Menene Spermidine & nicotinamide mononucleotide (NMN)?
Spermidine polyamine ne, ma'ana yana da rukunin amino guda biyu ko fiye. Yana faruwa ne a zahiri kuma ana haɗuwa da shi sosai a cikin ribosomes da kyallen takarda masu rai. Yana taka muhimmiyar rawa a aikin sel da rayuwa.
An fara gano Spermidine a shekara ta 1678 daga wani masanin kimiya dan kasar Holland Anton Van Leeuwenhoek a cikin samfurin maniyyin dan adam. Ba da daɗewa ba, an gano maniyyi a cikin maniyyi na mutum. A cikin jiki, an halicci spermidine daga precursor putrescine. Ita ce farkon wani polyamine da ake kira maniyyi, wanda kuma yana da mahimmanci ga aikin salula.
Spermidine da putrescine an san su don tayar da autophagy. Tsarin da ke wargaza sharar gida a cikin sel da sake sarrafa abubuwan salula. Yana da mahimmancin tsarin kula da inganci ga mitochondria, ma'ajin ƙarfin ƙwayoyin mu. Autophagy yana ba da damar lalata mitochondria mai lahani da lalacewa da zubar da shi. Zubar da mitochondria yana da ƙarfi sosai fiye da yadda aka yi imani da shi.
Polyamines na iya ɗaure ga nau'ikan kwayoyin halitta daban-daban waɗanda ke sa su da amfani sosai. Suna tallafawa matakai, gami da haɓakar tantanin halitta, kwanciyar hankali na DNA, haɓakar tantanin halitta, da apoptosis [2]. Har ila yau, ya bayyana cewa polyamines suna aiki a irin wannan hanya zuwa abubuwan girma yayin rarrabawar tantanin halitta. Wannan shine dalilin da ya sa putrescine da spermidine suna da mahimmanci ga ci gaban nama da aiki.
NMN wani nau'in kwayoyin halitta ne da ake kira nucleotide. Nucleotides suna taka rawa da yawa a cikin jikin ku, gami da a matsayin tubalan ginin DNA.
A cikin sel ɗin ku, NMN yana canzawa zuwa wani nau'in kwayar halitta da aka sani da nicotinamide adenine dinucleotide (NAD). Jikin ku yana buƙatar NAD don ayyuka daban-daban waɗanda ke cikin metabolism da samar da makamashi.
Kuna iya tunanin NMN azaman albarkatun ƙasa da NAD azaman ingantaccen sigar da jikin ku zai iya amfani da shi.
Adadin NAD da jikin ku zai iya yi ya dogara da adadin NMN da ke cikin jikin ku.
Wadanne abinci ne ke cikin spermidine & nicotinamide mononucleotide (NMN)?
Akwai tushen abinci da yawa na maniyyi ciki har da innabi, kayan waken soya, legumes, masara, dukan hatsi, chickpeas, Peas, barkono kore, broccoli, lemu, koren shayi, shinkafa shinkafa, da barkono barkono.
Hakanan ana iya samun shi a cikin namomin kaza na shitake, hatsin amaranth, ƙwayar alkama, farin kabeji, broccoli, da nau'ikan cukuwan balagagge, da durian.
Ya kamata a lura da cewa yawancin abincin da ke cikin Rumunan ya ƙunshi abinci mai arziki na spermidine. Wannan na iya aƙalla bayyana abubuwan mamaki na "yankunan shuɗi" da kuma dalilin da yasa mutane a can sukan rayu tsawon lokaci fiye da sauran wurare.
Ita kanta NMN wani sinadari ne da ke cikin jikin mutum, wanda yake cikin nono da abinci, irin su edampoa, broccoli, cucumber, kabeji, avocado, tumatur, da dai sauransu, amma abin da ke cikin shi kadan ne (0.25-1.88 mg a kowace 100). grams). Danyen naman sa da jatan lande kuma sun ƙunshi ƙananan adadi (0.06-0.42 mg a kowace g 100) na NMN.
Amfanin spermidine & nicotinamide mononucleotide (NMN):
Spermidine yana ɗaure zuwa NMN, yana haɓaka fa'idodin su yadda ya kamata
Spermidine da autophagy:Spermidine kuma yana taka muhimmiyar rawa a cikin matakai masu mahimmanci na ilimin halitta, Ƙarfin spermidine don haifar da autophagy ana tunanin shine babban tsarin da ya bayyana don rage tsufa da tallafawa tsawon rai.
Spermidine anti-mai kumburi Properties:An yarda da shi sosai cewa yayin da kumburi ke taka rawa wajen warkar da raunuka da kuma tunkuɗe masu kamuwa da cuta, kumburin da ke da alaƙa da tsufa, wanda galibi ake kira kumburi, yana da illa. Kumburi na yau da kullun yana hana farfadowar nama mai lafiya, yana haifar da ƙwayoyin rigakafi su zama marasa aiki, har ma yana iya haɓaka saurin da ƙwayoyin lafiya suka zama hankalta. Spermidine yana bayyana yana rage wannan kumburi na yau da kullun kuma yana iya rage gudu hanya ɗaya da sel da kyallen takarda ke tsufa.
Spermidine kuma yana iya jinkirta tsufa:A kan tsayin daka, an nuna kulawar spermidine don ƙara yawan rayuwa a yawancin nazarin dabbobi kuma yana hana hanta fibrosis da ciwon daji na hepatocellular. Wannan kuma ya bayyana ya kasance yanayin cin abinci mai arziki a cikin polyamines. Har ila yau, akwai wasu shaidun da ke nuna cewa yana inganta juriya ga danniya da kuma cewa raguwar shekarun haihuwa na spermidine yana goyon bayan farawar cututtukan da suka shafi shekaru.
Spermidine na iya rage raguwar fahimi:Binciken da aka buga a cikin 2021 a cikin mujallar Cell Reports yana ba da cikakken bayani game da spermidine na abinci yana inganta fahimta da aikin mitochondrial a cikin kwari da mice, tare da wasu bayanan ɗan adam mai yiwuwa don kashe shi. Duk da yake wannan binciken ya kasance mai ban sha'awa, yana da wasu iyakoki, kuma ana buƙatar ƙarin bayanan amsa-kashi kafin a iya yanke shawara mai mahimmanci game da fa'idodin fahimtar ɗan adam.
Yana Inganta Aikin Kwakwalwa:An nuna NMN don inganta cognition a cikin rodents tare da Alzheimer's da kuma rage alamomin kwakwalwa da neurodegenration a cikin berayen Alzheimer. Yayin da cutar Alzheimer cuta ce ta ƙarshe, yawancin tsofaffi kuma suna fama da nakasuwar fahimta - rashin iya koyo, tunawa, da tunani da kyau. NMN ta hana waɗannan nakasar fahimi masu alaƙa da shekaru a cikin beraye. A wasu lokuta ana haɗuwa da rashin fahimta tare da bacin rai, wanda kuma NMN ya nuna yana ragewa a cikin berayen.
Domin magudanar jininmu suna zama marasa aiki yayin da muka tsufa, jini zuwa kwakwalwarmu yana lalacewa, yana haifar da rashin fahimta. An nuna NMN don ƙara yawan jini zuwa kwakwalwa da inganta aikin tunani a cikin mice. Lokacin da jijiyoyin jini a cikin kwakwalwarmu suka toshe, za mu iya samun bugun jini, ta yadda naman kwakwalwarmu ke lalacewa. An nuna NMN ba kawai jinkirin bugun jini ba, amma har ma don hana lalacewar bugun jini, da inganta fahimta da lafiyar mitochondrial bayan bugun jini a cikin rodents.
Yana Inganta Aikin tsoka:Muna dogara ga tsokoki na kwarangwal don motsi, kwanciyar hankali, da ƙarfi. Yayin da muke tsufa, tsokoki sun rasa ikon su na farfadowa da girma, wanda ke haifar da raguwar shekarun da suka shafi ƙarfin tsoka da girman da ake kira sarcopenia. Tare da raunin tsoka, muna kuma ƙara gajiya kuma muna da ƙarancin juriya na jiki. NMN yana da alama yana juyar da waɗannan sharuɗɗan, kamar yadda aka nuna ɗaya daga cikin masu jigilar ta don ƙara ƙarfi da juriya ta jiki a cikin beraye.
Yana Haɓaka Lafiyayyan Zuciya: An nuna NMN don kariya daga raunin zuciya a cikin beraye. Naman zuciyar mu yana da daraja, kamar yadda ba a san shi don sake farfadowa ba. Madadin haka, nama mai lalacewa yana bayyana a cikin tabo (fibrosis), yana haifar da rashin aiki na zuciya. NMN yana dawo da aikin zuciyar linzamin kwamfuta ta hanyar rage tabo. Duka akai-akai kuma har abada, zuciya tana buƙatar ƙarfi mai yawa. Don wannan, yana buƙatar lafiya mitochondria. NMN yana inganta metabolism na zuciya kuma yana kare kariya daga gazawar zuciya, a wani bangare ta hanyar farfado da mitochondria.
Yana Kariya Daga Kiba da Ciwon Suga:Kiba yana da alaƙa da ƙarancin ƙarancin rayuwa, gami da juriya na insulin - lokacin da ƙwayoyin sel ba za su iya amfani da glucose ba saboda ƙarancin siginar insulin - wanda zai iya haifar da ciwon sukari. Mitochondria shine makoma ta wayar salula ta ƙarshe don abincin da muke ci don canza shi zuwa makamashi, yana mai da su mahimman mahimmancin metabolism da cututtukan da ke da alaƙa. An nuna NMN ya ninka adadin mitochondria a hantar berayen masu kiba, wanda zai iya kare kai daga kiba. Ƙarfafa rugujewar kitse tare da NMN na iya taimakawa masu kiba su rasa mai.
Taimakon NMN tare da tsufa: Matakan NMN da NAD a dabi'a suna raguwa tare da shekaru, don haka yawancin masu bincike sun ba da shawarar cewa shan kariyar NMN na iya taimakawa tare da matsalolin lafiya da suka shafi shekaru.
Wani bincike a cikin maza na Japan 10 ya gano cewa shan NMN (100, 250, ko 500 MG) ya karu da matakan NMN da ke cikin jini, ciki har da NAD.Insulin juriya zai iya tasowa tare da shekaruTrusted Source kuma yana daya daga cikin dalilan ciwon sukari ya fi kowa a cikin tsofaffi. manya. Hakanan an nuna shan abubuwan NMN don rage bacci da inganta jin daɗin tsoka a cikin tsofaffi, wanda zai iya inganta lafiyar jiki da ta hankali tare da shekaru.
Sashi
Ganin ƙayyadaddun bayanai da ake samu akan shan kari na NMN, yana da wahala a tantance madaidaicin kashi. Nazarin sun sami fa'idodin kiwon lafiya tare da allurai kamar 250 MG na NMN kowace rana, da adadin Spermidine na 10 - 20 MG.
Idan kuna sha'awar, da fatan za a tuntuɓi XI'AN AOGU BIOTECH !
Lokacin aikawa: Dec-29-2022
