Iyini i-Benfotiamine?

1. I-diabetesic neuropathy

Ukwelashwa kwe-Benfotiamine kubonakala kuyisu elingaba khona lokuvimbela i-nephropathy yesifo sikashukela, inkinga enzima yesifo sikashukela, ehambisana nobungozi obukhulu besifo senhliziyo nokufa. Ukugxila okuphezulu kweglucose kuholela ekuqongeleleni ama-triosephosphates; lokhu kuholela ekungasebenzini kahle kwamakhemikhali ezinto eziphilayo futhi ekugcineni kuthuthuke i-nephropathy yesifo sikashukela.

Ucwaningo lwangaphambi komtholampilo kumagundane lubonise ukuthi i-benfotiamine ivimbela ukuqoqwa kwe-triosephosphates kushukela futhi ngaleyo ndlela ivimbele ukukhula kwe-nephropathy.

2. Ukuthuthukiswa kwengqondo ku-Alzheimer's disease

Ucwaningo lwangaphambi kweklinikhi lubonise ukuthi i-benfotiamine inikeza imiphumela enenzuzo ekukhubazekeni kwengqondo esifo i-Alzheimer's. I-Benfotiamine ikhonjiswe ukuthi yehlisa ukufakwa kwe-amyloid kumamodeli ezilwane zesifo i-Alzheimer's. Nokho, le miphumela ayizange ifakazelwe kubantu. Uhlolo lwesigaba sesi-II somtholampilo okwamanje luhlola ukuthi ingabe i-benfotiamine ingakwazi yini ukumisa ukwehla kwengqondo ezigulini ezinokukhubazeka okuncane kwengqondo.

3. Ukunqoba umlutha wotshwala

Ukuphuza utshwala okungapheli kuhlotshaniswa nokuntuleka okukhulu kwezakhi ezibalulekile namavithamini. Ukushoda kwe-thiamine okuhlobene nokudakwa kubonakala ngama-syndromes emizwa ngenxa yokulahleka okuqhubekayo kwendaba emhlophe emaphakathi ne-peripheral. Nakuba ukushintshwa kwe-thiamine kubalulekile ezigulini ezinokulimala kwesistimu yezinzwa emaphakathi ebangelwa utshwala, i-benfotiamine ayizange ibonakale iphumelela ekudluleleni ohlelweni lwezinzwa olumaphakathi isuka emaphethelweni.

4. I-Benfotiamine yokubhema

Ukubhema kuholela ekungasebenzi kahle kwe-endothelial, isenzakalo sokuqala sesifo senhliziyo. Lokhu kubhebhethekiswa ukucindezeleka kwe-oxidative nokuvuvukala. Ocwaningweni lwangaphambi komtholampilo wamagundane, i-benfotiamine itholakale ivimbela ukungasebenzi kahle kwemithambo okubangelwa i-nicotine. Uhlolo olwenziwe kumavolontiya anempilo lubonise ukuthi ukwelashwa kwesikhashana nge-benfotiamine ngokwengxenye kungabuyisela ukusebenza kwe-macrovascular kubabhemi abanempilo.

5. Ukuvikelwa kwezinso

Idatha evela ocwaningweni kumagundane iphakamisa ukuthi i-benfotiamine inikeza isenzo sokuvikela kulwelwesi lwe-peritoneal kanye nezinso eziyinsalela ku-peritoneal dialysis kanye ne-uremia. Ngokocwaningo olushicilelwe ku-Journal of the American Society of Nephrology, ukungezwa kwe-benfotiamine ekudleni kuholela ekwandeni komsebenzi we-transketolase kanye nokuncipha kokubonakaliswa kwemikhiqizo yokugcina ye-glycation kanye ne-receptor yayo.

Ucwaningo olwenziwa ngu-Ustuner et al. eshicilelwe kwethi Tissue and Cell ithole ukuthi isithasiselo se-benfotiamine singase sibe usizo ekwehliseni i-nephrotoxicity ebangelwa ama-antibiotic ngokusebenzisa ukuthuthukiswa kokucindezeleka okwenziwe nge-oxidative nokuvuvukala kwamangqamuzana ezinso ze-tubular.

6. Amandla e-Antitumor

Ucwaningo lwe-in vitro luphakamisa ukuthi i-benfotiamine ingase imise i-leukemia ngomshini obizwa ngokuthi i-paraptosis cell death. I-Paraptosis uhlobo lokufa kweseli okuhleliwe okubandakanya ukwakheka kwe-vacuole ye-cytoplasmic. Ucwaningo lwe-cell culture olwenziwa abacwaningi base-Kanazawa University e-Japan luthole ukuthi i-benfotiamine iyi-ejenti ethembisayo yeziguli ze-acute myeloid leukemia ezingafanelekile ukuthola i-chemotherapy evamile. Baphinde babona ukuthi i-benfotiamine ibonise umsebenzi we-synergistic ne-cytarabine, i-chemotherapeutic agent, ukuqeda amangqamuzana e-myeloid leukemia.

7. Izakhiwo ze-Antioxidant

I-Benfotiamine futhi iyi-antioxidant enamandla enezindawo zokulwa nokuvuvukala ezikhiqizwa ngokuvimbela i-prostaglandin kanye ne-leukotriene synthesis.