40% y'amazi ashonga acide azelaic

Ukurikije ibipimo ngenderwaho by’ibiyobyabwenge bya FDA, aside ya azelaic ni iy'umuti wo mu rwego rwa B, ushobora gukoreshwa neza mu gihe cyo gutwita no konsa. Irashobora kubuza umusaruro n’ibikorwa by’ubwoko bwa ogisijeni ikora, ifasha kurwanya anti-inflammatory ndetse nubuvuzi butandukanye ingaruka zibiyobyabwenge. Mugabanye synthesis ya keratine filamentous, irashobora kugabanya keratinisation ikabije yimisatsi kandi ikagira uruhu rwiza kuruhu.
Irashobora guteza imbere kwinjiza ibicuruzwa kuruhu wongeyeho aside ya azelaque mumavuta yo kwisiga. Byongeye kandi, aside ya azelaic irashobora kubuza bagiteri no kugenga ururenda rusanzwe rwa sebum, ariko guhuza kwayo kugarukira cyane kubera inenge ebyiri zisanzwe ziterwa no kutagira amazi meza hamwe no gushonga cyane.Urwego rwa testosterone ya androgene mumubiri ni ndende cyane, kandi iranyura Imyaka 5 muri glande ya sebaceous- α Igikorwa cya reductase gihinduka dihydrotestosterone, biganisha kumikorere mibi ya glande sebaceous, bikavamo gusohora amavuta menshi. Acide ya Azelaic irashobora guhagarika irushanwa 5- α Igikorwa cya reductase kibuza ihinduka rya androgene ikabije muri dihydrotestosterone, kandi amaherezo ikabuza gusohora gukabije kwa aside irike yubusa muri glande sebaceous.
Irashobora guhagarika umusaruro wa okisijeni yubusa ya radicals kandi ikagira uruhare mukurwanya inflammatory. Hydroxylation yimyunyu ngugu iterwa nitsinda rya ogisijeni ikora hamwe na peroxidisation ya acide arachidonic yabujijwe muri vitro.
Amazi 40% acide azelaic acide yakozwe na Shandong Binzhou Zhiyuan Biotechnology Co., Ltd ifite ibintu byinshi kandi yongewemo bike mubicuruzwa byita kuruhu. Ku bushyuhe bwicyumba, bishyirwa mumazi kugirango bikangure kandi bishonga, kandi igisubizo cyamazi kirasobanutse kandi kiboneye.
Keratose ikabije yimiyoboro ya sebaceous mumisatsi yumusatsi izahagarika umusatsi, mugihe acide azelaic igira ingaruka zo kurwanya keratotic kuruhu rusanzwe hamwe nuruhu rwanduye acne, rushobora kugabanya synthesis ya keratine yuzuye kandi ikarinda keratose ikabije yimisatsi.