Yintoni iBenfotiamine?

1. I-diabetes neuropathy

Unyango lwe-Benfotiamine lubonakala luyisicwangciso esinokuthi sithintele i-nephropathy yesifo sikashukela, ingxaki enzima yesifo sikashukela, ehambelana nomngcipheko omkhulu wesifo senhliziyo kunye nokufa. Ukugxilwa kweglucose ephezulu kukhokelela ekuqokeleleni kwe-triosephosphates; oku kukhokelela ekungasebenzini kakuhle kwe-biochemical kwaye ekugqibeleni ukuphuhliswa kwe-nephropathy yesifo seswekile.

Uphononongo lwangaphambili kwiigundane lubonise ukuba i-benfotiamine inqanda ukuqokelelwa kwe-triosephosphates kwisifo seswekile kwaye ngenxa yoko inqanda uphuhliso lwe-nephropathy.

2. Ukuphuculwa kwengqondo kwi-Alzheimer's disease

Uphononongo lwangaphambili lubonise ukuba i-benfotiamine inika iziphumo eziluncedo kuphazamiseko lwengqondo kwisifo sika-Alzheimer. I-Benfotiamine ibonakaliswe ukunciphisa ukuchithwa kwe-amyloid kwiimodeli zezilwanyana ze-Alzheimer's disease. Nangona kunjalo, ezi ziphumo azikangqinwa ebantwini. Ulingo lwesigaba sesi-II sonyango ngoku luvavanya ukuba ingaba i-benfotiamine inokukumisa ukwehla kwengqondo kwizigulane ezinokukhubazeka okungephi.

3. Ukoyisa ukuxhomekeka etywaleni

Ukusetyenziswa kotywala okungapheliyo kuhambelana nokunqongophala okukhulu kwezondlo ezibalulekileyo kunye namavithamini. Ukunqongophala kwe-thiamine okunxulumene notywala kubonakaliswa zii-syndromes ze-neurological ngenxa yokulahleka okuqhubelekayo kombindi kunye ne-peripheral white matter. Nangona ukutshintshwa kwe-thiamine kubalulekile kwizigulana ezinomonakalo wenkqubo yemithambo-luvo esembindini ebangelwa butywala, i-benfotiamine ayikhange ibonakalise ukusebenza kakuhle ekuweleni kwinkqubo yemithambo-luvo ephakathi ukusuka kumda.

4. I-Benfotiamine yokutshaya

Ukutshaya kubangela ukungasebenzi kakuhle kwe-endothelial, isiganeko sokuqala kwisifo senhliziyo. Oku kwandiswa ngoxinzelelo lwe-oxidative kunye nokuvuvukala. Kuphononongo lwe-preclinical kwiigundane, i-benfotiamine yafunyanwa ukukhusela ukungasebenzi kakuhle kwe-nicotine-induced vascular dysfunction. Ulingo olwenziwa kumavolontiya asempilweni lubonise ukuba unyango lwexesha elifutshane nge-benfotiamine lunokubuyisela ngokuyinxenye ukusebenza kwe-macrovascular kwintshayi esempilweni.

5. Ukhuseleko lwezintso

Idatha evela kwizifundo kwi-rat icebisa ukuba i-benfotiamine inika isenzo sokukhusela kwi-peritoneal membrane kunye nentsalela yezintso kwi-peritoneal dialysis kunye ne-uremia. Ngokophononongo olupapashwe kwiJenali ye-American Society of Nephrology, ukongezwa kwe-benfotiamine ekutyeni kukhokelela ekwandeni komsebenzi we-transketolase kunye nokuncipha kokubonakaliswa kweemveliso zokugqibela ze-glycation kunye ne-receptor yazo.

Uphononongo olwenziwe ngu-Ustuner et al. epapashwe kwiTissue kunye neCell yafumanisa ukuba i-benfotiamine yongezelela inokuba luncedo ekunciphiseni i-nephrotoxicity eyenziwe ngamayeza okubulala iintsholongwane ngokusebenzisa ukuphuculwa koxinzelelo lwe-oxidative kunye nokudumba kweeseli ze-renal tubular.

6. Amandla e-Antitumor

Izifundo ze-in vitro zibonisa ukuba i-benfotiamine inokumisa i-leukemia ngendlela ebizwa ngokuba yi-paraptosis cell death. I-Paraptosis luhlobo lokufa kweseli okucwangcisiweyo okubandakanya ukwakheka kwe-vacuole ye-cytoplasmic. Uphononongo lwenkcubeko yeseli olwenziwa ngabaphandi beYunivesithi yaseKanazawa eJapan lufumanise ukuba i-benfotiamine yiarhente ethembisayo kwizigulana ze-acute myeloid leukemia ezingafanelanga ukufumana unyango oluqhelekileyo lwechemotherapy. Baye baqaphela ukuba i-benfotiamine ibonise umsebenzi we-synergistic kunye ne-cytarabine, i-agent ye-chemotherapeutic, ukuphelisa iiseli ze-myeloid leukemia.

7. Iimpawu ze-Antioxidant

I-Benfotiamine ikwayi-antioxidant enamandla eneempawu ezichasayo eziveliswa ngokuthintelwa kwe-prostaglandin kunye ne-leukotriene synthesis.