njenge-agent ye-mucolytic ukunyanga iimeko zokuphefumla, uphando lwakutsha nje lubonise ukuba i-NAC nayo ineenzuzo ezinokubakho ekusebenzeni kwengqondo.

Umsebenzi wokuqonda ubandakanya iinkqubo ezahlukeneyo zengqondo, kubandakanya ingqwalasela, inkumbulo, kunye nesakhono sokusombulula iingxaki. Njengoko sikhula, ukuncipha kwengqondo kuya kuxhaphaka, okukhokelela kwiimeko ezifana nesifo sengqondo esiyingozi kunye nesifo sika-Alzheimer. Ke ngoko, ukufumana iindlela zokuphucula kunye nokugcina umsebenzi wokuqonda sisihloko esinomdla kakhulu kubaphandi kunye nabemi ngokubanzi ngokufanayo.

Izifundo ezininzi ziye zaphanda ikhonkco phakathi kwe-NAC kunye nokuphuculwa komsebenzi wokuqonda, ukubonelela ngeziphumo ezithembisayo. Olunye uphando olupapashwe kwi-Journal ye-Clinical Psychopharmacology luhlolisise iziphumo ze-NAC kubathathi-nxaxheba be-140 abane-bipolar disorder. Abaphandi bafumanise ukuba i-NAC iphucule kakhulu ukusebenza kwesigqeba, inkumbulo yokusebenza, kunye nokusebenza kwengqondo ngokubanzi kwaba bantu.

Olunye uphando oluqhutywe kwiYunivesithi yase-Utah luhlolisise imiphumo ye-NAC kubantu abadala abasempilweni. Abathathi-nxaxheba bohlulwe bangamaqela amabini, elinye iqela lafumana i-NAC kwaye elinye lafumana i-placebo. Emva kweeveki ezine, abo bathatha i-NAC babonise ukuphuculwa okuphawulekayo kwimemori yokusebenza kunye nengqalelo xa kuthelekiswa neqela le-placebo.

Indlela esemva kwempembelelo entle ye-NAC ekusebenzeni kwengqondo ayikaqondwa ngokupheleleyo. Nangona kunjalo, abaphandi bakholelwa ukuba kungenxa yeempawu zayo ze-antioxidant kunye nokukwazi kwayo ukubuyisela ibhalansi ye-neurotransmitters kwingqondo. Ngokunciphisa uxinzelelo lwe-oxidative kunye nokuphucula ukusebenza kwe-neurotransmitter, i-NAC inokunceda ukukhusela iiseli zengqondo kunye nokuphucula iinkqubo zokuqonda.

Ngaphaya koko, i-NAC ikwabonise amandla okuphucula ukusebenza kwengqondo kubantu abathile. Ngokomzekelo, kuye kwafundwa kubantu abane-schizophrenia, ukuphazamiseka kwengqondo okuhlala kuchaphazela amandla okuqonda. Uphononongo olucwangcisiweyo kunye nohlalutyo lwe-meta olupapashwe kwi-Journal ye-Clinical Psychopharmacology yagqiba ukuba ukuxhaswa kwe-NAC kukhokelele ekuphuculeni okubonakalayo ekusebenzeni kwengqondo kubantu abane-schizophrenia.

Ukongeza kwiziphumo zayo ezithe ngqo ekusebenzeni kwengqondo, i-NAC inokuphucula ngokungathanga ngqo iziphumo zokuqonda ngokujolisa kwiimeko eziphantsi. Ngokomzekelo, isetyenziswe njengonyango oluncedisayo ekuphatheni ukuphazamiseka kweziyobisi. Ngokunciphisa iminqweno kunye nokuthintela indlela yokuziphatha ekhobokisayo, i-NAC inokunceda abantu baphinde balawule ubomi babo, nto leyo ekhokelela kuphuculo lokusebenza kwengqondo.

Xa ucinga ukusebenzisa i-NAC kuphuculo lwengqondo, kubalulekile ukubonisana nengcali yezempilo. Ngelixa ngokubanzi ithathwa njengekhuselekile, i-NAC inokunxibelelana namayeza athile okanye ibe neziphumo ebezingalindelekanga kwabanye abantu. Ukongezelela, idosi efanelekileyo kunye nobude bexesha lokuncedisa lunokwahluka ngokuxhomekeke kwiimfuno kunye neemeko zomntu ngamnye.

Ekugqibeleni, uphando olusakhulayo lubonisa ukuba i-N-Acetylcysteine ingaba neenzuzo ezinokuthi ziphucule umsebenzi wokuqonda. Iimpawu zayo ze-antioxidant kunye nokukwazi ukumodareyitha i-neurotransmitters kwingqondo kunokuba negalelo kule miphumo emihle. Nangona kunjalo, uphando olongezelelweyo luyafuneka ukuze kuqondwe ngokupheleleyo iindlela ezichanekileyo kunye neenzuzo ezinokubakho zokuxhaswa kwe-NAC. Ukuba unomdla wokusebenzisa i-NAC ukukhulisa amandla akho okuqonda, kusoloko kucetyiswa ukuba udibane nengcali yezempilo kuqala ukuze uqinisekise ukukufanelekela kwayo.

Ingcaciso yeMveliso

I-N-acetyl cysteine (NAC) ivela kwi-amino acid L-cysteine. Ii-amino acids ziibhloko zokwakha zeeproteni. I-NAC inosetyenziso oluninzi kwaye ilichiza elivunywe yi-FDA.

I-N-acetyl cysteine yi-antioxidant enokuthi idlale indima ekuthinteleni umhlaza. Njengechiza, lisetyenziswa ngababoneleli bezempilo ukunyanga i-acetaminophen (Tylenol) ityhefu. Isebenza ngokubophelela iintlobo ezinetyhefu ze-acetaminophen ezenziwe esibindini.

Abantu ngokuqhelekileyo basebenzisa i-N-acetyl cysteine ukukhohlela kunye nezinye iimeko zemiphunga. Ikwasetyenziselwa umkhuhlane, iliso elomileyo, kunye nezinye iimeko ezininzi, kodwa abukho ubungqina obulungileyo bezenzululwazi bokuxhasa uninzi lwezi zinto zisetyenziswayo. Akukho bungqina bulungileyo bokuxhasa ukusebenzisa i-N-acetyl cysteine ye-COVID-19.

I-N-Acetyl-L-Cysteine i-amino acid, inokuguqulwa emzimbeni we-methionine, i-cystine inokuguqulwa kunye nomnye. I-N-Acetyl-l-cysteine inokusetyenziswa njenge-agent ye-mucilagenic. Ifanelekile ukuthintela ukuphefumla okubangelwa ubuninzi bokuphazamiseka kwe-phlegm. Ukongeza, ingasetyenziselwa ukukhutshwa kwetyhefu ye-acetaminophen.