Ihuriro rikomeye - Spermidine + NMN (Nicotinamide Mononucleotide)

Spermidine & nicotinamide mononucleotide (NMN) ni iki?

Spermidine ni polyamine, bivuze ko ifite amatsinda abiri cyangwa menshi yibanze ya amino. Nibisanzwe bibaho kandi bigaragara cyane muri ribosomes hamwe nuduce twizima. Ifite uruhare runini mumikorere ya selile no kubaho.

Spermidine yavumbuwe bwa mbere mu 1678 n'umuhanga mu Buholandi Anton Van Leeuwenhoek mu cyitegererezo cy'amasohoro y'abantu. Nyuma gato, spermidine yavumbuwe mu ntanga ngabo. Mu mubiri, spermidine ikorwa kuva prursor putrescine. Nibibanziriza indi polyamine yitwa spermine, nayo ifite akamaro mumikorere ya selile.

Spermidine na putrescine bizwiho gutera autophagy. Sisitemu isenya imyanda imbere muri selile kandi igasubiramo ibice bigize selile. Nuburyo bwingenzi bwo kugenzura ubuziranenge bwa mitochondriya, imbaraga za selile zacu. Autophagy yemerera mitochondriya yangiritse cyangwa ifite inenge kumeneka no kujugunywa. Kurandura mitochondriya bigenzurwa cyane kuruta uko byari bisanzwe.

Polyamine irashobora guhuza ubwoko bwinshi bwa molekile bigatuma iba ingirakamaro cyane. Bashyigikira inzira, harimo gukura kwingirabuzimafatizo, ADN itajegajega, ikwirakwizwa rya selile, na apoptose [2]. Bigaragara kandi ko polyamine ikora muburyo busa nibintu bikura mugihe cyo kugabana. Niyo mpamvu putrescine na spermidine ari ngombwa kugirango imikurire yimikorere myiza.

NMN ni ubwoko bwa molekile yitwa nucleotide. Nucleotide igira uruhare runini mumubiri wawe, harimo nkibice byubaka ADN.

Muri selile zawe, NMN ihindurwamo indi molekile izwi nka nicotinamide adenine dinucleotide (NAD). Umubiri wawe ukeneye NAD kubikorwa bitandukanye bigira uruhare muri metabolism no kubyara ingufu.

Urashobora gutekereza kuri NMN nkibikoresho fatizo na NAD nka verisiyo inoze umubiri wawe ushobora gukoresha.

Ingano ya NAD umubiri wawe ushobora gukora biterwa numubare wa NMN uboneka mumubiri wawe.

Nibihe biribwa biri muri spermidine & nicotinamide mononucleotide (NMN)?

Hariho amasoko menshi yimirire ya spermidine harimo imbuto zimbuto, ibicuruzwa bya soya, ibinyamisogwe, ibigori, ingano zose, inkeri, amashaza, urusenda rwatsi, broccoli, amacunga, icyayi kibisi, umuceri wumuceri, na peporo yicyatsi kibisi.

Irashobora kandi kuboneka mubihumyo bya shitake, ingano ya amaranth, mikorobe y'ingano, kawuseri, broccoli, na foromaje zitandukanye zikuze, na durian.

Birakwiye ko tumenya ko indyo yuzuye ya Mediterane irimo ibiryo bikungahaye kuri spermidine. Ibi birashobora nibura gusobanura ibyabaye kuri "zone yubururu" n'impamvu abantu baho bakunze kubaho igihe kirekire kuruta ahandi.

NMN ubwayo ni ibintu bikubiye mu mubiri w'umuntu, biboneka mu mashereka n'ibiribwa, nka edampoa, broccoli, inkeri, imyumbati, avoka, inyanya, n'ibindi, ariko ibirimo ni bike cyane (0,25-1,88 mg kuri 100 garama). Inyama zinka na shrimp nazo zirimo bike cyane (0.06-0.42 mg kuri 100 g) ya NMN.

Inyungu za spermidine & nicotinamide mononucleotide (NMN):

Spermidine ihuza na NMN, yongerera neza inyungu zabo
Spermidine na autophagy:Spermidine nayo igira uruhare runini mubikorwa byinshi byingenzi byibinyabuzima ， Ubushobozi bwa spermidine yo gukurura autofagy butekereza ko aribwo buryo nyamukuru bugaragaza ko butinda gusaza no gushyigikira kuramba.

Spermidine anti-inflammatory:Biremewe hose ko nubwo gutwika bigira uruhare runini mugukiza ibikomere no kurwanya indwara ziterwa na virusi, umuriro uhoraho ujyanye no gusaza, bakunze kwita gutwika, ni bibi. Indurwe idakira irinda ingirabuzimafatizo nziza, itera ingirabuzimafatizo zidakora neza, ndetse zishobora kwihutisha umuvuduko ingirabuzimafatizo nzima ziba senescent. Spermidine isa nkigabanya iyi ndurwe idakira kandi irashobora kugabanya umuvuduko umwe ingirabuzimafatizo zisaza.

Spermidine kandi irashobora gutinza gusaza:Kuramba, ubuyobozi bwa spermidine bwerekanye ko bwongera igihe cyo kubaho mubushakashatsi butandukanye bw’inyamaswa kandi bukarinda fibrosis yumwijima na kanseri ya hepatocellular. Ibi kandi bigaragara ko bimeze kumirire ikungahaye kuri polyamine. Hariho ibimenyetso bimwe byerekana ko bitezimbere kunanira imihangayiko kandi ko kugabanuka kwimyaka biterwa na spermidine bifasha gutangira indwara ziterwa nimyaka.

Spermidine irashobora kugabanya kugabanuka kwubwenge:Ubushakashatsi bwasohotse mu 2021 mu kinyamakuru Cell Reports butanga inkuru irambuye ya spermidine yimirire itezimbere ubumenyi bwimikorere nimikorere ya mito-iyambere mumisazi nimbeba, hamwe nibishobora kuba byamakuru byabantu kugirango babirangize. Nubwo ubu bushakashatsi bwari bushimishije, bwari bufite aho bugarukira, kandi hakenewe andi makuru yinyongera-asubiza mbere yuko hafatwa umwanzuro ushimishije kubyerekeye inyungu zubwenge bwabantu.

Itezimbere imikorere yubwonko:NMN yerekanwe kunoza ubumenyi bwimbeba hamwe na Alzheimer no kugabanya ibyapa byubwonko na neurodegenration mumbeba za Alzheimer. Mugihe Alzheimer ari indwara yanyuma, abantu benshi bakuze nabo bafite ikibazo cyo kutamenya - kudashobora kwiga, kwibuka, no gutekereza neza. Izi mbogamizi zijyanye n'imyaka zabujijwe na NMN mu mbeba. Ubumuga bwo kutamenya burigihe bujyana no kwiheba, nabwo byagaragaye ko bwagabanijwe na NMN mu mbeba.

Kubera ko imiyoboro y'amaraso yacu idakora neza uko dusaza, umuvuduko w'amaraso mu bwonko bwacu uba wangiritse, biganisha ku bumuga bwo kutamenya. NMN yerekanwe kongera umuvuduko wamaraso mubwonko no kunoza imikorere yubwenge mumbeba. Iyo imiyoboro y'amaraso mu bwonko bwacu ifunze, dushobora kugira ubwonko, aho ubwonko bwacu bwangirika. NMN ntiyerekanye gusa kudindiza indwara yubwonko gusa, ahubwo yanarinze kwangirika kwubwonko, no kunoza imitekerereze nubuzima bwa mito-iyambere nyuma yubwonko bwimbeba.

Kunoza imikorere yimitsi:Twishingikirije kumitsi yacu ya skeletale kugirango igende, ituze, n'imbaraga. Mugihe tugenda dusaza, imitsi yacu itakaza ubushobozi bwo kuvuka no gukura, biganisha kumyaka ijyanye no kugabanuka kwingufu zimitsi nubunini bwitwa sarcopenia. Hamwe n'intege nke z'imitsi, natwe turaruha kandi dufite kwihangana kumubiri. NMN isa naho ihindura ibi bintu, kuko umwe mubayitwaye yerekanwe kongera imbaraga no kwihangana kumubiri.
Itezimbere Umutima Muzima ： NMN yerekanwe kurinda indwara z'umutima mu mbeba. Imitsi yumutima yacu ni iyagaciro, kuko itazwiho kuvuka. Ahubwo, ingirangingo zangiritse zigaragara mu nkovu (fibrosis), biganisha ku gukora nabi k'umutima. NMN igarura imikorere yimitima yimbeba mugabanya inkovu. Gukubita buri gihe kandi burigihe, umutima usaba imbaraga nyinshi. Kubwibyo, ikenera mitochondriya nzima. NMN itezimbere metabolism yumutima kandi ikarinda kunanirwa k'umutima, igice kimwe cyo kuvugurura mitochondriya.

Irinda umubyibuho ukabije na Diyabete:Umubyibuho ukabije ufitanye isano n’ibura ryinshi rya metabolike, harimo no kurwanya insuline - igihe ingirabuzimafatizo zidashobora gukoresha glucose bitewe n’ibimenyetso bya insuline byangiritse - bishobora gutera diyabete. Mitochondria niho selile yanyuma ya selile ibiryo turya bihindurwamo ingufu, bikaba bifite akamaro kanini muri metabolism n'indwara zifitanye isano. NMN yerekanwe kwikuba kabiri mitochondriya mu mbeba z’imbeba zifite umubyibuho ukabije, zishobora kurinda umubyibuho ukabije. Gukangura ibinure hamwe na NMN birashobora kandi gufasha abantu babyibushye gutakaza amavuta.
NMN ifasha mu gusaza: Urwego rwa NMN na NAD rusanzwe rugabanuka uko imyaka igenda ishira, abashakashatsi benshi rero bavuze ko gufata inyongera za NMN bishobora gufasha mubibazo byubuzima.

Ubushakashatsi bwakorewe ku bagabo 10 b'Abayapani bwerekanye ko gufata NMN (100, 250, cyangwa 500 mg) byongera urugero rwa NMN byongera umusaruro mu maraso, harimo na NAD. Kurwanya insuline birashobora gukura hamwe n'imyaka Yizewe kandi ni imwe mu mpamvu zituma diyabete ikunze kugaragara mu bakuze abantu bakuru. Gufata inyongera ya NMN byagaragaye kandi ko bigabanya gusinzira no kunoza imitsi kubantu bakuze, bishobora kuzamura ubuzima bwumubiri nubwenge hamwe nimyaka.

Umubare

Urebye amakuru make aboneka mugutwara inyongera ya NMN, biragoye kumenya igipimo cyiza. Ubushakashatsi bwerekanye inyungu zubuzima hamwe na dosiye ziri munsi ya 250 mg ya NMN kumunsi, hamwe na spermidine ya 10 - 20 mg.

Niba ubishaka, nyamuneka hamagara XI'AN AOGU BIOTECH!