Benfotiamine bụ ihe mgbakwunye nri nke agbanwere n'ime ahụ ka ọ bụrụ thiamine (vitamin B1). Thiamine na-enyere ahụ gị aka ịtụgharị nri nri ka ọ bụrụ ume ma dị mkpa maka ịrụ ọrụ ụbụrụ. Ụfọdụ ndị mmadụ na-eji benfotiamine na-ebuli ọkwa thiamine n'ihi na a na-ewere ya dị ka ihe dị ndụ nke ukwuu. Nke a pụtara na ọ na-eru n'ọbara ngwa ngwa ma na-emepụta thiamine dị elu n'ime ahụ.
N'ihi na o nwere antioxidant na mgbochi mkpali Njirimara, benfotiamine nwekwara ike na-enye aka maka ọrịa shuga neuropathy (mgbu akwara) na ọrịa Alzheimer.
Uru ahụike nke benfotiamine
1. Ọrịa mamịrị neuropathy
Usoro ọgwụgwọ Benfotiamine yiri ka ọ bụ atụmatụ nwere ike igbochi ọrịa shuga nephropathy, mgbagha siri ike nke ọrịa shuga, jikọtara ya na nnukwu ihe ize ndụ nke ọrịa obi na ịnwụ anwụ. Mmụba glucose dị elu na-eduga na mkpokọta triosephosphates; nke a na-eduga n'ịrụ ọrụ biochemical na n'ikpeazụ mmepe nke nephropathy mamịrị.
Ọmụmụ ihe izizi na oke egosila na benfotiamine na-egbochi mkpokọta triosephosphates na ọrịa shuga wee gbochie mmepe nke nephropathy.
2. Ọganihu ọgụgụ isi na ọrịa Alzheimer
Ọmụmụ ihe ọmụmụ egosila na benfotiamine na-enye mmetụta bara uru na nkwarụ ọgụgụ isi na ọrịa Alzheimer. E gosiputara Benfotiamine iji belata ntinye amyloid na ụdị anụmanụ nke ọrịa Alzheimer. Agbanyeghị, egosipụtabeghị mmetụta ndị a n'ime mmadụ. Nnwale ụlọ ọgwụ nke nkeji nke abụọ na-enyocha ugbu a ma benfotiamine nwere ike kwụsịlata nhụta n'ime ndị ọrịa nwere nhụsianya dị nro.
3. Imeri ịṅụbiga mmanya ókè
A na-ejikọta ịṅụ mmanya na-egbu oge na ụkọ nri dị mkpa na vitamin. A na-eji ụkọ thiamine metụtara mmanya na-egbu egbu bụ ọrịa akwara ozi n'ihi mfu nke ihe ọcha etiti na mpụta na-aga n'ihu. Ọ bụ ezie na nnọchi nke thiamine dị mkpa maka ndị ọrịa nwere mmebi sistemu ụjọ nke mmanya na-akpata, benfotiamine egosighi na ọ dị irè n'ịgafe sistemu ụjọ nke etiti site na mpụta.
4. Benfotiamine maka ise siga
Ịṅụ sịga na-eduga n'ịrụ ọrụ endothelial, ihe omume mbụ na ọrịa obi. Nke a na-akawanye njọ site na nrụgide oxidative na mbufụt. N'ime nyocha izizi banyere oke, a hụrụ benfotiamine iji gbochie arụrụ ọrụ vaskụla nke nicotine kpatara. Nnwale emere na ndị ọrụ afọ ofufo ahụike egosila na ọgwụgwọ obere oge na benfotiamine nwere ike weghachi ọrụ macrovascular na ndị na-ese anwụrụ ike.
5. Nchekwa akụrụ
Data sitere na ọmụmụ na oke na-egosi na benfotiamine na-enye ọrụ nchebe na akpụkpọ ahụ peritoneal na akụrụ fọdụrụ na peritoneal dialysis na uremia. Dị ka otu nnyocha e bipụtara na Journal of the American Society of Nephrology si kwuo, mgbakwunye nke benfotiamine n'ime nri na-eduga n'ịbawanye ọrụ transketolase na mbelata nkwupụta nke ngwaahịa njedebe glycation dị elu na ndị na-anabata ha.
Ọmụmụ nke Ustuner et al. E bipụtara na Tissue and Cell chọpụtara na mgbakwunye benfotiamine nwere ike inye aka n'ịbelata nephrotoxicity nke nje na-akpata site na mmụba nke nrụgide oxidative na mbufụt nke sel tubular renal.
6. Antitumor nwere ike
Nnyocha ọmụmụ in vitro na-egosi na benfotiamine nwere ike kwụsị ọrịa leukemia site na usoro a na-akpọ ọnwụ paraptosis cell. Paraptosis bụ ụdị ọnwụ sel emebere nke gụnyere nhazi cytoplasmic vacuole. Nnyocha omenala cell nke ndị nyocha nke Mahadum Kanazawa dị na Japan chọpụtara na benfotiamine bụ ihe na-ekwe nkwa maka nnukwu ndị ọrịa leukemia myeloid na-erughị eru maka ọgwụgwọ chemotherapy. Ha chọpụtakwara na benfotiamine gosipụtara ọrụ synergistic na cytarabine, onye na-ahụ maka chemotherapeutic, iji kpochapụ mkpụrụ ndụ leukemia myeloid.
7. Njirimara antioxidant
Benfotiamine bụkwa antioxidant dị ike nwere ihe mgbochi mkpali nke a na-emepụta site na mgbochi nke prostaglandin na leukotriene njikọ.
Usoro onunu ogwu: Ego ole Benfotiamine kwesịrị ị were?
Gị na onye na-ahụ maka ahụike na-ekwurịta okwu mgbe niile tupu ị were mgbakwunye iji hụ na mgbakwunye na usoro ọgwụgwọ dabara adaba maka mkpa gị.
Enwebeghị ndụmọdụ usoro onunu ogwu dị mma ma ọ bụ dị irè maka benfotiamine dị ka ọgwụgwọ maka ọnọdụ ọ bụla.
Imirikiti ọmụmụ ihe na ndị nwere ọrịa shuga ejirila doses nke 300 mg ugboro abụọ n'ụbọchị. Ọnwụnwa ndị ọzọ ejirila doses dị elu dị ka 900 mg kwa ụbọchị na-enweghị nnukwu nsogbu.
Ọ bụrụ na ịchọrọ ịnwale mgbakwunye benfotiamine, gwa onye na-ahụ maka ahụike gị okwu. Ha nwere ike iduzi gị ma ọ dị gị mma ma nyere gị aka ikpebi usoro onunu ogwu kwesịrị ekwesị.
Oge nzipu: Eprel-04-2023
